Combined devascularization and proximal splenorenal shunt: is this a better option than either procedure alone?

Background/Purpose We aimed to determine the rationality of pericardial devascularization (PCDV) plus proximal splenorenal shunt (PSRS) for cirrhotic patients with portal hypertension with variceal bleeding, using a duplex sonography study of the effects of the different surgical procedures (PCDV, PSRS, and PCDV + PSRS) on the hemodynamics of the portal system.Methods Ninety-nine patients with cirrhotic portal hypertension and a history of bleeding esophageal varices were studied. These patients were divided into three groups (PSRS group, PCDV group, and PCDV + PSRS group). The hemodynamic parameters of the portal systems of all patients were measured by Doppler color-flow imaging perioperatively.Results In the PSRS group, the postoperative portal venous flow (PVF) and free portal pressure (FPP) decreased by 57 ± 9% and 52 ± 5%, respectively (P < 0.01). In the PCDV group, the postoperative PVF lessened by 8 ± 5% (P > 0.05), and the postoperative FPP was reduced by 19 ± 7% (P < 0.05). In the PCDV + PSRS group, the postoperative PVF and FPP were lowered by 36 ± 8% and 34 ± 10%, respectively (P < 0.05). The postoperative decreases of PVF and FPP in the PCDV + PSRS group were between those of the PSRS and PCDV groups. The differences among these groups were statistically significant (P < 0.05).Conclusions Combined devascularization and splenorenal shunt (PCDV + PSRS) significantly decreases portal venous flow and portal pressure, as well as maintaining hepatopedal flow, thus entailing fewer complications compared to either PCDV or PSRS.     

Resting-state abnormal baseline brain activity in unipolar and bipolar depression

In the present study, we investigated differences in resting-state brain activity in patients with bipolar depression (BD) and unipolar depression (UD) by measuring the amplitude of low-frequency fluctuation (ALFF) of functional magnetic resonance imaging (fMRI) signals. Twenty-one BD and 21 gender-, age-, and education-matched UD patients participated in the fMRI analysis. We compared the differences in the ALFF between the two groups and investigated the correlation between clinical measurements and ALFF in the regions displaying significant group differences. BD subjects displayed significantly decreased ALFF in the left superior parietal lobule and the left posterior insula (l-PI). They also displayed increased ALFF in the right dorsal anterior insula (r-dAI) when compared to the UD group. Moderate negative correlations were found between the Hamilton Depression Rating Scale score (HAMD) and the ALFF in the l-PI for the BD (r=-0.44, P=0.02) and UD (r=-0.45, P=0.02) groups. Our results support the notion that insular subregions may contribute to the precise differentiation between BD and UD.     

Electroencephalogram Brain Connectome: An Approach in Research to Identify the Effect of Acupuncture on Human Brain Wave

Acupuncture has been used for 1000 years, but how it gives therapeutic effect is not completely understood. Integration of brain wave as the central nervous system plays an important role in acupuncture efficacy. To explore the effect of acupuncture stimulation in the central nervous system, it is imperative to decide the adjustments in brain waves that produced because of acupuncture stimulation. Electroencephalogram(EEG) is often used in the acupuncture research area. EEG records spontaneous cerebral activity after some time by positioning electrodes on scalp surface. Using EEG, we can observe the brain connectivity regarding the acupuncture stimulation. An overview regarding the effect of manual acupuncture on human brain wave through EEG observation will be discussed in this review.     

高龄初产妇并发重度子痫前期对母儿影响的临床分析

目的:探讨高龄初产妇并发重度子痫前期对母儿预后的影响。方法:以该院2001年4月～2008年4月收治的重度子痫前期单胎妊娠年龄≥35岁的初产孕妇26例为观察组,同期重度子痫前期单胎妊娠年龄<35岁的初产孕妇107例为对照组,对两组患者资料进行回顾性分析,比较两组孕妇及围生儿的最终结局。结果:观察组内科合并症发生率较对照组高,差异有统计学意义(P<0.05),产后出血、胎盘早剥发生率两组比较差异无统计学意义(P>0.05)。观察组低体重儿出生率、新生儿窒息和围产儿死亡率较对照组高,差异有统计学意义(P<0.05)。结论:高龄初产妇并发重度子痫前期对母儿危害大,应加强产前监护,适时终止妊娠,以改善母儿预后。     

表皮生长因子受体基因突变与非小细胞肺癌的基因靶点药物治疗

进入21世纪伊始,肿瘤治疗的革命正面临着基因分子靶点药物的洗礼,2005年5月美国临床肿瘤年会（ASCO）上首日论文分别是“癌症分子靶向治疗”和讲座“靶向人类癌症的表皮生长因子受体（EGFR）途径”。随着国外分子靶点药物Iressa（gefitinib,ZD1839）两项单药治疗非小细胞肺癌的Ⅱ期临床随机对照研究（IDEAL1和IDEAL2）及后续的扩大研究,证实其有很好的疗效且副作用很小,这引起了国内外医学界的瞩目。     

血清瘦素、脂联素和C反应蛋白与妊娠期糖耐量异常程度的相关性

目的:探讨血清瘦素、脂联素和C反应蛋白与妊娠期糖耐量异常的相关性。方法:选取2010年2～6月90例孕妇为研究对象,将其分为妊娠期糖尿病组30例、糖耐量异常组30例和正常孕妇组30例,将3组孕妇的血清瘦素、脂联素和C反应蛋白水平及孕妇、新生儿不良情况发生率进行比较。结果:妊娠期糖尿病组与糖耐量异常组血清瘦素、C反应蛋白水平、孕妇及新生儿的不良情况发生率均高于正常组,而脂联素水平低于正常组;而妊娠期糖尿病组与糖耐量异常组在这些评估项目也存在一定的差异(P<0.05)。结论:血清瘦素、脂联素和C反应蛋白水平与妊娠期糖耐量异常程度有较大的相关性,可引起孕产妇及新生儿的不良情况发生。     

改良Walker术治疗门静脉高压症术后再出血

根据Ｓｕｇｉｕｒａ术的血流动力学原理．将Ｗａｌｋｅｒ术进行改良，用来治疗门静脉高压症术后再出血．特点是在食道下段较低位量阻断食道静脉血流的同时，又可离断腹段残留或复发的冠状静脉属支．优点是经胸手术回避了前次手术粘连和血管栓塞等矛盾．手术简单省时，适应症宽，近期止血可靠、远期效果良好。本组手术１９例，均为各种手术后再出血者．择期手术１５例无死亡；急症手术４例，死亡１例．总的手术死亡率５．２６％（１／１９）．再手术后的生存时间：９ａ１例，７ａ２例，６ａ１例，４ａ３例，３ａ６例．２ａ３例，１ａ１例．     

Genetic association analyses of fast plasma glucose level in pre-menopausal Chinese women: potential interaction between osteocalcin and oestrogen receptor α

Background: Fasting plasma glucose (FPG) levels are usually tightly regulated within a narrow physiologic range. Variation of FPG levels is clinically important and is strongly heritable. Several lines of evidence suggest the importance of the oestrogen receptor α (ER-α) and osteocalcin (also known as BGP, for bone Gla protein) in determining FPG; however, whether their polymorphisms are associated with FPG variation is not well understood.

Aim: To investigate whether ER-a PvuII and BGP HindIII genetic polymorphisms and their potential interaction are associated with FPG variation.

Subjects and methods: The study subjects were 328 unrelated pre-menopausal Chinese women aged 21 years and over (mean age?±?SD, 33.2?±?5.9 years), with an average FPG of 4.92 (SD?=?0.81). All subjects were genotyped at the ER-α PvuII and BGP HindIII loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).

Results: The ER-α PvuII genotypes were significantly associated with FPG (p?=?0.007). In addition, a significant interaction was observed of the ER-α PvuII polymorphism with BGP HindIII polymorphism on FPG variation (p?=?0.013), although the BGP HindIII polymorphism was not shown to be individually associated with FPG.

Conclusion: The PvuII polymorphism of the ER-α gene and its potential interaction with the HindIII polymorphism of the BGP gene were associated with FPG in pre-menopausal Chinese women.     

Differential cognitive responses to guqin music and piano music in Chinese subjects： an event-related potential study

Objective To compare the cognitive effects of guqin （the oldest Chinese instrument） music and piano music. Methods Behavioral and event-related potential （ERP） data in a standard two-stimulus auditory oddball task were recorded and analyzed. Results This study replicated the previous results of culture-familiar music effect on Chinese subjects： the greater P300 amplitude in frontal areas in a culture-familiar music environment. At the same time, the difference between guqin music and piano music was observed in NI and later positive complex （LPC： including P300 and P500）： a relatively higher participation of right anterior-temporal areas in Chinese subjects. Conclusion The results suggest that the special features of ERP responses to guqin music are the outcome of Chinese tonal language environments given the similarity between Guqin＇s tones and Mandarin lexical tones.     

智能中医诊断信息处理技术研究进展与展望

智能中医诊断信息处理技术作为中医现代化的重要内容,也越来越引起科技界的高度重视。本文就智能中医诊断信息处理技术的研究进展作了系统的介绍,特别是对有关脉象、舌象信息处理及智能中医诊断系统的研究现状,作了较为详细的分析总结,并在此基础上,对未来智能中医诊断信息处理技术的发展趋势,进行了系统的展望,包括建立中医辨证认知逻辑系统、中医诊断智能系统构成技术、中医诊断知识的数据挖掘技术、中医诊断信息获取与分析技术,提出了有建设性意义的观点。