68例眼梅毒患者临床诊断的文献分析及其防治对策

目的:分析眼梅毒患者的临床诊断特征,为临床防治眼梅毒提供参考。方法:通过计算机检索中国知网(CNKI)、万方数据库(Wangfang Data)等数据库中"眼梅毒""临床诊断""抗梅毒治疗""梅毒螺旋体""视神经炎""视神经萎缩"等关键词,搜索近10年内国内外关于眼梅毒有关的文献资料,采用Excel 2007版和SPSS 20.0版统计学软件,分析其眼科相关检查和皮肤科相关检查,以及腰椎穿刺的病理学检查结果。结果:阅读全文根据纳入标准和有效信息的提取最终纳入12篇文章涉及68例患者,多以眼后段病变为主,其中视神经萎缩占多数。结论:梅毒的眼部损害为多种多样,缺乏特异性;对于病因不明的视力下降、眼部炎症等病症应排除眼梅毒的存在;梅毒应作为视神经炎的一个鉴别因素,一旦被确诊为眼梅毒,则应按照神经梅毒临床路径采用规范化的抗梅毒治疗。     

12例神经梅毒临床症状与疗效分析

目的:评估抗梅毒治疗对神经梅毒患者的临床疗效.方法:回顾性分析2017年6月至2019年9月期间在我科住院的12例神经梅毒患者,对比治疗前后血RPR滴度及脑脊液白细胞计数、蛋白量、RPR滴度,评估治疗前后患者病情是否改善.结果:12例患者治疗后血RPR滴度从5.50±1.98下降至4.25±1.87,差异有统计学意义(...     

三乙醇胺乳膏治疗皮肤溃疡的多中心研究北大核心CSCD

目的探讨三乙醇胺乳膏治疗皮肤溃疡的安全性和有效性。方法多中心、随机、单盲及阳性药平行对照研究。选取年龄为18～65岁皮肤溃疡的患者,按试验组和对照组2：1分配,总共120例。试验组使用三乙醇胺乳膏,对照组使用重组牛碱性成纤维细胞生长因子凝胶。观察溃疡愈合率、上皮形成率、肉芽生成率等指标,观察期为4周。结果随着治疗时间的延长,两组患者的病情均得到改善。治疗4周时,试验组80例,完成76例;对照组40例,完成38例。痊愈率：试验组为71．05％,对照组为34．21％,P=0．0002;上皮形成率：试验组为66．25％,对照组为37．5％,P=0．0035;肉芽生成率：试验组为85％,对照组为50％,P=0．0001。两组患者均未发现与药物相关的不良事件。结论三乙醇胺乳膏在溃疡愈合率、上皮形成率、肉芽生成率等方面优于重组牛碱性成纤维细胞生长因子凝胶的对照组,是治疗皮肤溃疡一种较好的外用药物。     

复发性生殖器疱疹患者血清可溶性PD-1的表达和免疫学意义

Objective To determine the concentration of soluble PD-1 (sPD-1) in the sera of patients with recurrent genital herpes (RCH), and to explore the significance of abnormal expression of sPD-1 in RCH. Methods Serum samples were obtained from 88 healthy blood donors, 74 patients with RCH including 34 cases of outbreak-stage RCH and 40 cases of stable-stage RCH. The serum level of sPD-1 was measured by monoclonal antibody labeling and enzyme linked immunosorbent assay (ELISA). Results A significant difference was observed in the serum level of sPD-1 between the patients with RGH and the blood donors (33.06 ± 17.5 μg/L vs. 53.07 ± 26.3μg/L, P < 0.01) and between the patients with outbreak-stage RGH and those with stable-stage RGH (27.47 ± 12.9 μg/L vs. 37.71 ± 19.6 μg/L, P< 0.01). Conclusions There is a low expression of sPD-1 in patients with RGH, which may be one of the mechanisms underlying the escape of HSV- Ⅱ from immunologic surveillance and development of immunological tolerance.     

复发性生殖器疱疹患者血清可溶性PD-1的表达和免疫学意义

目的检测复发性生殖器疱疹(RGH)患者血清中可溶性PD-1(sPD-1)蛋白的浓度,探讨sPD-1的异常表达在HSV-Ⅱ病毒感染中的意义.方法选择74例RGH患者,其中发作期RGH患者34例,稳定期RGH患者40例,同时选择88例健康献血者作为对照组;应用单克隆抗体标记、ELISA法检测sPD-1的表达情况.结果 RGH组血清sPD-1蛋白水平为(33.06±17.5)μg/L,低于对照组sPD-1水平(53.07±26.3)μg/L,两者比较差异有统计学意义(t=5.78,P<0.01).发作期RGH组血清sPD-1蛋白水平为(27.47±12.9)μg/L,稳定期RGH组为(37.71±19.6)μg/L,两组间差异有统计学意义(P<0.01).结论 RGH组血清中sPD-1异常低表达,可能是HSV-Ⅱ逃避机体免疫监视、产生免疫耐受的机制之一.

Abstract：

Objective To determine the concentration of soluble PD-1 (sPD-1) in the sera of patients with recurrent genital herpes (RCH), and to explore the significance of abnormal expression of sPD-1 in RCH. Methods Serum samples were obtained from 88 healthy blood donors, 74 patients with RCH including 34 cases of outbreak-stage RCH and 40 cases of stable-stage RCH. The serum level of sPD-1 was measured by monoclonal antibody labeling and enzyme linked immunosorbent assay (ELISA). Results A significant difference was observed in the serum level of sPD-1 between the patients with RGH and the blood donors (33.06 ± 17.5 μg/L vs. 53.07 ± 26.3μg/L, P < 0.01) and between the patients with outbreak-stage RGH and those with stable-stage RGH (27.47 ± 12.9 μg/L vs. 37.71 ± 19.6 μg/L, P< 0.01). Conclusions There is a low expression of sPD-1 in patients with RGH, which may be one of the mechanisms underlying the escape of HSV- Ⅱ from immunologic surveillance and development of immunological tolerance.     

伴多系统损害的早期胎传梅毒1例

<正>1临床资料患儿女,48天。躯干四肢出现红斑15天。患儿为足月剖宫产儿,出生时无异常。出生33天始,躯干及四肢出现红斑,逐渐增多。体检:T37.5℃,P 140次/min,R 45次/min,体质量5kg,神志清,鼻塞,鼻腔内见     

复发性生殖器疱疹患者血清可溶性PD-1的表达和免疫学意义

Objective To determine the concentration of soluble PD-1 (sPD-1) in the sera of patients with recurrent genital herpes (RCH), and to explore the significance of abnormal expression of sPD-1 in RCH. Methods Serum samples were obtained from 88 healthy blood donors, 74 patients with RCH including 34 cases of outbreak-stage RCH and 40 cases of stable-stage RCH. The serum level of sPD-1 was measured by monoclonal antibody labeling and enzyme linked immunosorbent assay (ELISA). Results A significant difference was observed in the serum level of sPD-1 between the patients with RGH and the blood donors (33.06 ± 17.5 μg/L vs. 53.07 ± 26.3μg/L, P < 0.01) and between the patients with outbreak-stage RGH and those with stable-stage RGH (27.47 ± 12.9 μg/L vs. 37.71 ± 19.6 μg/L, P< 0.01). Conclusions There is a low expression of sPD-1 in patients with RGH, which may be one of the mechanisms underlying the escape of HSV- Ⅱ from immunologic surveillance and development of immunological tolerance.     

腹部小汗腺汗孔瘤1例

患者女,59岁.因左下腹部紫红色结节12年,于2010年2月1日来我科就诊.患者于12年前无明显诱因发现左下腹部一紫红色米粒大丘疹,逐渐增生成蚕豆大结节,无疼痛和瘙痒等自觉症状.患者既往体健,家族成员无类似病史.     

某地区104例皮炎湿疹类皮肤病患者斑贴试验结果分析

目的检测和分析苏州地区皮炎湿疹类皮肤病接触变应原。方法采用瑞典进口"瑞敏牌"斑贴试验试剂盒对患者做斑贴试验,并对试验结果、与发病部位及职业等相关因素进行分析。结果 104例皮炎湿疹患者中有59例出现一种或一种以上阳性反应,阳性率为56.73%;变应原阳性率最高的是硫酸镍;手部皮炎湿疹的阳性率最高,达71.43%,以硫酸镍和芳香混合物阳性率最高,其次为泛发全身的(53.33%),以硫酸镍阳性率最高;教师和厨师的阳性率最高。结论斑贴试验可以明确皮炎湿疹类皮肤病患者的接触性致敏原,有助于该类疾病的诊断、治疗以及预防。     

苏州某医院皮肤性病门诊患者4种常见性传播疾病病原体感染状况及原因分析

目的了解某院皮肤性病门诊患者泌尿生殖器Ⅱ型单纯疱疹病毒(HSV-Ⅱ)、解脲脲原体(UU)、沙眼衣原体(CT)、淋病奈瑟菌(NG)的感染情况,为临床防治提供依据。方法采用实时荧光定量聚合酶链反应(QRT-PCR)法对298例疑似HSV-Ⅱ感染者和126例疑似UU、CT、NG感染者进行脱氧核糖核酸(DNA)检测。结果在298例疑似HSV-Ⅱ感染者中,131例HSV-ⅡDNA检测阳性,阳性检出率为43.96%;其中男性阳性检出率为42.61%,女性为48.53%,男女性阳性检出率比较,差异无统计学意义(P>0.05)。<20岁组、20~<40岁组、40~<60岁组、≥60岁组就诊者阳性检出率分别为28.57%、43.02%、47.37%、41.18%,组间比较,差异无统计学意义(χ2=1.239,P>0.05)。126例疑似UU、CT、NG感染者分别进行DNA检测,检出UU阳性65例(51.59%),CT阳性9例(7.14%)和NG阳性10例(7.94%)。不同性别的UU阳性检出率比较,差异有统计学意义(P<0.05);而不同性别的NG和CT阳性检出率比较,差异均无统计学意义(P>0.05)。<20岁组、20~<40岁组、40~<60岁组、≥60岁组UU+CT+NG阳性检出率分别为71.43%、75.00%、32.00%、83.33%,4组间比较,差异有统计学意义(P<0.001)。结论该院皮肤性病门诊就诊者HSV-Ⅱ、UU、CT、NG阳性检出率较高,而病原体检测可辅助临床进行早诊断、早治疗,并为性传播疾病的流行病学研究提供可靠依据。