全文获取类型
收费全文 | 1077篇 |
免费 | 75篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 47篇 |
妇产科学 | 17篇 |
基础医学 | 125篇 |
口腔科学 | 152篇 |
临床医学 | 76篇 |
内科学 | 246篇 |
皮肤病学 | 18篇 |
神经病学 | 75篇 |
特种医学 | 102篇 |
外科学 | 137篇 |
综合类 | 21篇 |
预防医学 | 60篇 |
眼科学 | 5篇 |
药学 | 26篇 |
中国医学 | 2篇 |
肿瘤学 | 42篇 |
出版年
2018年 | 10篇 |
2017年 | 11篇 |
2016年 | 11篇 |
2015年 | 16篇 |
2014年 | 21篇 |
2013年 | 18篇 |
2012年 | 28篇 |
2011年 | 41篇 |
2010年 | 11篇 |
2009年 | 11篇 |
2008年 | 39篇 |
2007年 | 47篇 |
2006年 | 33篇 |
2005年 | 36篇 |
2004年 | 33篇 |
2003年 | 36篇 |
2002年 | 30篇 |
2001年 | 35篇 |
2000年 | 35篇 |
1999年 | 29篇 |
1998年 | 14篇 |
1997年 | 16篇 |
1996年 | 15篇 |
1995年 | 13篇 |
1994年 | 13篇 |
1993年 | 15篇 |
1992年 | 35篇 |
1991年 | 37篇 |
1990年 | 24篇 |
1989年 | 31篇 |
1988年 | 30篇 |
1987年 | 38篇 |
1986年 | 36篇 |
1985年 | 45篇 |
1984年 | 17篇 |
1983年 | 16篇 |
1982年 | 17篇 |
1981年 | 14篇 |
1980年 | 15篇 |
1979年 | 25篇 |
1978年 | 14篇 |
1977年 | 12篇 |
1974年 | 18篇 |
1973年 | 9篇 |
1972年 | 11篇 |
1971年 | 7篇 |
1970年 | 15篇 |
1969年 | 7篇 |
1968年 | 8篇 |
1967年 | 9篇 |
排序方式: 共有1152条查询结果,搜索用时 15 毫秒
1.
D A Pegues C M Beck-Sague S W Woollen B Greenspan S M Burns L A Bland M J Arduino M S Favero R C Mackow W R Jarvis 《Kidney international》1992,42(5):1232-1237
From July 18 through November 27, 1989, 12 anaphylactoid reactions (ARs) occurred in 10 patients at a hemodialysis center in Virginia. One patient required hospitalization; no patients died. ARs occurred within minutes of initiating dialysis and were characterized by peripheral numbness and tingling, laryngeal edema or angioedema, facial or generalized sensation of warmth, and/or nausea or vomiting. All 12 ARs occurred with dialyzers that had been reprocessed with an automated reprocessing system. A cohort study, including all patients undergoing dialysis sessions on the six days when an AR occurred, showed that the patients who experienced ARs were significantly more likely than patients who did not to be treated with angiotensin-converting enzyme (ACE) inhibitors (7/10 vs. 3/33; relative risk = 7.9; 95% confidence interval = 2.5 to 25.2) and to have been exposed to reused dialyzers rather than to new dialyzers (12/70 sessions vs. 0/31; P = 0.016). In those sessions using a reused dialyzer, the mean number of dialyzer uses in case-sessions was significantly higher than for noncase-sessions (10.3 vs. 6.2; P = 0.016). After reuse of dialyzers was discontinued at the center, no further ARs occurred, despite the continued administration of ACE inhibitors. This is the first report of an outbreak of ARs associated exclusively with reused dialyzers. We hypothesize that interactions between a dialyzer that has been repeatedly reprocessed and reused, blood, and additional factors, such as ACE inhibitors, increased the risk of developing ARs. 相似文献
2.
3.
The Ca antigen has been reported to be present on the surface of malignant but not, with few exceptions, non-malignant cells. We investigated the potential usefulness of the monoclonal Ca 1 antibody in differentiating oral squamous cell carcinoma from non-malignant or premalignant oral neoplasms. Paraffin-embedded sections from 33 biopsy specimens of 12 hyperplastic and 21 neoplastic oral lesions were examined by immunohistochemical staining. Seven of the 33 specimens showed positive staining for Ca antigen. Fifteen of 21 specimens of oral squamous cell carcinoma were negative for Ca antigen, and one case of focal keratosis was positive. The results indicate that the use of the Ca 1 antibody to distinguish oral squamous cell carcinoma from non-malignant or premalignant oral lesions is highly unreliable. 相似文献
4.
5.
D A Present S F Bonar A Greenspan K Paonessa 《Clinical orthopaedics and related research》1988,(237):164-169
A case of clear-cell chondrosarcoma occurred in the proximal femur of a 32-year-old man. The tumor was complicated by a focus of myositis ossificans resulting from a previous intralesional biopsy. Histologic findings included an unusual marrow infiltration by the tumor. The patient was treated with wide resection and has no evidence of local recurrence or distant spread of disease 18 months later. 相似文献
6.
7.
8.
L A MacPhail D Greenspan J S Greenspan 《Oral surgery, oral medicine, and oral pathology》1992,73(3):283-288
Recurrent aphthous ulcers in patients with HIV infection can cause significant morbidity, which makes successful diagnosis and treatment imperative. We have found that the diagnostic paradigm for recurrent aphthous ulcers in HIV-seronegative patients, which is based on the ulcers' clinical appearance, location, absence of other ulcer-causing pathogens or pathogenic processes, and response to therapy, may be successfully applied to recurrent aphthous ulcers in HIV-infected patients. However, one must be alert for ulcers with uncommon causes as well as ulcers with common causes that have atypical clinical appearances that may mimic recurrent aphthous ulcers. The topical glucocorticoids, which are used to treat recurrent aphthous ulcers in HIV-seronegative patients, proved very effective in HIV-infected patients for treatment of herpetiform and minor ulcers and most major ulcers and were without notable side effects. A few severe cases of major recurrent aphthous ulcers required treatment with systemic prednisone, and some side effects were encountered. 相似文献
9.
G P Kent J R Greenspan J L Herndon L M Mofenson J A Harris T R Eng H A Waskin 《American journal of public health》1988,78(2):139-143
In the period November 1, 1985 to January 31, 1986, 703 cases of giardiasis were reported in Pittsfield, Massachusetts (population 50,265). The community obtained its water from two main reservoirs (A and B) and an auxiliary reservoir (C). Potable water was chlorinated but not filtered. The incidence of illness peaked approximately two weeks after the city began obtaining a major portion of its water from reservoir C, which had not been used for three years. The attack rate of giardiasis for residents of areas supplied by reservoir C was 14.3/1000, compared with 7.0/1000 in areas that received no water from reservoir C. A case-control study showed that persons with giardiasis were more likely to be older and to have drunk more municipal water than household controls. A community telephone survey indicated that over 3,800 people could have had diarrhea that might have been caused by Giardia, and 95 per cent of households were either using alternate sources of drinking water or boiling municipal water. Environmental studies identified Giardia cysts in the water of reservoir C. Cysts were also detected in the two other reservoirs supplying the city, but at lower concentrations. This investigation highlights the risk of giardiasis associated with unfiltered surface water systems. 相似文献
10.
Gor DO Ding X Li Q Schreiber JR Dubinsky M Greenspan NS 《Infection and immunity》2002,70(10):5589-5595
Immunization of mice with pneumococcal surface adhesin A (PsaA) emulsified in complete Freund's adjuvant (CFA) provides protection against systemic infection with Streptococcus pneumoniae. Because the use of CFA is not acceptable in humans, we sought to develop alternative means of enhancing the immunogenicity of protein antigens of potential use in pneumococcal vaccines. We designed a series of genetic constructs in which coding sequences for PsaA were linked to sequences encoding either murine interleukin-2 (mIL-2), mIL-4, or two copies of an immunostimulatory nonapeptide derived from mIL-1beta. The PsaA-cytokine constructs were cloned and expressed in Escherichia coli. Mice immunized twice with PsaA-IL-2, or PsaA-IL-4 responded with PsaA-specific antibody production comparable in magnitude to that of mice primed with PsaA in CFA and boosted with PsaA in incomplete Freund's adjuvant (PsaA-Adj). Antibodies elicited by PsaA-Adj were predominantly of the immunoglobulin G1 (IgG1) subclass, while PsaA-IL-2 and PsaA-IL-4 elicited substantial amounts of IgG2a in addition to IgG1. Mice immunized with PsaA-Adj or PsaA-IL-4 were partially protected against intraperitoneal challenge with virulent S. pneumoniae (30% overall survival beyond 15 days postchallenge). Mice immunized with PsaA and no adjuvant or PsaA-IL-2 exhibited 0 or 5% survival rates, respectively, following challenge. In contrast, mice immunized twice with capsular polysaccharide were 100% protected. The modest levels of protection seen in mice immunized with PsaA and its more immunogenic derivatives may be explained in part by the relative inaccessibility of antibody to PsaA on the surface of encapsulated S. pneumoniae. 相似文献