全文获取类型
收费全文 | 1409篇 |
免费 | 91篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 43篇 |
妇产科学 | 14篇 |
基础医学 | 237篇 |
口腔科学 | 29篇 |
临床医学 | 199篇 |
内科学 | 281篇 |
皮肤病学 | 42篇 |
神经病学 | 139篇 |
特种医学 | 66篇 |
外科学 | 193篇 |
综合类 | 21篇 |
一般理论 | 2篇 |
预防医学 | 75篇 |
眼科学 | 9篇 |
药学 | 93篇 |
中国医学 | 6篇 |
肿瘤学 | 54篇 |
出版年
2022年 | 10篇 |
2021年 | 13篇 |
2020年 | 15篇 |
2019年 | 18篇 |
2018年 | 27篇 |
2017年 | 12篇 |
2016年 | 21篇 |
2015年 | 16篇 |
2014年 | 28篇 |
2013年 | 35篇 |
2012年 | 63篇 |
2011年 | 89篇 |
2010年 | 49篇 |
2009年 | 30篇 |
2008年 | 65篇 |
2007年 | 66篇 |
2006年 | 66篇 |
2005年 | 62篇 |
2004年 | 53篇 |
2003年 | 47篇 |
2002年 | 74篇 |
2001年 | 52篇 |
2000年 | 78篇 |
1999年 | 45篇 |
1998年 | 21篇 |
1997年 | 19篇 |
1996年 | 16篇 |
1995年 | 18篇 |
1994年 | 20篇 |
1993年 | 16篇 |
1992年 | 36篇 |
1991年 | 32篇 |
1990年 | 22篇 |
1989年 | 24篇 |
1988年 | 21篇 |
1987年 | 15篇 |
1986年 | 19篇 |
1985年 | 21篇 |
1984年 | 11篇 |
1983年 | 18篇 |
1982年 | 7篇 |
1979年 | 18篇 |
1978年 | 12篇 |
1977年 | 10篇 |
1976年 | 10篇 |
1975年 | 8篇 |
1972年 | 8篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1969年 | 8篇 |
排序方式: 共有1511条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Amy J Bastian Valerie E Kelly Fredy J Revilla Joel S Perlmutter Jonathan W Mink 《Movement disorders》2003,18(9):1000-1007
The purpose of this study was to determine the effects of unilateral versus bilateral subthalamic nucleus (STN) stimulation on quantitative measures of walking and reaching in Parkinson's disease (PD). We used kinematic measures and the Unified Parkinson's Disease Rating Scale (UPDRS) motor subscale (subscale III) to evaluate the movement of 6 people with PD who had bilateral STN stimulators implanted for at least 6 months and withheld their anti-parkinson medication for at least 8 hours. Subjects were studied with both stimulators off, one on, and both on. Kinematic data were collected as subjects walked, reached to a target, and were rated using the UPDRS motor subscale. STN stimulation improved walking speed and stride length, with the greatest benefit from bilateral stimulation. Reaching speed was improved by unilateral STN stimulation alone, with no additive effect of bilateral stimulation. UPDRS motor subscale ratings paralleled the kinematic findings. STN stimulation did not restore PD subjects' movements to the level of age-matched controls. Overall, these results provide further evidence that the basal ganglia pathways involved in control of walking and reaching may be distinct. We speculate that basal ganglia may influence walking through bilateral pedunculopontine projections and reaching through ipsilateral thalamocortical projections. Our findings also suggest that maximal improvement of walking requires bilateral rather than unilateral STN stimulation. 相似文献
5.
Claudia Breitkopf Ludwig Suter 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1995,46(7):502-504
Zusammenfassung
Bei einer 71j?hrigen Frau trat nach R?ntgenweichstrahltherapie an der Nase (Gesamtdosis 28 Gy, Gewebehalbwerttiefe 10,5–11,5
mm) eine ausgepr?gte Strahlenerosion auf. Diese zeigte 5 Wochen nach Ende der Bestrahlung noch keine Tendenz zur Abheilung.
Ursache dieses ungew?hnlichen Verlaufes war ein gleichzeitig bestehender Pemphigus vulgaris. Dieser hatte sich nach der Strahlentherapie,
vermutlich als Folge einer Freisetzung epidermaler Antigene, verschlimmert. Da? der Pemphigus in diesem Fall durch die Bestrahlung
ausgel?st wurde – wie mehrfach in der Literatur berichtet – ist unwahrscheinlich, aber nicht sicher auszuschlie?en.
Eingegangen am 11. April 1994 Angenommen am 10. Juni 1994 相似文献
6.
7.
Poblete B.; Romand J. A.; Pichard C.; Konig P.; Suter P. M. 《British journal of anaesthesia》1997,78(2):123-127
We have measured the metabolic response to sequential administration of
propacetamol, metamizol and/or external cooling in 20 febrile patients
under sedation and analgesia and during mechanical ventilation. There was
no change in temperature (T degree) after propacetamol therapy, whereas
after metamizol only a small decrease was noted (from 38.9 (SEM 0.2) to
38.5 (0.3) degrees C; P = 0.02). External cooling produced a significant
decrease in T degree (39.1 (0.2) to 37.1 (0.2) degrees C; P < 0.0001)
accompanied by a decrease in energy expenditure (EE) (2034 (73) to 1791
(88) kcal day-1; P < 0.004). Heart rate and minute ventilation decreased
significantly in parallel. There were no other changes in haemodynamics or
pulmonary gas exchanges. We conclude that propacetamol and metamizol did
not produce a clinically significant decrease in T degree in febrile ICU
patients whereas external cooling decreased both T degree and EE. The
parallel decrease in body temperature and EE seemed to be related to opioid
administration or sedation, or both.
相似文献
8.
R Rupprecht A Lippold C Auras G Bramkamp C Breitkopf H-J Elsmann EM Habenicht V Jasnoch H Müller-Pannes K-W Schulte L Suter 《Journal of the European Academy of Dermatology and Venereology》2007,21(2):178-185
Background Cosmetic changes are to be expected after radiotherapy for skin tumours. Objectives This study aimed to answer the questions: How frequent are cosmetic changes after soft X‐ray therapy? Do treatment parameters, tumour thickness, localization and size of the irradiated field have a major influence? Were patients irritated by the visual appearance of the irradiated field? Methods In total, 2474 examinations of 1149 irradiated fields were performed. Results Hypopigmentation was found in 64.7% of examinations more than 90 days after therapy, teleangiectases in 43.1%, erythema in 24.8%, and hyperpigmentation in 16.8%. The frequency of hypopigmentation, teleangiectases and hyperpigmentation increased with time from X‐ray exposure; more than 4 years after therapy hypopigmentation was diagnosed in 91.8% and teleangiectases in 82.2% of examinations. Total dose, the time–dose–fractionation factor (TDF), field size and dose per fraction were significantly related to the frequency of cosmetic changes. Incidence rates of cosmetic changes differed by less than 15% if different treatment conditions were compared: thicker vs. thinner tumours, larger vs. smaller fields, higher vs. lower total doses, doses per fraction, and TDF. Frequencies of hypopigmentation, teleangiectases, erythema and hyperpigmentation differed by more than 15% between some localizations on the head. Women reported irritation by the visual appearance of the irradiated field in 12.6% of 1116 interviews, and men in 4.4% of 1284 interviews. Conclusions Cosmetic changes after soft X‐ray therapy are relatively frequent. Treatment parameters, tumour thickness and field size have only a minor influence. Few patients, but more women than men, were irritated by the visual appearance of the irradiated field. 相似文献
9.
Percutaneous interstitial chemotherapy of a small hepatocellular carcinoma under ultrasound guidance
A small (less than 3 cm) inoperable hepatocellular carcinoma was treated with percutaneous interstitial chemotherapy (PIC). 5-Fluorouracil was injected by a fine needle under ultrasound guidance. After 3 months a fine needle biopsy (FNB) yielded fibronecrotic material. After 18 months another FNB yielded steatosis and dysplastic cells and the lesion showed no increase in size. PIC could be an interesting alternative treatment for small tumors unresponsive to conventional therapies. 相似文献
10.
Art à la Carte is a volunteer program that enables long-term care patients to decorate their hospital room with an art print of their choice. Thirty-seven participants were interviewed to evaluate the program. The data suggest that art adds a personal touch to the sterile hospital environment, facilitates interaction between staff and patients, and provides positive distractions. Choosing a work of art also helps patients to regain a sense of control. These themes coincide with the key components of supportive health care environment. The data suggest that Art à la Carte can provide a meaningful complement to the healing process. 相似文献