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排序方式: 共有382条查询结果,搜索用时 46 毫秒
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2.
J R Harlé D Quinsat J M Durand N Horchowski M Nicolino S Kaplanski C Farnarier C Fossat M Mongin P J Weiller 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》1989,10(1):25-30
We report a case of large granular lymphocytosis, or chronic "natural killer" lymphocytosis, a newly described entity. We were able to demonstrate the proliferative character of the disease by the finding of karyotype abnormalities. This case was remarkable for the pre-existence, for at least three years, of severe hypogammaglobulinaemia, for the very slow course of the proliferative process and for the progressive and tumoral infiltration of the spleen and liver, then kidney. 相似文献
3.
Duranti R Sanna A Romagnoli I Nerini M Gigliotti F Ambrosino N Scano G 《Pflügers Archiv : European journal of physiology》2004,448(2):222-230
We hypothesized that walking at increased speed or increasing gradient might have different effects on chest wall kinematics and respiratory muscle power components, and contribute differently to respiratory effort sensation. We measured the volumes of chest wall compartments by optoelectronic plethysmography, esophageal, gastric and transdiaphragmatic (P
di) pressures, and the sensation of the respiratory effort by a Borg scale in five normal subjects walking both at ascending gradient with constant speed (AG) and at ascending speed with constant gradient (AS). Chest wall kinematics, evaluated by displacement of chest wall compartments, did not show any significant difference between AS and AG. Muscle power, calculated as the product of mean flow and mean pressure, increased similarly, but its partitioning into pressure and velocity of shortening differed in the two modes. A greater increase in the pressure developed by the abdominal muscles (P
abm) (4.06-fold), and in the velocity of shortening of both rib cage inspiratory muscles (v
rcm,i) (2.01-fold) and the diaphragm (v
di) (1.90-fold) was associated with a lower increase in the pressure developed by the rib cage inspiratory muscles (P
rcm,i) (1.24-fold) and P
di (0.99-fold) with AG. Instead, with AS, a lower increase in P
abm (2.12-fold), v
rcm,i (1.66-fold) and v
di (1.54-fold) was associated with a greater increase in P
rcm,i (1.56-fold) and P
di (1.97-fold). A combination of P
abm and v
di during AG (Wald 2=23.19, P<0.0000), with the addition of P
rcm,i during AS (Wald 2=29.46, P<0.0000), was the best predictor of Borg score. In conclusion, the general strategy adopted by respiratory centers during different walking modes does not differ in terms of ventilation, chest wall kinematics, and respiratory muscle power production, whereas it does in terms of partitioning of power into pressure and velocity of shortening, and respiratory muscle contribution to respiratory effort sensation. Combinations of different patterns of flow and pressure generation made the respiratory effort sensation similar during AS and AG modes. 相似文献
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Sheila Oliveira Angelo Ravelli Angela Pistorio Esteban Castell Clara Malattia Anne Marie Prieur Claudia Saad‐Magalhães Kevin J. Murray Sang‐Cheol Bae Rik Joos Ivan Foeldvari Carolina Duarte‐Salazar Nico Wulffraat Pekka Lahdenne Pavla Dolezalova Jaime de Inocencio Florence Kanakoudi‐Tsakalidou Michael Hofer Irina Nikishina Huri Ozdogan Philip J. Hashkes Jeanne M. Landgraf Alberto Martini Nicolino Ruperto 《Arthritis care & research》2007,57(1):35-43
Objective
To investigate the proxy‐reported health‐related quality of life (HRQOL) and its determinants in patients with juvenile idiopathic arthritis (JIA).Methods
In this multinational, multicenter, cross‐sectional study, HRQOL of patients with JIA was assessed through the Child Health Questionnaire (CHQ) and was compared with that of healthy children of similar age from the same geographic area. Potential determinants of HRQOL included demographic data, physician's and parent's global assessments, measures of joint inflammation, Childhood Health Assessment Questionnaire (CHAQ), and erythrocyte sedimentation rate.Results
A total of 6,639 participants (3,324 with JIA and 3,315 healthy) were enrolled from 32 countries. The mean ± SD physical and psychosocial summary scores of the CHQ were significantly lower in patients with JIA than in healthy children (physical: 44.5 ± 10.6 versus 54.6 ± 4.0, P < 0.0001; psychosocial: 47.6 ± 8.7 versus 51.9 ± 7.5, P < 0.0001), with the physical well‐being domain being most impaired. Patients with persistent oligoarthritis had better HRQOL compared with other subtypes, whereas HRQOL was similar across patients with systemic arthritis, polyarthritis, and extended oligoarthritis. A CHAQ score >1 and a pain intensity rating >3.4 cm on a 10‐cm visual analog scale were the strongest determinants of poorer HRQOL in the physical and psychosocial domains, respectively.Conclusion
We found that patients with JIA have a significant impairment of their HRQOL compared with healthy peers, particularly in the physical domain. Physical well‐being was mostly affected by the level of functional impairment, whereas the intensity of pain had the greatest influence on psychosocial health. 相似文献6.
American College of Rheumatology Provisional Criteria for Global Flares in Childhood‐Onset Systemic Lupus Erythematosus 下载免费PDF全文
Hermine I. Brunner Michael Holland Michael W. Beresford Stacy P. Ardoin Simone Appenzeller Clovis A. Silva Francisco Flores Beatrice Goilav Scott E. Wenderfer Deborah M. Levy Angelo Ravelli Raju Khunchandani Tadej Avcin Marisa S. Klein‐Gitelman Brian M. Feldman Nicolino Ruperto Jun Ying the PRCSG PRINTO Investigators 《Arthritis care & research》2018,70(6):813-822
7.
Céspedes-Cruz A Gutiérrez-Suárez R Pistorio A Ravelli A Loy A Murray KJ Gerloni V Wulffraat N Oliveira S Walsh J Penades IC Alpigiani MG Lahdenne P Saad-Magalhães C Cortis E Lepore L Kimura Y Wouters C Martini A Ruperto N;Pediatric Rheumatology International Trials Organization 《Annals of the rheumatic diseases》2008,67(3):309-314
8.
Winck JC Vitacca M Morais A Barbano L Porta R Teixeira-Pinto A Ambrosino N 《Chest》2004,126(2):382-388
STUDY OBJECTIVES: To compare the tolerance and physiologic effects of a 5-night treatment with either nasal proportional assist ventilation (PAV) or pressure support ventilation (PSV) in patients with chronic ventilatory failure. DESIGN: Cross-over, randomized, controlled study. SETTING: Rehabilitation units of pneumology department. PATIENTS OR PARTICIPANTS: Four patients with COPD and 10 patients with restrictive thoracic diseases with chronic hypercapnia (median baseline Paco(2), 55.1 mm Hg) were studied. INTERVENTIONS: In a cross-over study, nasal PAV and PSV set at the patient's comfort were randomly applied during 5 consecutive nights (with a 2-night washout period). MEASUREMENTS AND RESULTS: Continuous nocturnal pulse oximetric saturation (Spo(2)) and arterial blood gas results at wake-up were evaluated at baseline during spontaneous breathing and on the fifth day of ventilatory support. Dyspnea, sleep quality, adaptation, and comfort at inspiration and expiration by visual analog scale (VAS) were evaluated every day as well as a side effects score. On the fifth day, there were no significant differences in daytime Paco(2) (median PAV, 53.3 mm Hg; median PSV, 50.2; p = 0.168). Mean nocturnal Spo(2) improved significantly with both PAV and PSV without any significant differences between modes (baseline median, 92%; PAV median, 94.5%; PSV median, 95%). The percentage of the study night spent < 90% Spo(2) (T90) was slightly but significantly higher with PAV than with PSV (median PAV T90, 4%; median PSV T90, 2%; p = 0.049). The VAS symptom score was similar at day 5 between modes; however, nasal and oral dryness were lower (p = 0.05) and alarm noise was higher (p = 0.037) with PAV. CONCLUSIONS: After 5 days of treatment, both modes had similar tolerance, and were equally effective in reducing daytime hypercapnia and improving nocturnal saturation and symptoms. However, PAV induced less nasal and oral dryness but was associated with higher alarm noise. 相似文献
9.
Toplak N Frenkel J Ozen S Lachmann HJ Woo P Koné-Paut I De Benedetti F Neven B Hofer M Dolezalova P Kümmerle-Deschner J Touitou I Hentgen V Simon A Girschick H Rose C Wouters C Vesely R Arostegui J Stojanov S Ozgodan H Martini A Ruperto N Gattorno M;Paediatric Rheumatology International Trials Organisation 《Annals of the rheumatic diseases》2012,71(7):1177-1182