全文获取类型
收费全文 | 92525篇 |
免费 | 8268篇 |
国内免费 | 5308篇 |
专业分类
耳鼻咽喉 | 1164篇 |
儿科学 | 1216篇 |
妇产科学 | 856篇 |
基础医学 | 10602篇 |
口腔科学 | 1674篇 |
临床医学 | 10343篇 |
内科学 | 12644篇 |
皮肤病学 | 1599篇 |
神经病学 | 4150篇 |
特种医学 | 4275篇 |
外国民族医学 | 21篇 |
外科学 | 9210篇 |
综合类 | 15644篇 |
现状与发展 | 32篇 |
一般理论 | 7篇 |
预防医学 | 7245篇 |
眼科学 | 2529篇 |
药学 | 10303篇 |
90篇 | |
中国医学 | 5212篇 |
肿瘤学 | 7285篇 |
出版年
2024年 | 257篇 |
2023年 | 1157篇 |
2022年 | 2893篇 |
2021年 | 3972篇 |
2020年 | 2969篇 |
2019年 | 2495篇 |
2018年 | 2721篇 |
2017年 | 2708篇 |
2016年 | 2764篇 |
2015年 | 4211篇 |
2014年 | 5283篇 |
2013年 | 5367篇 |
2012年 | 7866篇 |
2011年 | 8347篇 |
2010年 | 5854篇 |
2009年 | 5123篇 |
2008年 | 6060篇 |
2007年 | 5783篇 |
2006年 | 5341篇 |
2005年 | 4635篇 |
2004年 | 3494篇 |
2003年 | 3365篇 |
2002年 | 2761篇 |
2001年 | 1955篇 |
2000年 | 1647篇 |
1999年 | 1323篇 |
1998年 | 806篇 |
1997年 | 723篇 |
1996年 | 615篇 |
1995年 | 553篇 |
1994年 | 531篇 |
1993年 | 356篇 |
1992年 | 378篇 |
1991年 | 348篇 |
1990年 | 292篇 |
1989年 | 266篇 |
1988年 | 174篇 |
1987年 | 194篇 |
1986年 | 145篇 |
1985年 | 97篇 |
1984年 | 56篇 |
1983年 | 39篇 |
1982年 | 39篇 |
1981年 | 27篇 |
1980年 | 28篇 |
1979年 | 16篇 |
1978年 | 6篇 |
1975年 | 7篇 |
1973年 | 11篇 |
1972年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
An-feng TAO Zheng-hao XU Cheng-hao WU Yi WANG Wei-wei HOU Shi-hong ZHANG Zhong CHEN 《浙江大学学报(医学版)》2015,44(3):315
目的观察比较不同脉冲波形的低频率电刺激对海马电点燃癫痫模型小鼠的作用差异。方法采用电点燃刺激法建立小鼠癫痫模型, 观察正弦波、单相方波、双相方波低频率电刺激对模型小鼠癫痫行为发作及后放电持续时间的影响, 并比较不同时间点给予正弦波低频率电刺激的抗癫痫作用。结果与对照组比较, 正弦波低频率电刺激30 s能降低小鼠海马电点燃癫痫发作等级(2.85 ± 0.27 vs 4.75 ±0.12, P < 0.05)、减少大发作概率(53.6% vs 96.5%, P < 0.01) 和缩短后放电持续时间[(16.22 ± 1.69) s vs (30.29 ± 1.12) s, P < 0.01], 而单相方波和双相方波低频率电刺激30 s没有明显的抗癫痫作用。常用的单相方波低频率电刺激15 min能降低小鼠海马电点燃发作等级(3.58 ± 0.16, P < 0.05)、减少大发作概率(66.7%, P < 0.01);但对海马后放电持续时间及大发作持续时间无影响(均 P>0.05)。此外, 电点燃刺激前预先给予或结束后3 s内给予正弦波低频率电刺激具有明显的抗癫痫作用( P < 0.05或 P < 0.01), 而电点燃刺激结束10 s给予正弦波低频率电刺激则无上述抗癫痫作用。 结论低频率电刺激抗癫痫作用受波形参数的影响, 其中正弦波低频率电刺激能有效抑制小鼠海马电点燃癫痫的发作。 相似文献
3.
4.
雄激素不敏感综合征(androgen insensitivity syndrome,AIS)又称为睾丸女性化综合征(testicular feminization syndrome,TFS),是一种X连锁遗传病,是男性假两性畸形中较常见的类型,可分为完全型AIS和不完全型AIS,其原因主要是雄激素受体(androgen receptor,AR)基因的突变导致其对雄激素产生抵抗和不应答。本文回顾南京医科大学附属妇产医院2例CAIS患者的临床资料及诊疗过程,以期能进一步提高对该病的认知及诊治水平。 相似文献
5.
6.
Kei Kamide Yoshihiro Kokubo Hironori Hanada Junko Nagura Jin Yang Shin Takiuchi Chihiro Tanaka Mariko Banno Yoshikazu Miwa Masayoshi Yoshii Tetsutaro Matayoshi Hisayo Yasuda Takeshi Horio Akira Okayama Hitonobu Tomoike Yuhei Kawano Toshiyuki Miyata 《Hypertension research》2006,29(4):243-252
Mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 2, HSD11B2, cause a rare monogenic juvenile hypertensive syndrome called apparent mineralocorticoid excess (AME). In AME, defective HSD11B2 enzyme activity results in overstimulation of the mineralocorticoid receptor (MR) by cortisol, causing sodium retention, hypokalemia, and salt-dependent hypertension. Here, we have studied whether genetic variations in HDS11B2 are implicated in essential hypertension in Japanese hypertensives and the general population. By sequencing the entire coding region and the promoter region of HDS11B2 in 953 Japanese hypertensives, we identified five missense mutations in 11 patients (L14F, n = 5; R74H, n = 1; R147H, n = 3; T156I, n = 1; R335H, n = 1) and one novel frameshift mutation (4884Gdel, n = 1) in a heterozygous state, in addition to 19 genetic variations. All genetic variations identified were rare, with minor allele frequencies less than 0.005. Four of 12 patients with the missense/frameshift mutations showed renal failure. Four missense mutations, L14F, R74H, R147H, and R335H, were successfully genotyped in the general population, with a sample size of 3,655 individuals (2,175 normotensives and 1,480 hypertensives). Mutations L14F, R74H, R147H, and R335H were identified in hypertensives (n = 6, 8, 3, and 0, respectively) and normotensives (n = 8, 12, 5, and 0, respectively) with a similar frequency, suggesting that these missense mutations may not strongly affect the etiology of essential hypertension. Since the allele frequency of all of the genetic variations identified in this study was rare, an association study was not conducted. Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese. 相似文献
7.
Jin Sik Burm 《Journal of plastic, reconstructive & aesthetic surgery》2006,59(3):253-256
This paper describes the use of a composite graft from the mastoid area consisting of full-thickness skin peripherally and selectively localised fascia-fat tissue underneath the skin centrally for immediate reconstruction of moderate defects of the nasal tip including the columella and soft triangle. Mastoid composite grafting is a simple and safe procedure that avoids partial graft loss and provides adequate augmentation of soft tissue, easy reshaping of the new nostril rim, minimal post-operative shrinkage, and no donor-site morbidity. Then, it results in a satisfactory nasal appearance with adequate tip projection and symmetry. This procedure may represent a preferred method of nasal tip reconstruction. 相似文献
8.
目的 探讨Lugol液染色对食管早期癌和癌前病变的诊断价值。方法 对45例食管黏膜可疑病变经内镜以2%Lugol液喷洒染色,观察黏膜染色情况,并取活检送病理组织学检查。结果 45例食管病变染色后,39例呈浅染色或不染色,其中食管癌8例(食管早期癌5例,进展期癌3例),Barrett食管5例,轻至中度不典型增生1l例。本组Lugol液染色对食管早期癌和癌前病变的检出率达46.7%。结论 内镜下应用Lugol液染色结合活检有助于食管早期癌和癌前病变的诊断,且操作简便,具有重要的临床价值。 相似文献
9.
Jin Hwan Ahn Joon Ho Wang Jae Chul Yoo Sung Kon Kim Jung Ho Park Jong Woong Park 《Knee surgery, sports traumatology, arthroscopy》2006,14(12):1288-1291
This article describes a modified suture technique designed for the vertical repair of the anterior horn of the meniscus after arthroscopic decompression of a large meniscal cyst. This procedure comprises of three steps: first, the meniscus was pierced vertically using a suture hook and a No. 0 PDS suture. Second, both ends of the No. 0 PDS on the femoral and tibial surfaces of the meniscus were pulled to the outside of the joint capsule using a spinal needle preloaded with suture material. Finally, a skin incision was made adjacent to the suture materials, and both ends were tied. We recommend this technique not only for the vertical repair of the anterior horn of the meniscus after decompression of large meniscal cyst, but also to repair a longitudinal tear of the meniscus. 相似文献
10.