全文获取类型
收费全文 | 32753篇 |
免费 | 1666篇 |
国内免费 | 187篇 |
专业分类
耳鼻咽喉 | 387篇 |
儿科学 | 581篇 |
妇产科学 | 315篇 |
基础医学 | 4178篇 |
口腔科学 | 906篇 |
临床医学 | 2339篇 |
内科学 | 8127篇 |
皮肤病学 | 545篇 |
神经病学 | 2555篇 |
特种医学 | 1228篇 |
外科学 | 5264篇 |
综合类 | 201篇 |
预防医学 | 1218篇 |
眼科学 | 524篇 |
药学 | 2781篇 |
中国医学 | 75篇 |
肿瘤学 | 3382篇 |
出版年
2022年 | 271篇 |
2021年 | 590篇 |
2020年 | 287篇 |
2019年 | 424篇 |
2018年 | 549篇 |
2017年 | 449篇 |
2016年 | 546篇 |
2015年 | 570篇 |
2014年 | 766篇 |
2013年 | 955篇 |
2012年 | 1393篇 |
2011年 | 1501篇 |
2010年 | 858篇 |
2009年 | 744篇 |
2008年 | 1290篇 |
2007年 | 1346篇 |
2006年 | 1360篇 |
2005年 | 1468篇 |
2004年 | 1399篇 |
2003年 | 1366篇 |
2002年 | 1426篇 |
2001年 | 1243篇 |
2000年 | 1382篇 |
1999年 | 1209篇 |
1998年 | 432篇 |
1997年 | 315篇 |
1996年 | 326篇 |
1995年 | 275篇 |
1994年 | 263篇 |
1993年 | 252篇 |
1992年 | 802篇 |
1991年 | 721篇 |
1990年 | 734篇 |
1989年 | 778篇 |
1988年 | 710篇 |
1987年 | 638篇 |
1986年 | 608篇 |
1985年 | 571篇 |
1984年 | 442篇 |
1983年 | 332篇 |
1982年 | 188篇 |
1981年 | 150篇 |
1980年 | 159篇 |
1979年 | 284篇 |
1978年 | 222篇 |
1977年 | 172篇 |
1974年 | 165篇 |
1973年 | 152篇 |
1971年 | 153篇 |
1969年 | 171篇 |
排序方式: 共有10000条查询结果,搜索用时 562 毫秒
1.
2.
3.
4.
Takashi Murakami Naoto Sakamoto Akihito Nagahara 《Journal of gastroenterology and hepatology》2019,34(10):1685-1695
Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated neoplasia pathway, which results in BRAF‐mutated colorectal carcinomas with not only high levels of microsatellite instability but also microsatellite stable. SSA/Ps with advanced histology, including cytological dysplasia or minimally invasive carcinomas, are important lesions because SSA/Ps are considered major contributors to “interval cancers” and these lesions can rapidly become dysplastic or invasive carcinomas. Clinicopathologically, SSA/Ps with dysplasia or invasive carcinoma were associated with advanced age, female sex, and proximal colon. Although SSA/Ps with submucosal invasive carcinoma were smaller and invaded less deeply into the submucosal layer than conventional tubular adenomas with submucosal invasive carcinoma, SSA/Ps with submucosal invasive carcinoma frequently had a mucinous component and exhibited a higher potential for lymphatic invasion and lymph node metastasis. In an SSA/P series, endoscopic characteristics, including (semi)pedunculated morphology, double elevation, central depression, and reddishness, may help accurately diagnose SSA/Ps with advanced histology. Removal of SSA/Ps with dysplasia or invasive carcinoma was recommended. Endoscopic treatment such as endoscopic mucosal resection or endoscopic submucosal dissection is useful for those lesions. However, surgical resection with lymph node dissection might be indicated when SSA/Ps with invasive carcinoma are endoscopically suspected, because these have the high risk of lymph node metastasis. Greater awareness may promote further research into improving the detection, recognition, and complete resection rates of SSA/Ps with dysplasia or invasive carcinoma and reduce the interval cancer rates. 相似文献
5.
6.
7.
Kayoko Minakata Masako Suzuki Hideki Nozawa Kunio Gonmori Kanako Watanabe Osamu Suzuki 《Forensic Toxicology》2006,24(2):83-87
Platinum (Pt) levels were determined in various tissues and body fluids obtained from a patient who died 181 days after cisplatin
overdosing. The symptoms of cisplatin overdose, however, might have almost disappeared by day 40, and the patient’s death
was ascribed to the recurrence of malignant lymphoma. Determination of Pt derived from cisplatin was performed by electrospray
ionization mass spectrometry (ESI-MS) using silver (Ag) as internal standard. Pt and Ag complexed with diethyldithiocarbamate
(DDC) in wetashed blood, and tissue solutions were extracted into isoamyl alcohol, and then acidified with oxalic acid. By
injecting an aliquot of the isoamyl alcohol layer into a mass spectrometer in the direct flow injection mode, the quantitation
was performed using the signals of Pt(DDC)3
+ and Ag(DDC)2
+ at m/z 639 and 403, respectively. The Pt levels ranged from 25ng/ml in blood to 2050ng/g wet weight in the liver of the patient,
indicating that Pt remained at high levels in tissues, even after a period as long as 181 days after cisplatin overdosing. 相似文献
8.
Kazunori Aizawa Takeshi Hanaoka Hiroki Kasai Kaoru Kogashi Setsuo Kumazaki Jun Koyama Hiroshi Tsutsui Yoshikazu Yazaki Noboru Watanabe Osamu Kinoshita Uichi Ikeda 《Hypertension research》2006,29(2):123-128
The phosphodiesterase-5 (PDE-5) inhibitor, sildenafil, has been reported to produce sustained pulmonary vasodilatation in patients with pulmonary hypertension (PH). Recently, vardenafil, a more potent and selective PDE-5 inhibitor than sildenafil, has been approved for the treatment of erectile dysfunction. However, the long-term effects of oral vardenafil in patients with PH are unknown. We studied five consecutive patients with PH; one with primary pulmonary hypertension, two with chronic pulmonary thromboembolism, one with Eisenmenger syndrome (ventricular septal defect) and one with secondary pulmonary hypertension after a ventricular septal defect closure operation. In an acute hemodynamic trial, vardenafil (5 mg) significantly decreased both the pulmonary vascular resistance (PVR) and systemic vascular resistance (SVR) with an increase in cardiac output. In a chronic hemodynamic trial, the maintenance dose of vardenafil (10 to 15 mg) for 3 months significantly decreased the PVR, but not the SVR, with a 20.7% reduction of the PVR/ SVR ratio. Plasma brain natriuretic peptide (BNP) levels were also significantly decreased after 3 months. This pilot study demonstrates that long-term oral vardenafil therapy may be a safe and effective treatment for patients with PH. 相似文献
9.
Salvage of a failed valgus osteotomy for nonunion
of an unstable pertrochanteric fracture is reported.
A valgus intertrochanteric osteotomy was performed for a
failed sliding hip screw fixation of an unstable
pertrochanteric fracture at another institution. Four months
following osteotomy, the fracture was still un-united with
two distal screws of the hip plate broken and a coxa vara
deformity. Reconstruction was performed with a nine-hole
95° angle blade plate and cancellous bone graft, because the
insufficient fixation of the distal fragment was considered to
be the main reason for failure. The osteotomy was healed at
six months post-surgery and the patient reported complete
resolution of symptoms. Intertrochanteric valgus osteotomy
is an effective procedure for mal-union and non-union of
pertrochanteric fracture but stable fixation is required for a
good result. The blade of the angle plate offers good purchase
of the proximal fragment and secures it under rotational
and bending stresses. We recommend that distal fragments
should be fixed with at least seven cortices for this
type of osteotomy. 相似文献
10.
Daisuke Kubota Chizuru Takishima Ken-ichi Ishii Takahiro Kawamura Tomoko Matsumoto Yasuhiro Itsui Eriko Okada Seishin Chin Shinya Oooka Kiichiro Tsuchiya Akihiro Araki Naoya Sakamoto Tatsuya Miyata Takanori Kanai Mamoru Watanabe 《Nihon Shokakibyo Gakkai zasshi》2006,103(9):1044-1049
A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/microl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level. 相似文献