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The present report describes experimental studies on the proteolytic activity of the secretion on the surface of okra pods and the allergenicity of okra components, to clarify the etiology of skin lesions due to okra. Proteolytic activity was detected on the surface of immature okra pods and seemed to be sufficient to cause the skin lesions. Further, in vivo, intradermal injection of the enzyme solution prepared from immature okra pods led to increased capillary permeability in guinea pigs, in contrast to heated preparations. The fraction purified by preparative paper chromatography from an ethyl acetate extract of okra pods showed moderate allergenicity in the guinea pig maximization test. The present experimental evidence supports our suggestions from previous surveys that the proteolytic enzyme of okra may be responsible for development of skin lesions, and that allergic contact dermatitis may also play a part in addition to irritant contact dermatitis. 相似文献
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S. Ui L. Heng H. Yatsuya L. Kawaguichi H. Akashi A. Aoyana 《Critical public health》2010,20(1):97-115
Cambodia's health policy emphasizes community participation to improve health services. This study identifies factors facilitating community participation in health center management in rural Cambodia, focusing on roles of local NGOs. We conducted a questionnaire survey of 50 local NGOs regarding their understanding of new health systems and policies and NGO collaboration with health centers. Eight local NGOs and their partner health centers were selected for further field survey. Using an assessment tool developed by the authors, structured interviews were conducted with 35 stakeholders to measure the level of community participation in the management of health centers through health committees mandated for each health center by the new health policy. Roles and approaches of the eight NGOs were examined. Levels of community participation at the health centers varied and were associated with roles of the partner NGOs. Critical roles of NGOs in facilitating community participation were found to include: nurturing a base through community organizing and capacity building, and encouraging the community to apply community experiences in health; regularly communicating with, monitoring and providing management support to health centers; and linking local actors for health. To take such roles effectively, long-term commitments to specific localities and small financial inputs were found to be advantageous characteristics for NGOs. Local NGOs, even those without health expertise and with limited resources, can effectively promote and facilitate community participation in health center management. Such roles of local NGOs are critically important for sustainable health development, and therefore, should be further recognized and supported. 相似文献
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