Effects of a proton-pump inhibitor in cystic fibrosis

Most children with cystic fibrosis (CF) show persisting steatorrhoea even when treated with pancreatic enzyme. As a low duodenal pH could be responsible for this persisting fat loss, we evaluated the effects of a proton-pump inhibitor (lansoprazole) on both steatorrhoea and growth parameters in 15 CF patients, aged 3.1–22.6y. Acid steatocrit, anthropometry and dual-energy X-ray absorptiometry were used to evaluate steatorrhoea and the nutritional status before, during and 3 months after stopping lansoprazole treatment (15mg/d for 3 months). Mean ± SD acid steatocrit values decreased from 37.1 ± 8.8% to 28.5 ± 10.6% ( p = 0:02). Significant mean Z -score improvements were found for weight (+0:14; p = 0:02), height (+0:15; p = 0:03), subscapular (+0:61; p = 0:003), supra-iliac (+0:8; p = 0:002) and the sum of the four measured skinfolds (+0:61; p = 0:002). Z -scores deteriorated again after stopping lansoprazole. Fat mass and bone mineral content increased significantly on lansoprazole ( p = 0:008 and p = 0:005, respectively). We conclude that lansoprazole as adjuvant therapy significantly improves both steatorrhoea and the nutritional status in CF children who maintain steatorrhoea while on pancreatic enzymes.     

手法复位辅助垫治疗急性不可复性盘前移位的初步报告

目的　探讨关节腔扩张后手法复位辅助再定位垫治疗颞下颌关节紊乱病急性不可复性盘前移位。方法　 2 %局麻药 2～ 3ml注入关节上腔 ,手法复位解除不可复性前移位的关节盘 ,复位后即刻戴用再定位垫保持良好的盘 突关系。结果　近期临床观察表明 :①开口度恢复 ,最大开口度从治疗前的 2 5 8mm增大到 46 6mm ;②疼痛症状消失 ,疼痛分值视觉模拟尺从治疗前的 2 6 2下降到 0 43;③颞下颌关节功能改善 ,Fricton关节功能障碍指数和颞下颌关节紊乱指数分别从治疗前的 0 337和 0 185下降到 0 0 2 1和 0 0 11。结论　颞下颌关节紊乱病急性不可复性盘前移位药物治疗和理疗无效的情况下 ,关节盘复位辅助定位垫是一有效的治疗方法。远期效果如何尚需进一步观察。     

Comparative study of fracture gap motion in external fixation

Different external fixators demonstrated different motion patterns at the fracture site in AP bending. This indicates that fracture gap motion patterns cannot be predicted from a single value of overall frame stiffness. This type of information may be useful in examining existing theories of fracture healing in response to different types of fracture gap motion.     

醋酸泼尼松龙对髁突软骨急性损伤后修复的影响

目的　研究局部应用糖皮质激素类药物对髁突软骨损伤后修复再生的影响。　方法选用成年雄性大白兔 37只 ,分成 4组。第 1组 :髁突软骨全层损伤后局部应用醋酸泼尼松龙组 ;在兔髁突的前斜面形成直径 2mm的软骨全层缺损 ,局部应用醋酸泼尼松龙 2 5mg。第 2组 :单纯髁突软骨全层损伤组。第 3组 :空白手术对照组。第 4组 :正常对照组。结果　第 1组动物的髁突软骨损伤区骨皮质断端进行性增生 ,术后 12周时 ,原损伤区几乎充满致密骨质 ,表面有纤维组织覆盖。结论　醋酸泼尼松龙可促进髁突软骨损伤后的组织修复