Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial

The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator-blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish-and-spit medication for 5 min three times daily) or a corticosteroid oral paste (triamcinolone acetonide). The duration of treatment was 6 weeks. Thereafter, patients on corticosteroid therapy were treated with CyA. Only slight, transient clinical improvement was observed in both groups after 6 weeks of treatment, compared with baseline. No significant differences could be demonstrated between the two groups. CyA therapy following corticosteroid treatment did not produce any further clinical improvement. During follow-up of the disease for up to 1 year after treatment, neither the CyA nor the corticosteroid group exhibited long-term improvement in disease activity. Contradictory results from earlier reports are discussed.     

18三体及正常NMRI小鼠腭皱发育的形态学研究

目的 通过对18三体伴及不伴腭裂NMRI胚鼠和正常胚鼠的腭皱形态的比较形态学观察研究，认识其腭皱发育的不同特点。方法 60只Han-NMRI母鼠及11只具有Rb(2.18)6Rma/Rb(1.18)Rma染色体结构的雄鼠被用于该研究，从569只子代活胚中选择82只整倍体鼠胚，17只18三体不伴腭裂鼠胚和32只18三体伴腭裂鼠胚，对其腭皱形态进行形态学观察和分类。结果 非腭裂小鼠腭皱有四种不同的表现型，整倍体小鼠腭皱表型以I类为主，18三体小鼠腭皱则以IV类多见，18三体伴腭裂小鼠腭皱有两种不同类型，其中以I类多见，结论 18三体小鼠的过量基因不仅可导致其子代腭裂发生率的增高，也使其腭皱发育呈现明显的不连续及个别缺失畸形，18三体不伴腭裂小鼠的腭皱发育与正常NMRI小鼠有明显区别。