全文获取类型
收费全文 | 22801篇 |
免费 | 1106篇 |
国内免费 | 142篇 |
专业分类
耳鼻咽喉 | 197篇 |
儿科学 | 274篇 |
妇产科学 | 287篇 |
基础医学 | 2825篇 |
口腔科学 | 388篇 |
临床医学 | 1416篇 |
内科学 | 5997篇 |
皮肤病学 | 393篇 |
神经病学 | 1675篇 |
特种医学 | 1013篇 |
外科学 | 4467篇 |
综合类 | 126篇 |
一般理论 | 1篇 |
预防医学 | 626篇 |
眼科学 | 299篇 |
药学 | 1699篇 |
4篇 | |
中国医学 | 81篇 |
肿瘤学 | 2281篇 |
出版年
2023年 | 140篇 |
2022年 | 293篇 |
2021年 | 505篇 |
2020年 | 256篇 |
2019年 | 351篇 |
2018年 | 429篇 |
2017年 | 367篇 |
2016年 | 471篇 |
2015年 | 469篇 |
2014年 | 583篇 |
2013年 | 730篇 |
2012年 | 1144篇 |
2011年 | 1305篇 |
2010年 | 688篇 |
2009年 | 668篇 |
2008年 | 1079篇 |
2007年 | 1342篇 |
2006年 | 1246篇 |
2005年 | 1244篇 |
2004年 | 1239篇 |
2003年 | 1237篇 |
2002年 | 1208篇 |
2001年 | 553篇 |
2000年 | 526篇 |
1999年 | 539篇 |
1998年 | 340篇 |
1997年 | 287篇 |
1996年 | 239篇 |
1995年 | 217篇 |
1994年 | 173篇 |
1993年 | 191篇 |
1992年 | 417篇 |
1991年 | 351篇 |
1990年 | 362篇 |
1989年 | 328篇 |
1988年 | 320篇 |
1987年 | 314篇 |
1986年 | 298篇 |
1985年 | 226篇 |
1984年 | 160篇 |
1983年 | 159篇 |
1982年 | 68篇 |
1981年 | 66篇 |
1980年 | 52篇 |
1979年 | 123篇 |
1978年 | 65篇 |
1977年 | 61篇 |
1974年 | 58篇 |
1973年 | 64篇 |
1972年 | 67篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
Seven patients with advanced lateral oropharyngeal cancer (T3N2bM0, or T4N2bM0) underwent transoral lateral oropharyngectomy (TLO) with reconstruction performed through set-back tongue flap and polyglycolic acid (PGA) sheet. TLO was performed following en bloc resection of tumors using endoscopy. To cover the resulting defect in the lateral oropharyngeal wall, the set-back tongue flap was moved posteriorly and laterally to the area of the tongue base and lateral pharyngeal wall. The tip of the set-back tongue flap was sutured to the lateral pharynx to reconstruct the elevated tongue base and altered anterior pillar. The defect on the floor of the mouth was reconstructed using a PGA sheet. Following surgery, the mean observation period was 24 months. The mean operating time was 4 h and 2 min, with an average blood loss of 68.1 ml. All oral intake resumed on the first postoperative day via gastric tube. The mean gastric tube removal time was 1.6 postoperative days as a result of sufficient oral intake. None of the patients received postoperative radiotherapy or displayed evidence of tumor recurrence. We conclude that this novel procedure is highly effective for treating advanced oropharyngeal cancer as it demonstrates good prognostic and functional outcomes. 相似文献
4.
Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome. 总被引:5,自引:0,他引:5
Sadao Takahashi Toshiya Tanaka Tatsuhiko Kodama Juro Sakai 《Pharmacological research》2006,53(6):501-507
The development of new treatments for metabolic syndrome is urgent project for decreasing the prevalence of coronary heart disease and diabetes mellitus in the advanced countries. Peroxisome proliferator-activated receptor (PPAR)alpha and gamma agonists have shed light on the treatment of hypertriglyceridemia and type 2 diabetes mellitus, respectively. Among PPARs, analysis of the PPARdelta functions is lagging behind because specific PPARdelta agonists have not been developed. The appearance of new PPARdelta agonists is brightening the prospects for elucidating the physiological role of PPARdelta. PPARdelta is a new target for the treatment of metabolic syndrome. In particular, the fact that fatty acid oxidation and energy dissipation in skeletal muscle and adipose tissue by PPARdelta agonists lead to improved lipid profile, reduced adiposity and insulin sensitivity is a breakthrough. It seems that treatment of PPARdelta agonists operate similarly to the caloric restriction and prolonged exercise. We suggest that the physiological role of PPARdelta may be an indicator for switching from glucose metabolism to fatty acid metabolism. To receive new benefits of PPARdelta agonists against metabolic syndrome by increasing fatty acid consumption in skeletal muscle and adipose tissue, we need to unveil more details on the functions of PPARdelta itself and its agonists in the future. 相似文献
5.
Yuzuru Takemura Haku Ishida Yuji Inoue 《Clinical chemistry and laboratory medicine》2003,41(5):668-674
Few studies have demonstrated the optimal usage of common inflammatory markers, alone or in combination, based on the cost-effectiveness. We analyzed the yield and cost of C-reactive protein (CRP), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), sialic acid, and protein fractionation in 177 new primary care outpatients with inflammation-related symptoms. A useful result (UR) was assigned if tests contributed to a change in physician's diagnosis or decision-making. Costs of testing were calculated based on either single or simultaneous measurement. Five inflammatory markers generated 147 URs in 123 patients. CRP showed the best contribution to generation of UR, followed by sialic acid, protein fractionation, WBC, and ESR. CRP demonstrated poor correlation with WBC (r = 0.458), while sialic acid strongly correlated with total absolute amount of alpha1 and alpha2 fractions in protein fractionation (r = 0.855) and moderately with ESR (r = 0.651). The combination of CRP and WBC produced the best cost-effectiveness at a cost of Yen 1169 (US dollars 9.6 or Euro 9.7)/additional UR against CRP testing alone. Sialic acid, an automated multichannel analyzer-based test, demonstrated the favorable cost-effectiveness over ESR or protein fractionation when combined with CRP (and WBC). Our results indicate that the optimal usage of these inflammatory markers should involve careful cost-effectiveness considerations. 相似文献
6.
7.
Yuji Morimoto Osamu Kemmotsu Koichi Kitami Izumi Matsubara Ichiro Tedo 《Journal of anesthesia》1995,9(1):22-26
We evaluated whether we could predict the neurologic outcome in 55 out-of-hospital cardiac arrest patients using auditory
brainstem responses (ABR). ABR patterns were classified into one of 3 types by evaluation of 5 components: type 1, with all
5 components; type 2, lack of at least one response between the 2nd and 5th components; type 3, with only the first component
or no response. The relation between the ABR patterns on the 3rd day following resuscitation and the neurologic outcome on
hospital discharge was evaluated. The specificity that the 5 awake patients had type-1 ABR was 38%. The sensitivity that the
10 brain dead patients had type-3 ABR was 60%. In the type-1 ABR patients, the negative predictive value that the patients
were awake was 100%. In the type-3 ABR patients, the negative predictive value that the patients became brain dead was 90.9%.
These results suggest that ABR on the 3rd post-resuscitation day may not be useful for predicting if patients are awake or
become brain dead, although the loss of components may be a sign of morbidity, and the presence of the 2nd or later components
indicates possible future prevention of brain death. 相似文献
8.
Y Tomino H Sakai M Miura T Suga M Yagame M Endoh Y Nomoto 《American journal of nephrology》1986,6(3):187-192
A study of double immunofluorescence-staining of immunoglobulins and sialic acids in the glomeruli from patients with IgA nephropathy is described. Renal biopsy specimens from patients with IgA nephropathy were stained with rhodamine-labeled antihuman IgA, IgG or IgM antisera and then stained with FITC-labeled Limulus polyphemus (LPA), Tricum vulgaris (WGA) or antihuman C3 antisera. Marked positive stainings of IgA and C3 and positive binding of LPA or WGA were observed in the glomerular mesangial areas from patients with IgA nephropathy. LPA or WGA were not bound with glomerular capillary walls from patients with moderate and advanced stages of IgA nephropathy, although depositions of IgA and C3 were markedly observed in such walls. There was a significant inverse correlation between the deposition of IgA and the binding of LPA or WGA in glomerular capillary walls obtained from these patients with IgA nephropathy. The levels of proteinuria from patients with moderate and advanced stages of IgA nephropathy were significantly higher than those with minimal and slight stages of such disease. It is suggested that the decrease of sialic acids in glomerular capillary walls might be due to a deposition of IgA in some patients with IgA nephropathy. It is concluded that high levels of proteinuria might be due to the decrease of sialic acids in glomerular capillary walls from patients with moderate and advanced stages of IgA nephropathy. 相似文献
9.
10.
H Nakagawa M Kikuhara M Sato K Sakai S Kimura 《Gan to kagaku ryoho. Cancer & chemotherapy》1987,14(9):2767-2770
A 50-year-old woman with bilateral inflammatory breast cancer (T4, N1b, M1, Stage IV) underwent right extended radical mastectomy and left modified radical mastectomy following pre-operative administration of carcinostatics (ADM, 5-FU) and irradiation. However, tumor recurrence was observed at the skin and right pleural cavity after the operation. Adriamycin-containing combination chemotherapy and radiation therapy were performed, but no significant response was obtained. CDDP was then administered intravenously at a daily dose of 62.5 mg/m2 at intervals of 60 days. The pleural effusion disappeared and the extent of skin metastasis was reduced, resulting in partial response which lasted for 90 days. The serum CEA level decreased from 13.1 ng/ml to 2.3 ng/ml. As the side effects of this therapy, slight nausea, vomiting and general fatigue were observed. This result suggested that CDDP is an effective drug for inflammatory breast cancer. 相似文献