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1.
N. J. GOODERHAM S. MURRAY A. M. LYNCH R. J. EDWARDS M. YADOLLAHI-FARSANI C. BRATT K. J. RICH K. ZHAO B. P. MURRAY S. BHADRESA S. J. CROSBIE A. R. BOOBIS & D. S. DAVIES 《British journal of clinical pharmacology》1996,42(1):91-98
1 Heterocyclic amines are formed in parts per billion levels when meat is cooked.
2 The heterocyclic amines MeIQx and PhIP are efficiently absorbed into the systemic circulation after ingestion of cooked food.
3 We have shown that MeIQx and PhIP, both in vitro and in vivo , are substrates for human hepatic CYP1A2, which exclusively and efficiently catalyses their conversion to genotoxic hydroxylamines.
4 MeIQx and PhIP are promutagens. MeIQx is a very powerful bacterial mutagen whereas PhIP is a more potent mammalian cell mutagen. Using a mammalian cell target gene, hprt , we have shown that PhIP induces a characteristic mutational 'fingerprint'.
5 MeIQx and PhIP are carcinogenic in bioassays. The PhIP mutational 'fingerprint' has been detected in the Apc gene of 5/8 colonic tumours induced by PhIP in rats. 相似文献
2 The heterocyclic amines MeIQx and PhIP are efficiently absorbed into the systemic circulation after ingestion of cooked food.
3 We have shown that MeIQx and PhIP, both in vitro and in vivo , are substrates for human hepatic CYP1A2, which exclusively and efficiently catalyses their conversion to genotoxic hydroxylamines.
4 MeIQx and PhIP are promutagens. MeIQx is a very powerful bacterial mutagen whereas PhIP is a more potent mammalian cell mutagen. Using a mammalian cell target gene, hprt , we have shown that PhIP induces a characteristic mutational 'fingerprint'.
5 MeIQx and PhIP are carcinogenic in bioassays. The PhIP mutational 'fingerprint' has been detected in the Apc gene of 5/8 colonic tumours induced by PhIP in rats. 相似文献
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The two locus problem 总被引:2,自引:2,他引:0
J. H. EDWARDS 《Annals of human genetics》1994,58(2):145-150
The problem of detecting linkage between two loci expressed as similar phenotypes and two or more marker loci from a set of families is discussed and a solution advanced. The term amphigenic is suggested for such conditions. 相似文献
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The use of a visual aid to check anaesthetic machines 总被引:1,自引:0,他引:1
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- 1 A hydrophobic/phospholipid electrophoretic system has been devised which makes possible the analysis of human mitochondrial glycerol phosphate dehydrogenase (E.C. 1.1.99.5, GPDM.
- 2 GPDM has a wide tissue distribution in both adult and foetal life and is active in cultured lymphoblastoid cells and fibroblasts but is absent from red cells.
- 3 The solubilization procedure does not significantly alter the kinetic properties of the enzyme (Kmα-glycerophosphate = 0.04-0.07 m , Km PMS = 0.19-0.35 mm ) but the soluble form is less thermostable.
- 4 Comparisons of physicochemical characteristics, tissue distribution and coenzyme requirement point to a separate genetic determination and low level of evolutionary relatedness between GPDM and its cytosolic counterpart GPDs.
9.
Tγδ Cells and their Subsets in Blood and Synovial Tissue from Rheumatoid Arthritis Patients 总被引:10,自引:0,他引:10
M. D. SMITH B. BRÖKER L MORETTA E. CICCONE C. E. GROSSI J. C. W. EDWARDS F. YÜKSEL B. COLACO C. WORMAN L. MACKENZIE R. KINNE G. WESELOH K. GLÜCKERT P. M. LYDYARD 《Scandinavian journal of immunology》1990,32(6):585-593
We have examined the frequencies of T gamma delta cells in blood, synovial fluids, and synovial membranes of patients with rheumatoid arthritis (RA) and in blood from age-matched controls. Immunocytochemical and immunohistochemical techniques were used with monoclonal antibodies BB3 and A13 to define a major and minor blood subset of T gamma delta cells respectively. Together, these antibodies identify the majority (if not all) of the peripheral blood T gamma delta cells. Significantly lower levels of T gamma delta cells were found in the blood of RA patients compared with controls, whilst higher but not significant numbers were found in the synovial fluids of paired samples. Scattered T gamma delta cells were found only in some synovial membranes with a distribution similar to the T alpha beta cells. Analysis of the two different T gamma delta-cell subsets indicated a ratio of BB3 to A13 of about 5:1 in control and RA blood. However, this ratio was less than 1:1 in the RA synovial fluids and membranes. The migratory nature of the A13+ cells could account for their predominance in these sites. The possible pathological significance of these cells in the rheumatoid synovial fluid and synovial membranes is discussed. 相似文献
10.
Inhibition of 3,3',4,4',5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2',4,4',5,5'-Hexachlorobiphenyl 总被引:1,自引:0,他引:1
ZHAO FENG; MAYURA KITTANE; KOCUREK NATHAN; EDWARDS JOHN F.; KUBENA LEON F.; SAFE STEPHEN H.; PHILLIPS TIMOTHY D. 《Toxicological sciences》1997,35(1):1-8
3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose-dependentinduction of chicken embryolethality, malformations, edema,and liver lesions at doses ranging from 0.5 to 12.0 µg/kg.In contrast, no embryotoxicity was observed after treatmentwith 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreatedwith 2.0 µ/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protectionfrom 3,3',4,4',5-pentaCB-induced embryo malformations, edema,and liver lesions, whereas no inhibition of embryolethalitywas observed. These results further extend the response-specificnonadditive interactions of binary mixtures of polychlorinatedbiphenyls (PCBs) and should be considered in the developmentof approaches for hazard assessment of PCB mixtures and relatedcompounds. 相似文献