全文获取类型
收费全文 | 840篇 |
免费 | 55篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 46篇 |
妇产科学 | 2篇 |
基础医学 | 157篇 |
口腔科学 | 4篇 |
临床医学 | 64篇 |
内科学 | 133篇 |
皮肤病学 | 1篇 |
神经病学 | 113篇 |
特种医学 | 72篇 |
外国民族医学 | 3篇 |
外科学 | 132篇 |
综合类 | 23篇 |
预防医学 | 28篇 |
眼科学 | 5篇 |
药学 | 50篇 |
中国医学 | 1篇 |
肿瘤学 | 61篇 |
出版年
2024年 | 2篇 |
2023年 | 4篇 |
2022年 | 8篇 |
2021年 | 30篇 |
2020年 | 24篇 |
2019年 | 19篇 |
2018年 | 25篇 |
2017年 | 11篇 |
2016年 | 27篇 |
2015年 | 35篇 |
2014年 | 42篇 |
2013年 | 48篇 |
2012年 | 79篇 |
2011年 | 70篇 |
2010年 | 44篇 |
2009年 | 39篇 |
2008年 | 40篇 |
2007年 | 44篇 |
2006年 | 38篇 |
2005年 | 51篇 |
2004年 | 44篇 |
2003年 | 35篇 |
2002年 | 30篇 |
2001年 | 15篇 |
2000年 | 19篇 |
1999年 | 11篇 |
1998年 | 9篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 7篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 9篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1970年 | 1篇 |
1967年 | 1篇 |
1961年 | 1篇 |
1928年 | 1篇 |
1915年 | 1篇 |
排序方式: 共有901条查询结果,搜索用时 15 毫秒
1.
Xin Yi Wong Andrew Qi Jun Lim Qianyu Shen John Whay Kuang Chia Min Hoe Chew Wah Siew Tan 《Current medical research and opinion》2020,36(10):1677-1686
Abstract
Objective
Ras wild-type metastatic colorectal cancers (mCRC) may be treated with anti-vascular endothelial growth factor (VEGF) or anti-epidermal growth factor receptor (EGFR) agents. We aim to estimate patients’ preferences for mCRC treatment and relative importance of cost, efficacy improvement, avoidance of side effects and therapy convenience, and relative uptake between profiles that resemble Bevacizumab (anti-VEGF) and Cetuximab (anti-EGFR), two commonly prescribed mCRC targeted therapies. 相似文献2.
3.
In this text we briefly want to discuss the role of the arthrographic examination of the temporomandibular joint for detection of disc pathology. We will mention the normal anatomy and function of the temporomandibular joint, the technique for performing arthrograms and the classification of the most frequent disc pathology. This will be illustrated by some arthrographic examples of anterior disc displacement without reduction, disc perforation, and medial disc displacement. Finally the advantages of arthrography in comparison with other investigation techniques will be discussed. 相似文献
4.
Microsatellite alterations in hepatocellular carcinoma and intrahepatic cholangiocarcinoma 总被引:1,自引:0,他引:1
A series of 20 hepatocellular carcinomas and 8 intrahepatic cholangiocarcinomas was screened from the Korean population for microsatellite alterations, including a loss of heterozygosity and replication errors using nine microsatellite markers containing several genes. The microsatellite results and our previous comparative genomic hybridization results of two tumors were compared at each locus, and the correlations between these and clinicopathologic variables were examined. The most characteristic findings were found at 13q. Replication errors were prevalent at D13S160 (13q21.2 approximately q31) and D13S292(13q12). The incidence of loss of heterozygosity, however, was higher at D13S153 (13q14.1 approximately q14.3) and D13S265(13q31 approximately q32). In contrast, there were higher deletion frequencies observed in hepatocellular carcinoma (HCC) and higher amplification frequencies observed in intrahepatic cholangiocarcinoma at 13q in our previous comparative genomic hybridization (CGH) study. Higher frequencies of replication errors were observed at D16S408 (13q12 approximately q21) and D16S504(13q23 approximately q24) in the HCC. This study found that significant differences in the patterns of genetic instability of microsatellites were dependent on the chromosomal loci. It is believed that certain genes at altered CGH regions, which are relevant to the development and/or progression of these cancers, are activated by different mutation mechanisms. 相似文献
5.
Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells 总被引:2,自引:0,他引:2
Despite numerous reports on MHC class II expression by T cells from a wide spectrum of mammalian species including humans, the biological relevance of this phenomenon has never been tested with appropriately designed animal models. To address this issue, we developed mouse models in which immature thymocytes are the only positively selecting antigen-presenting cells in the thymus. In these mice, CD4+ T cells were generated with the appropriate maturation phenotype and showed a diverse repertoire of TCR Vbetas. The CD4+ T cells were functionally competent, mediating effective allogeneic responses that involved polyclonal TCR Vbetas. These results suggest that the thymocyte-thymocyte (T-T) interaction operates as an independent pathway for CD4+ T cell selection in the thymi of species with MHC II-positive thymocytes. This T-T interaction appears to be the basis for the generation of donor MHC-restricted CD4+ T cells in xenogeneic hosts. 相似文献
6.
Yu Seong Hyeon Hur Young Hoe Hwang Eu Chang Kim Myung Soo Chung Ho Seok Lee Byung Chan Heo Suk Hee Choi Chan Hwang Jun Eul Bae Woo Kyun Jung Seung Il Kwon Dong Deuk 《International urology and nephrology》2021,53(1):69-75
International Urology and Nephrology - Multidetector computed tomographic urography (MDCTU) is not yet sufficient to be used in the clinical staging of upper tract urothelial carcinoma (UTUC). This... 相似文献
7.
In this study, thirty-eight patients with a variety of upper abdominal diseases were examined with three-dimensional time-resolved
MR angiography (7 sec/data set). Visualisation of arterial and venous anatomy was excellent in the majority of patients. Moreover,
subtraction images could be calculated and organ perfusion could be assessed. It is concluded that this technique opens new
perspectives for a comprehensive evaluation of vascular and parenchymal disease.
Received: 14 April 1998; Revision received: 23 October 1998; Accepted: 9 November 1998 相似文献
8.
9.
Cynthia X. L. Chang Anthony T. Tan Ming Yan Or Kai Yee Toh Pei Yiing Lim Adeline S. E. Chia Thomas M. Froesig Karen D. Nadua Hsueh‐Ling J. Oh Hoe Nam Leong Sine R. Hadrup Adam J. Gehring Yee‐Joo Tan Antonio Bertoletti Gijsbert M. Grotenbreg 《European journal of immunology》2013,43(4):1109-1120
Conditional ligands have enabled the high‐throughput production of human leukocyte antigen (HLA) libraries that present defined peptides. Immunomonitoring platforms typically concentrate on restriction elements associated with European ancestry, and such tools are scarce for Asian HLA variants. We report 30 novel irradiation‐sensitive ligands, specifically targeting South East Asian populations, which provide 93, 63, and 79% coverage for HLA‐A, ‐B, and ‐C, respectively. Unique ligands for all 16 HLA types were constructed to provide the desired soluble HLA product in sufficient yield. Peptide exchange was accomplished for all variants as demonstrated by an ELISA‐based MHC stability assay. HLA tetramers with redirected specificity could detect antigen‐specific CD8+ T‐cell responses against human cytomegalovirus, hepatitis B (HBV), dengue virus (DENV), and Epstein‐Barr virus (EBV) infections. The potential of this population‐centric HLA library was demonstrated with the characterization of seven novel T‐cell epitopes from severe acute respiratory syndrome coronavirus, HBV, and DENV. Posthoc analysis revealed that the majority of responses would be more readily identified by our unbiased discovery approach than through the application of state‐of‐the‐art epitope prediction. This flow cytometry‐based technology therefore holds considerable promise for monitoring clinically relevant antigen‐specific T‐cell responses in populations of distinct ethnicity. 相似文献
10.
Chang Kyu Park Dong Chan Lee Chan Joo Park Jang Hoe Hwang 《Journal of Korean Neurosurgical Society》2013,54(5):423-425
We present a case report to remind surgeons of this unusual complication that can occur in any surgery, even posterior cervical spine surgery under general anesthesia and discuss its causes, treatment methods, and the follow-up results in the literature. The peripheral Tapia''s syndrome is a rare complication of anesthetic airway management. Main symptoms are hoarseness of voice and difficulty of tongue movement. Tapia''s syndrome after endotracheal general anesthesia is believed to be due to pressure neuropathy of the vagus nerve and the hypoglossal nerve caused by the endotracheal tube. To our knowledge, no report has been published or given an explanation for Tapia''s syndrome after posterior cervical spine surgery. Two patients who underwent posterior cervical surgery complained hoarseness and tongue palsy postoperatively. There is no direct anatomical relation between the operation, the vagus nerves and the hypoglossal nerves, and there is no record of displacement or malposition of the endotracheal tube. After several months, all symptoms are resolved. To avoid this problem in posterior cervical spine surgery, we suggest paying special attention to the position of the endotracheal tube to avoid excessive neck flexion before and during the positioning of the patient. 相似文献