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Grifoni Elisa Giglio Davide Guazzini Giulia Cosentino Eleonora Latini Ester Dei Alessandro Del Rosso Attilio Guarnaccia Vincenzo Baldini Mariella Bartolozzi Maria Letizia Martinucci Pietro Sani Francesca Giordano Antonio Dainelli Francesca Maggi Francesca Giulietti Chiara Romagnoli Mario Cinotti Stefano Schipani Elena Murgida Giuseppe Salvatore Di Martino Stefania Cozzi Andrea Carli Ballola Adele Dacomo Debora Valori Debora Masotti Luca 《Journal of thrombosis and thrombolysis》2020,49(1):75-85
Journal of Thrombosis and Thrombolysis - Few data are available on age-related burden and characteristics of embolic stroke of undetermined source (ESUS) in the real world clinical practice. The... 相似文献
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Luciano A. Abriata Damián álvarez-Paggi Gabriela N. Ledesma Ninian J. Blackburn Alejandro J. Vila Daniel H. Murgida 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(43):17348-17353
Electron transfer is the simplest chemical reaction and constitutes the basis of a large variety of biological processes, such as photosynthesis and cellular respiration. Nature has evolved specific proteins and cofactors for these functions. The mechanisms optimizing biological electron transfer have been matter of intense debate, such as the role of the protein milieu between donor and acceptor sites. Here we propose a mechanism regulating long-range electron transfer in proteins. Specifically, we report a spectroscopic, electrochemical, and theoretical study on WT and single-mutant CuA redox centers from Thermus thermophilus, which shows that thermal fluctuations may populate two alternative ground-state electronic wave functions optimized for electron entry and exit, respectively, through two different and nearly perpendicular pathways. These findings suggest a unique role for alternative or “invisible” electronic ground states in directional electron transfer. Moreover, it is shown that this energy gap and, therefore, the equilibrium between ground states can be fine-tuned by minor perturbations, suggesting alternative ways through which protein–protein interactions and membrane potential may optimize and regulate electron–proton energy transduction. 相似文献
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