全文获取类型
收费全文 | 861篇 |
免费 | 30篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 37篇 |
妇产科学 | 73篇 |
基础医学 | 132篇 |
口腔科学 | 3篇 |
临床医学 | 51篇 |
内科学 | 174篇 |
皮肤病学 | 9篇 |
神经病学 | 56篇 |
特种医学 | 24篇 |
外科学 | 50篇 |
综合类 | 12篇 |
预防医学 | 85篇 |
眼科学 | 7篇 |
药学 | 108篇 |
肿瘤学 | 64篇 |
出版年
2023年 | 5篇 |
2022年 | 24篇 |
2021年 | 46篇 |
2020年 | 14篇 |
2019年 | 16篇 |
2018年 | 18篇 |
2017年 | 29篇 |
2016年 | 30篇 |
2015年 | 27篇 |
2014年 | 33篇 |
2013年 | 58篇 |
2012年 | 63篇 |
2011年 | 59篇 |
2010年 | 32篇 |
2009年 | 24篇 |
2008年 | 60篇 |
2007年 | 78篇 |
2006年 | 47篇 |
2005年 | 61篇 |
2004年 | 52篇 |
2003年 | 48篇 |
2002年 | 35篇 |
2001年 | 2篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有895条查询结果,搜索用时 0 毫秒
1.
Urszula Krzych Robert Schwenk Mimi Guebre‐Xabier Peifang Sun Dupeh Palmer Katherine White Isaac Chalom 《Immunological reviews》2000,174(1):123-134
Summary: Exposure to irradiated Plasmodium sporozoites (g‐spz) results in protection against malaria. Like infectious spz, g‐spz colonize hepatocytes to undergo maturation. Disruption of liver stage development prevents the generation of protection, which appears, therefore, to depend on liver stage antigens. Although some mechanisms of protection have been identified, they do not include a role for intrahepatic mononuclear cells (IHMC). We demonstrated that P. berghei g‐spz‐immune murine IHMC adoptively transfer protection to naive recipients. Characterization of intrahepatic CD4+ T cells revealed an immediate, albeit transient, response to g‐spz, while the response of CD8+ T cells is delayed until acquisition of protection. It is presumed that activated CD8+ T cells home to the liver to die; g‐spz‐induced CD8+CD45RBloCD44hi T cells, however, persist in the liver, but not the spleen, during protracted protection. The association between CD8+CD45RBloCD44hi T cells and protection has been verified using MHC class I and CD1 knockout mice and mice with disrupted liver stage parasites. Based on kinetic studies, we propose that interferon‐g, presumably released by intrahepatic effector CD8+ T cells, mediates protection; the persistence of CD8+ T cells is, in turn, linked to Plasmodium antigen depots and cytokines released by CD4+ T cells and/or NK T cells. 相似文献
2.
Jan K. Lacki Kamilla Klama Stefan H. Mackiewicz Urszula Mackiewicz Wolfgang Müller 《Inflammation research》1995,44(1):24-26
In order to evaluate the relationship between serum concentrations of interleukin-10 (IL-10), IL-6, and acute phase proteins in rheumatoid arthritis (RA) patients treated with methotrexate (MTX) or intramuscular gold (IMG) we determined IL-10, IL-6, C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP) and alpha-1-antichymotrypsin (ACT) in the sera of 35 RA patients. IL-10 and IL-6 levels were evaluated using an enzyme-linked immunoassay (ELISA). AGP and ACT level were measured using rocket immunoelectrophoresis. IL-10 serum level was not increased in RA patients as compared to controls (58.7 ± 18.1 pg/ml vs. 57.2 ± 11.9 pg/ml). IL-6 level was significantly elevated (91.6 ± 46.9 pg/ml vs. 45 ± 19 pg/ml, p < 0.05). CRP was significantly increased as compared to healthy controls (35 ± 19 mg/l vs. 3 ± 2 mg/l, p < 0.05). Patients treated with MTX or IMG presented an increased level of IL-10 and decreased amounts of IL-6, as compared to those treated with NSAID only. However, only changes between patients treated with IMG and NSAID were found to be statistically significant. A good negative correlation between IL-10 and IL-6 serum level was found (r = –0.75, p < 0.05). A positive significant correlation between IL-6 serum level and CRP (r = 0.62, p < 0.05), AGP (r = 0.78, p < 0.05) and ACT (r = 0.45, p < 0.05) was established. On the other hand, a negative correlation between IL-10 and serum level of CRP (r = –0.76, p < 0.05), AGP (r = –0.64, p < 0.05) and ACT (r = –0.38, p < 0.05) was also observed. Moreover, these relationships were maintained when patients treated with MTX, IMG, or NSAID were analyzed independently. According to the data thus far obtained, it seems that IL-10 decreases IL-6 production, and thereby indirectly affects the acute phase response, decreasing CRP, AGP, and ACT concentration in RA patients.Abbreviations ACT
-1-antichymotrypsin
- AGP
1-acid glycoprotein
- APP
acute phase protein
- CRP
C-reactive protein
- CSF
colony stimulating factor
- IFN
interferon
- IL
interleukin
- IMG
intramuscular gold
- MTX
methotrexate
- NSAID
non-steroidal anti-inflammatory drug
- RA
rheumatoid arthritis 相似文献
3.
Kuś E Kazimierak W Swierczewski A Kowalska-Koprek U Karowicz-Bilińska A 《Ginekologia polska》2008,79(3):212-217
Le?niowski-Crohn disease is an inflammatory process, involving all layers of the intestine, mesentery and regional lymph nodes. During the development of the disease, a thickening of the intestine wall, stricture of its lumen and adhesions have been observed. The aim of the study was to present the case of a 27-year-old pregnant woman with Crohn's disease, a very rare complication of gestation. 相似文献
4.
Gmyrek GB Sieradzka U Goluda M Gabryś M Sozański R Jerzak M Zbyryt I Chrobak A Chełmońska-Soyta A 《European journal of obstetrics, gynecology, and reproductive biology》2008,137(1):67-76
OBJECTIVE: The pathogenesis of endometriosis is related to functional changes in CD3+ and CD14+ cells observed both at the local and systemic level. Here we investigated whether, and if so, how the body compartment influences cytokine expression in stimulated peritoneal and peripheral CD3+ and CD14+ cells of women with endometriosis. STUDY DESIGN: Isolated peripheral blood (PB) and peritoneal fluid (PF) mononuclear cells from women with endometriosis were cultured under non-adherent conditions and stimulated with PMA and ionomycin for 6h to induce intracellular cytokine synthesis of TNF-alpha, IFN-gamma, and IL-8 by CD3+ cells or with LPS for 9h to produce TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 by CD14+ cells. RESULTS: The percentages of positive CD3+ cells stained for TNF-alpha and IFN-gamma were significantly higher and those stained for IL-8 were significantly lower in PF compared with PB, this being independent of the stage of endometriosis. In contrast, the percentages of CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in PB than PF of women with endometriosis. CONCLUSIONS: Monocytes/macrophages and lymphocytes derived from the peripheral and peritoneal compartments of women with endometriosis differentially respond to stimulated cytokine synthesis induction. However, it is difficult to state whether the observed phenomenon is more related to body compartment influence per se or to the presence of endometriosis. 相似文献
5.
6.
7.
Grzegorz Lis Ewa Cichocka-Jarosz Urszula Jedynak-Wasowicz Edyta Glowacka 《Jornal brasileiro de pneumologia》2014,40(1):82-85
Plastic bronchitis (PB), although a rare cause of airway obstruction, has mortality
rates up to 50% in children after Fontan-type cardiac surgery. We present the case of
an 18-month-old female patient with PB following pneumonia. At 6 months of age, the
patient underwent the Glenn procedure due to functionally univentricular heart.
Fiberoptic bronchoscopy revealed complete blockage of the left bronchus by mucoid
casts. Pharmacotherapy consisted of glucocorticosteroids, azithromycin, and enalapril
maleate. The child also received nebulized 3% NaCl solution, which proved to be
beneficial. In children submitted to Fontan-type procedures, physicians must be alert
for PB, which can be triggered by respiratory tract infection. 相似文献
8.
Wróbel Andrzej Doboszewska Urszula Rechberger Ewa Rojek Karol Serefko Anna Poleszak Ewa Skalicka-Woźniak Krystyna Dudka Jarosław Wlaź Piotr 《Naunyn-Schmiedeberg's archives of pharmacology》2017,390(6):613-619
Naunyn-Schmiedeberg's Archives of Pharmacology - Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors... 相似文献
9.