全文获取类型
收费全文 | 20600篇 |
免费 | 2044篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 161篇 |
儿科学 | 731篇 |
妇产科学 | 502篇 |
基础医学 | 2728篇 |
口腔科学 | 263篇 |
临床医学 | 2740篇 |
内科学 | 3845篇 |
皮肤病学 | 222篇 |
神经病学 | 2214篇 |
特种医学 | 501篇 |
外科学 | 2204篇 |
综合类 | 804篇 |
一般理论 | 27篇 |
预防医学 | 2760篇 |
眼科学 | 423篇 |
药学 | 1432篇 |
中国医学 | 6篇 |
肿瘤学 | 1131篇 |
出版年
2023年 | 198篇 |
2022年 | 274篇 |
2021年 | 543篇 |
2020年 | 383篇 |
2019年 | 555篇 |
2018年 | 667篇 |
2017年 | 497篇 |
2016年 | 532篇 |
2015年 | 478篇 |
2014年 | 682篇 |
2013年 | 1045篇 |
2012年 | 1322篇 |
2011年 | 1348篇 |
2010年 | 751篇 |
2009年 | 600篇 |
2008年 | 1053篇 |
2007年 | 1145篇 |
2006年 | 1074篇 |
2005年 | 984篇 |
2004年 | 912篇 |
2003年 | 824篇 |
2002年 | 805篇 |
2001年 | 491篇 |
2000年 | 454篇 |
1999年 | 432篇 |
1998年 | 202篇 |
1997年 | 158篇 |
1996年 | 195篇 |
1995年 | 163篇 |
1994年 | 123篇 |
1993年 | 155篇 |
1992年 | 317篇 |
1991年 | 301篇 |
1990年 | 317篇 |
1989年 | 258篇 |
1988年 | 231篇 |
1987年 | 246篇 |
1986年 | 202篇 |
1985年 | 166篇 |
1984年 | 169篇 |
1983年 | 139篇 |
1982年 | 102篇 |
1981年 | 67篇 |
1980年 | 69篇 |
1979年 | 112篇 |
1978年 | 102篇 |
1977年 | 84篇 |
1976年 | 67篇 |
1975年 | 76篇 |
1974年 | 59篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
E. M. Peterman C. Sullivan M. F. Goody I. Rodriguez-Nunez J. A. Yoder C. H. Kim 《Infection and immunity》2015,83(1):430-440
Mitochondria are known primarily as the location of the electron transport chain and energy production in cells. More recently, mitochondria have been shown to be signaling centers for apoptosis and inflammation. Reactive oxygen species (ROS) generated as by-products of the electron transport chain within mitochondria significantly impact cellular signaling pathways. Because of the toxic nature of ROS, mitochondria possess an antioxidant enzyme, superoxide dismutase 2 (SOD2), to neutralize ROS. If mitochondrial antioxidant enzymes are overwhelmed during severe infections, mitochondrial dysfunction can occur and lead to multiorgan failure or death. Pseudomonas aeruginosa is an opportunistic pathogen that can infect immunocompromised patients. Infochemicals and exotoxins associated with P. aeruginosa are capable of causing mitochondrial dysfunction. In this work, we describe the roles of SOD2 and mitochondrial ROS regulation in the zebrafish innate immune response to P. aeruginosa infection. sod2 is upregulated in mammalian macrophages and neutrophils in response to lipopolysaccharide in vitro, and sod2 knockdown in zebrafish results in an increased bacterial burden. Further investigation revealed that phagocyte numbers are compromised in Sod2-deficient zebrafish. Addition of the mitochondrion-targeted ROS-scavenging chemical MitoTEMPO rescues neutrophil numbers and reduces the bacterial burden in Sod2-deficient zebrafish. Our work highlights the importance of mitochondrial ROS regulation by SOD2 in the context of innate immunity and supports the use of mitochondrion-targeted ROS scavengers as potential adjuvant therapies during severe infections. 相似文献
3.
Familial risk and heritability of intellectual disability: a population-based cohort study in Sweden
4.
Joseph M. Northey Kate L. Pumpa Clare Quinlan Ashley Ikin Kellie Toohey Disa J. Smee Ben Rattray 《Journal of Science and Medicine in Sport》2019,22(5):580-585
Objectives
The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.Design
Pilot randomised-controlled trial.Methods
Seventeen female cancer survivors (mean: 62.9 ± 7.8 years) were randomised into three groups: high-intensity interval training (HIIT, n = 6); moderate-intensity continuous training (MOD, n = 5); or wait-list control (CON, n = 6). The HIIT and MOD groups exercised on a cycle ergometer 3 days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen’s d effect sizes were calculated.Results
All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7 ± 13.2% vs 79.4 ± 12.0%; p = 0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d = 1.28) and MOD had a non-significant 5.6% (d = 0.72) increase, compared to CON which had a 2.6% decrease.Conclusions
This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials. 相似文献5.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse
下载免费PDF全文
![点击此处可从《Addiction (Abingdon, England)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
6.
7.
8.
9.
10.
Nawf Sharief Judith E. Kingston Vanessa M. Wright Kate Costeloe 《Pediatric hematology and oncology》1991,8(4):323-327
We describe a familial case of Marfan's syndrome with associated intrathoracic stomach detected during the neonatal period. The patient developed a primitive leukemia at 3 months of age. Acute leukemia in a patient with Marfan's syndrome has not previously been reported. 相似文献