全文获取类型
收费全文 | 3373篇 |
免费 | 146篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 55篇 |
妇产科学 | 22篇 |
基础医学 | 426篇 |
口腔科学 | 38篇 |
临床医学 | 216篇 |
内科学 | 1033篇 |
皮肤病学 | 19篇 |
神经病学 | 247篇 |
特种医学 | 142篇 |
外科学 | 591篇 |
综合类 | 15篇 |
预防医学 | 102篇 |
眼科学 | 81篇 |
药学 | 287篇 |
中国医学 | 6篇 |
肿瘤学 | 291篇 |
出版年
2023年 | 30篇 |
2022年 | 33篇 |
2021年 | 76篇 |
2020年 | 33篇 |
2019年 | 51篇 |
2018年 | 53篇 |
2017年 | 67篇 |
2016年 | 67篇 |
2015年 | 57篇 |
2014年 | 95篇 |
2013年 | 122篇 |
2012年 | 185篇 |
2011年 | 196篇 |
2010年 | 88篇 |
2009年 | 90篇 |
2008年 | 180篇 |
2007年 | 221篇 |
2006年 | 198篇 |
2005年 | 230篇 |
2004年 | 216篇 |
2003年 | 204篇 |
2002年 | 229篇 |
2001年 | 97篇 |
2000年 | 80篇 |
1999年 | 60篇 |
1998年 | 37篇 |
1997年 | 28篇 |
1996年 | 36篇 |
1995年 | 48篇 |
1994年 | 19篇 |
1993年 | 24篇 |
1992年 | 38篇 |
1991年 | 44篇 |
1990年 | 40篇 |
1989年 | 42篇 |
1988年 | 31篇 |
1987年 | 28篇 |
1986年 | 24篇 |
1985年 | 14篇 |
1984年 | 14篇 |
1983年 | 16篇 |
1981年 | 7篇 |
1980年 | 11篇 |
1979年 | 14篇 |
1978年 | 8篇 |
1975年 | 9篇 |
1973年 | 11篇 |
1972年 | 12篇 |
1969年 | 8篇 |
1966年 | 8篇 |
排序方式: 共有3576条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Hideki Kawaguchi Kazuko Masuo Tomohiro Katsuya Ken Sugimoto Hiromi Rakugi Toshio Ogihara Michael L Tuck 《Hypertension research》2006,29(12):951-959
High blood pressure (BP) is a major determinant of cardiovascular events in obesity. The beta2- and beta3-adrenoceptor polymorphisms are associated with obesity and hypertension. In the present study, we examine the relationships of beta2- and beta3-adrenoceptor polymorphisms with further weight gain-induced BP elevation in obese subjects. Changes in BP, body weight, total body fat-mass, waist-to-hip ratio, plasma norepinephrine (NE) and leptin levels, and beta2(Arg16Gly)- and beta3(Trp64Arg)-adrenoceptor polymorphisms were measured periodically over a 5-year period in 55 entry obese (body mass index [BMI]> or =25.0 kg/m(2)) normotensive (BP<140/90 mmHg) men. BP elevation and weight gain were defined as > or =10% increases from entry levels over 5 years in mean BP or BMI. Obese subjects with weight gain, BP elevation or weight gain-induced BP elevation had higher frequencies of the Gly16 allele of Arg16GIy and Arg64 allele of Trp64Arg. Subjects carrying the Gly16 or Arg64 alleles had significantly greater total fat-mass and waist-to-hip ratio at entry and over a 5-year period compared to the subjects who did not carry these polymorphisms. Subjects carrying the Gly16 allele had similar levels of plasma NE, higher levels of plasma leptin and a lower slope of the regression lines between plasma leptin and NE levels. Those carrying the Arg64 allele had higher plasma NE levels at entry and over a 5-year period compared to the subjects without the Arg64 allele, but plasma leptin levels and slopes were similar. The findings demonstrate that the Arg64 allele of the beta3-adrenoceptor polymorphisms relates to weight gain-induced BP elevation accompanying high plasma NE (heightened sympathetic activity) in obese men. The Gly16 allele of the beta2-adrenoceptor polymorphisms links to weight gain-induced BP elevation associated with leptin resistance. beta2- and beta3-adrenoceptor polymorphisms could predict the future BP elevation and further weight gain-induced BP elevation in originally obese subjects. 相似文献
5.
6.
Chronological changes in the complement system in sepsis 总被引:6,自引:0,他引:6
The time courses of serum complement levels and the severity of sepsis were compared in two groups of septic patients, one in which the patients survived (surviving group) and one in which they did not (nonsurviving group). The components of the complement system, namely, C3a, C4a, C5a, CH50, C3, C4, and C5, were measured at several points in time after the diagnosis of sepsis had been established. A 2-antibody radioimmunoassay was used to measure C3a, C4a, and C5a; the latex agglutination test was used to measure C3 and C4; nephelometry was used to measure C5; and Meyer's 50% hemolysis method was used to measure CH50. Following the diagnosis of sepsis, the levels of CH50, C3, and C4 were significantly lower in the nonsurviving than the surviving group, while the levels of C3a and C4a were significantly higher in the nonsurviving than the surviving group. The C5a levels were significantly higher in the nonsurviving than the surviving group, although no significant intergroup differences were subsequently noted. These results suggest that the serum levels of C3a, C4a, C5a, CH50, C3, and C4 could serve as indices of the severity of sepsis. Thus, monitoring the complement system may be useful for predicting the outcome of patients with sepsis. 相似文献
7.
8.
We report a rare case of advanced renal cell carcinoma in apatient who showed complete resolution of metastases to thelung and bones after nephrectomy, partial jejunectomy and subsequentalpha-interferon therapy. The patient was a 54-year-old manwhose right lung and left femur metastases were detected beforenephrectomy. In the seventh week after nephrectomy, a partialjejunectomy was carried out because of the obstructive ileuscaused by intraluminal multiple metastases of the jejunum. Apathological fracture of the metastasized right humerus occurredsubsequently. After four months of intramuscular alpha-interferonadministration (3x106 units/day), however, x-rays revealed thecomplete disappearance of the metastatic lung shadow and a solidunion of the humerus, and there were no tumor cells in the femurspecimen resected at the subsequent reconstruction surgery ofthe left leg. Seven years have passed from onset, and the patientis still alive and disease free. 相似文献
9.
Roberto Civitelli M.D. Eturo Ogata Louis V. Avioli Gary Stein Samuel Edelstein John A. Eisman Yasuho Nishii Hajime Orimo Jane Lian Takuo Fujita Yasufumi Hayashi Shigeaki Kato Tadashi Kobayashi Hirotoshi Morii Rikushi Morita Toshitaka Nakamura Yoshiki Seino Masataka Shiraki Tatsuo Suda Naoyuki Takahashi Hideaki Takahashi Tastuhiko Tanisawa Akifumi Tokita 《Calcified tissue international》1995,57(6):409-414
10.
Mechanisms of Cardioprotection by Volatile Anesthetics 总被引:2,自引:0,他引:2
Supported in part by grant HL 《Anesthesiology》2004,100(3):707-721