Synthesis,evaluation, and molecular docking studies of aryl urea‐triazole‐based derivatives as anti‐urease agents

Considering the importance of urease inhibitors in the treatment of ureolytic bacterial infections, in this work, the synthesis of novel, aryl urea‐triazole‐based derivatives as effective urease inhibitors is described. Dichloro‐substituted derivative 4o , with IC₅₀ = 22.81 ± 0.05 μM, is found to be the most potent urease inhibitor, determined by Berthelot colorimetric assay. Docking studies were also carried out for compound 4o to confirm the effective interactions with the urease active site.

     

印鼠客蚤Xenopsylla cheopis在新疆的首次发现

为贯彻《国境卫生检疫法》，促进对外贸易的发展和保护人员身体健康，作者对阿拉山口口岸区内的医学动物昆虫进行了本底调查，2001年6月和10月，在褐家鼠（Rattus norvigicus)体表采获印鼠客蚤（Xenopsylla cheopis)2只（1♂，1♀），这是该蚤在新疆的首次发现，具有重要的流行病学意义。