全文获取类型
| 收费全文 | 11383篇 |
| 免费 | 737篇 |
| 国内免费 | 45篇 |
专业分类
| 耳鼻咽喉 | 88篇 |
| 儿科学 | 215篇 |
| 妇产科学 | 190篇 |
| 基础医学 | 1751篇 |
| 口腔科学 | 383篇 |
| 临床医学 | 1136篇 |
| 内科学 | 2042篇 |
| 皮肤病学 | 206篇 |
| 神经病学 | 1322篇 |
| 特种医学 | 711篇 |
| 外科学 | 1995篇 |
| 综合类 | 52篇 |
| 一般理论 | 2篇 |
| 预防医学 | 390篇 |
| 眼科学 | 259篇 |
| 药学 | 620篇 |
| 中国医学 | 18篇 |
| 肿瘤学 | 785篇 |
出版年
| 2023年 | 92篇 |
| 2022年 | 188篇 |
| 2021年 | 442篇 |
| 2020年 | 234篇 |
| 2019年 | 280篇 |
| 2018年 | 369篇 |
| 2017年 | 277篇 |
| 2016年 | 412篇 |
| 2015年 | 466篇 |
| 2014年 | 557篇 |
| 2013年 | 585篇 |
| 2012年 | 940篇 |
| 2011年 | 885篇 |
| 2010年 | 538篇 |
| 2009年 | 490篇 |
| 2008年 | 719篇 |
| 2007年 | 642篇 |
| 2006年 | 587篇 |
| 2005年 | 537篇 |
| 2004年 | 483篇 |
| 2003年 | 428篇 |
| 2002年 | 330篇 |
| 2001年 | 116篇 |
| 2000年 | 137篇 |
| 1999年 | 138篇 |
| 1998年 | 55篇 |
| 1997年 | 52篇 |
| 1996年 | 30篇 |
| 1995年 | 39篇 |
| 1994年 | 29篇 |
| 1993年 | 28篇 |
| 1992年 | 59篇 |
| 1991年 | 49篇 |
| 1990年 | 59篇 |
| 1989年 | 62篇 |
| 1988年 | 48篇 |
| 1987年 | 34篇 |
| 1986年 | 28篇 |
| 1985年 | 49篇 |
| 1984年 | 31篇 |
| 1979年 | 27篇 |
| 1978年 | 22篇 |
| 1977年 | 23篇 |
| 1974年 | 27篇 |
| 1971年 | 26篇 |
| 1970年 | 22篇 |
| 1880年 | 32篇 |
| 1879年 | 21篇 |
| 1877年 | 21篇 |
| 1876年 | 21篇 |
排序方式： 共有10000条查询结果，搜索用时 93 毫秒
1.
2.
3.
Paul J. Devlin Brian W. McCrindle James K. Kirklin Eugene H. Blackstone William M. DeCampli Christopher A. Caldarone Ali Dodge-Khatami Pirooz Eghtesady James M. Meza Peter J. Gruber Kristine J. Guleserian Bahaaladin Alsoufi Linda M. Lambert James E. O&#x;Brien Erle H. Austin Jeffrey P. Jacobs Tara Karamlou 《The Journal of thoracic and cardiovascular surgery》2019,157(2):684-695.e8
Objective
Arch obstruction after the Norwood procedure is common and contributes to mortality. We determined the prevalence, associated factors, and practice variability of arch reintervention and assessed whether arch reintervention is associated with mortality.Methods
From 2005 to 2017, 593 neonates in the Congenital Heart Surgeons' Society Critical Left Heart Obstruction cohort underwent a Norwood procedure. Median follow-up was 3.7 years. Multivariable parametric models, including a modulated renewal analysis, were performed.Results
Of the 593 neonates, 146 (25%) underwent 218 reinterventions for arch obstruction after the Norwood procedure: catheter-based (n = 168) or surgical (n = 50) at a median age of 4.3 months (quartile 1-quartile 3, 2.6-5.7). Interdigitation of the distal aortic anastomosis was protective against arch reintervention. Development of ≥ moderate tricuspid valve regurgitation and right ventricular dysfunction at any point was associated with arch reintervention. Nonsignificant variables for arch reintervention included shunt type and preoperative aortic measurements. Surgical arch reintervention was protective against arch reintervention, but transcatheter reintervention was associated with increased reintervention. Arch reintervention was not associated with increased mortality. There was wide institutional variation in incidence of arch reintervention (range, 0-40 reinterventions per 100 years patient follow-up) and in preintervention gradient (range, 0-64 mm Hg).Conclusions
Interdigitation of the distal aortic anastomosis during the Norwood procedure decreased the risk of arch reintervention. Surgical arch reintervention is more definitive than transcatheter. Arch reintervention after the Norwood procedure is not associated with increased mortality. Serial surveillance for arch obstruction, integrated with changes in right ventricular function and tricuspid valve regurgitation, is recommended after the Norwood procedure to improve outcomes. 相似文献4.
Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma
5.
Stefan Scholz Florian Koerber Kinga Meszaros Rosa Maya Fassbender Bernhard Ultsch Robert R. Welte Wolfgang Greiner 《Vaccine》2019,37(12):1692-1701
Introduction
Invasive meningococcal disease (IMD) is a severe disease mainly affecting infants and young children. The most common serogroup causing IMD in Germany is the serogroup type B Neisseria meningitidis (MenB). The aim of the present study is to estimate the economic burden of MenB-related IMD in Germany.Method
A bottom-up, model-based costing approach has been used to calculate the diagnose- and age-specific yearly lifetime costs of a hypothetical cohort of MenB-related IMD cases. Direct costs contain the treatment cost for the acute phase of the disease, long-term sequelae, costs for rehabilitation, and public health response. Indirect costs are calculated for the human-capital approach and the friction-cost approach considering productivity losses of patients or parents for the acute phase and long-term sequelae. Publicly available databases from the Federal Statistical Office, the SOEP panel data set, literature, and expert opinion were used as data sources. All future costs beyond the reference year of 2015 were discounted at 3%.Results
The total costs for the hypothetical cohort (343 patients) from a societal perspective are €19.6 million (€57,100/IMD case) using the friction-cost approach and €58.8 million (€171,000/IMD case) using the human-capital approach. Direct costs amount to €18.6 million or €54,300 €/case. Sequelae are responsible for 81% of the direct costs/case.Discussion
The elevated costs/MenB-related IMD case reflect the severity of the disease. The total costs are sensitive to the productivity-loss estimation approach applied. MenB is an uncommon but severe disease; The costs/case reflect the severity of the disease and is within the same magnitude as for human papilloma virus infections. The available literature on sequelae is due to the uncommonness limited and heterogeneous. 相似文献6.
7.
8.
9.
10.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217