全文获取类型
收费全文 | 3891篇 |
免费 | 216篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 65篇 |
妇产科学 | 73篇 |
基础医学 | 534篇 |
口腔科学 | 79篇 |
临床医学 | 247篇 |
内科学 | 1045篇 |
皮肤病学 | 74篇 |
神经病学 | 423篇 |
特种医学 | 147篇 |
外科学 | 610篇 |
综合类 | 16篇 |
预防医学 | 117篇 |
眼科学 | 52篇 |
药学 | 203篇 |
中国医学 | 11篇 |
肿瘤学 | 426篇 |
出版年
2023年 | 21篇 |
2022年 | 38篇 |
2021年 | 69篇 |
2020年 | 37篇 |
2019年 | 64篇 |
2018年 | 67篇 |
2017年 | 64篇 |
2016年 | 70篇 |
2015年 | 80篇 |
2014年 | 101篇 |
2013年 | 101篇 |
2012年 | 171篇 |
2011年 | 193篇 |
2010年 | 130篇 |
2009年 | 137篇 |
2008年 | 203篇 |
2007年 | 203篇 |
2006年 | 209篇 |
2005年 | 211篇 |
2004年 | 210篇 |
2003年 | 184篇 |
2002年 | 196篇 |
2001年 | 114篇 |
2000年 | 119篇 |
1999年 | 90篇 |
1998年 | 57篇 |
1997年 | 39篇 |
1996年 | 36篇 |
1995年 | 28篇 |
1994年 | 35篇 |
1993年 | 32篇 |
1992年 | 84篇 |
1991年 | 82篇 |
1990年 | 58篇 |
1989年 | 71篇 |
1988年 | 58篇 |
1987年 | 61篇 |
1986年 | 63篇 |
1985年 | 60篇 |
1984年 | 34篇 |
1983年 | 37篇 |
1982年 | 13篇 |
1981年 | 11篇 |
1979年 | 23篇 |
1978年 | 22篇 |
1977年 | 24篇 |
1972年 | 10篇 |
1969年 | 18篇 |
1968年 | 21篇 |
1966年 | 10篇 |
排序方式: 共有4131条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Kiyotaka YOH Makoto TAHARA Kenji KAWADA Hirofumi MUKAI Masanobu NAKATA Kuniaki ITOH Mitsuhiko KAWASHIMA Hideki NISHIMURA Ryuichi HAYASHI Takashi OGINO Hironobu MINAMI 《Asia-Pacific Journal of Clinical Oncology》2006,2(4):180-184
Background: Olfactory neuroblastoma is a rare sino‐nasal tumor arising from the olfactory epithelium and is often characterized by local invasion or metastasis. The role of chemotherapy in the treatment of this tumor is unclear. The purpose of this study was to review our institution’s experience of chemotherapy for advanced or recurrent olfactory neuroblastoma. Methods: Twenty‐one patients with histologically proven olfactory neuroblastoma were treated at our institution between 1992 and 2002. Twelve of these patients received chemotherapy in the setting of unresectable or recurrent disease and were retrospectively reviewed for clinical characteristics, treatment outcome or survival. Results: Eight patients of the 12 patients received cisplatin‐based chemotherapy and the remaining four patients received chemotherapy consisting of docetaxel plus irinotecan (three patients) or cyclophosphamide, doxorubicin, and vincristine (1 patient). A partial response was achieved in five patients, with an overall response rate of 42%, although the chemotherapeutic regimens were heterogeneous. Two partial responses were obtained among the three patients who received docetaxel plus irinotecan. The response rate to chemotherapy was 83% in the younger age group (<40 years), as opposed to 0% in the older age group (≥40 years), and the difference between the two groups was statistically significant (P = 0.02). Conclusion: Our study indicated that olfactory neuroblastoma would be sensitive to chemotherapy, especially with young patients. Docetaxel plus irinotecan has the possibility of showing favorable response, and warrants further investigation. 相似文献
5.
6.
M H Pietraszek S Takahashi Y Takada K Ohara H Inatomi N Kondo K Ohara A Takada 《Thrombosis research》1991,64(2):243-252
Diurnal changes of serotonin-related factors in whole blood and fibrinolytic activity were determined in depressed patients and healthy controls. Whole blood serotonin concentration of depressed patients showed marked changes throughout daytime, with maximum values in the evening and lowest values in the morning, whereas its metabolite 5-HIAA followed a contrary pattern. The circadian rhythm of 5-HT and 5-HIAA in the control group was quite different from depressed patients. Plasma levels of tPA decreased from 12:30 to 16:30. Concentrations of free plasminogen activator inhibitor (PAI-1) and complex of tPA-PAI-1 decreased from 8:30 to 16:30. Plasma levels of total PAI-1 decreased from 8:30 to 16:30. Plasma levels of the fibrinolytic parameters may be lower in depressive patients than in normal controls. These results support the changes in the circadian rhythm of serotonin and its related substances in the blood of depressive patients. 相似文献
7.
We investigated the effects of imaging and display conditions on the detectability of low-contrast objects in digital subtraction angiographic (DSA) images. The test images were produced by superimposition of low-contrast objects on a uniform noisy background obtained with a DSA system. We employed 18-alternative forced-choice (18-AFC) experiments and predictions based on statistical decision theory to study the dependence of the threshold contrasts of the test objects on the object size, incident x-ray exposure, display window width, and display medium. The results indicated that the threshold contrast decreased with increasing object size, and that the detectability of an object of a given size increased with increasing incident x-ray exposure and decreasing width of the display window. We found that the signal-to-noise ratio (SNR) obtained from the perceived statistical decision theory model, which includes the observer's internal noise, can accurately predict the detectability of low-contrast objects in DSA images. The threshold SNR corresponding to 50% correct detection in the 18-AFC experiments had a constant value of 3.8, in agreement with results reported previously for screen-film systems. The theoretical model will be useful for prediction of the performance of a DSA system based on its physical characteristics, and for evaluation of the tradeoff between patient exposure and diagnostic accuracy for a given DSA unit. 相似文献
8.
We report an 80-year-old Japanese male with four primary malignant tumors: malignant melanoma, prostatic cancer, malignant lymphoma, and renal cell carcinoma, which occurred in that respective order. The combination of malignant melanoma and malignant lymphoma is rare. The patient was treated with BCG after an operation for malignant melanoma. He was also treated with cobalt 60 irradiation after an operation for prostatic cancer. We also discuss other reports of multiple malignant tumors and suggest some possible causes of this patient's primary malignant tumors. 相似文献
9.
10.