全文获取类型
收费全文 | 1378篇 |
免费 | 57篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 28篇 |
妇产科学 | 25篇 |
基础医学 | 137篇 |
口腔科学 | 15篇 |
临床医学 | 110篇 |
内科学 | 156篇 |
皮肤病学 | 44篇 |
神经病学 | 83篇 |
特种医学 | 21篇 |
外科学 | 302篇 |
综合类 | 3篇 |
预防医学 | 239篇 |
眼科学 | 14篇 |
药学 | 158篇 |
中国医学 | 5篇 |
肿瘤学 | 84篇 |
出版年
2021年 | 22篇 |
2020年 | 10篇 |
2018年 | 10篇 |
2017年 | 18篇 |
2015年 | 16篇 |
2014年 | 38篇 |
2013年 | 40篇 |
2012年 | 66篇 |
2011年 | 67篇 |
2010年 | 30篇 |
2009年 | 23篇 |
2008年 | 49篇 |
2007年 | 51篇 |
2006年 | 46篇 |
2005年 | 42篇 |
2004年 | 51篇 |
2003年 | 54篇 |
2002年 | 52篇 |
2001年 | 37篇 |
2000年 | 45篇 |
1999年 | 34篇 |
1998年 | 10篇 |
1997年 | 9篇 |
1995年 | 12篇 |
1992年 | 30篇 |
1991年 | 34篇 |
1990年 | 15篇 |
1989年 | 24篇 |
1988年 | 31篇 |
1987年 | 31篇 |
1986年 | 34篇 |
1985年 | 39篇 |
1984年 | 27篇 |
1983年 | 23篇 |
1982年 | 9篇 |
1981年 | 14篇 |
1980年 | 11篇 |
1979年 | 16篇 |
1978年 | 12篇 |
1977年 | 13篇 |
1976年 | 18篇 |
1975年 | 17篇 |
1974年 | 24篇 |
1973年 | 18篇 |
1972年 | 19篇 |
1971年 | 17篇 |
1970年 | 12篇 |
1969年 | 13篇 |
1968年 | 15篇 |
1966年 | 23篇 |
排序方式: 共有1440条查询结果,搜索用时 15 毫秒
1.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献2.
Prof. Dr. Doris Balogh 《European Surgery》1997,29(6):309-311
3.
Mihaly Arato Ed Frecska Duncan J. MacCrimmon Rick Guscott Bishan Saxena Kornelia Tekes Laszlo Tothfalusi 《Progress in neuro-psychopharmacology & biological psychiatry》1991,15(6):759-764
1. Postmortem neurochemical investigations revealed interhemispheric asymmetry in the mediofrontal region of human brain. Significantly higher right hemisphere serotonin metabolite (5HIAA) content as well as increased maximal imipramine binding (IB) were found in the right hemisphere than in the left side.
2. IB did not show a gender difference in the mediofrontal area. However, women had higher IB in the right orbital frontal cortex than did men.
3. In vivo pharmaco-EEG results tend to support the postmortem neurochemical data. Intravenous chlorimipramine resulted in an asymmetric topographic distribution of the P300 auditory evoked potential, peak amplitudes were shifted to the right hemisphere. 相似文献
4.
G Balogh 《Orvosi hetilap》1991,132(38):2075-2080
Experiences obtained with 400 cases of thoracal empyema are described. The fact that the rate of lethality was 18.7% until present points out to the severity of the disease. The semi-conservative therapeutical methods used by the author (drainage, drainage and pleura lavage, pleura lavage and thoracoscopy, balance drainage) are presented. With their sensibly more frequent use the rate of operation could be reduced by 8% (from 36.5% to 28.5%) and the lethality rate by 7.6% (from 18.7% to 11.1). Further improvement of the results may be expected of the increased number of early detection (basic care), concentration of empyemic patients in special institutes (departments, wards) and due to it of a more efficient special treatment of uniform contemplation. 相似文献
5.
6.
R Balogh S Bond K Parker 《Nursing standard (Royal College of Nursing (Great Britain) : 1987)》1992,7(1):35-38
Increasing interest in audit in the health service has focused attention on the tools and methods used to achieve it. These can be extremely expensive, so a tendency to opt for off-the-shelf packages has developed. This article reviews how one such instrument, The Central Nottinghamshire Psychiatric Nursing Audit, has been used in two settings over the past three years, with particular emphasis on its cost-effectiveness. 相似文献
7.
The prolonged effect of nickel chloride and cadmium chloride on the rat fetal myocardium was studied experimentally administered to the pregnant mother through a gastric tube in doses of 12.5 mg/b. wt. It could be demonstrated that, due to nickel administration, changes simulating cardiomyopathy and severe mitochondrial lesions developed and the number of collagenous fibres and glycogen granules accumulated, while as a result of cadmium chloride administration, changes were apparent mainly in the endothelial cells, but with simultaneous mitochondrial impairments, too. Nickel and cadmium are contained by cigarette smoke. Based on experimental studies, authors propose new arguments on the damaging effect of smoking of pregnant women. 相似文献
8.
Robert H. Smallwood George W. Mihaly Richard A. Smallwood Denis J. Morgan 《Journal of pharmacokinetics and pharmacodynamics》1988,16(5):529-542
For substances eliminated from blood by the liver, the effect of a change in unbound fraction of drug (fu
b
)on steady state total (C
b
)and unbound (Cu
b
)blood concentrations has hitherto only been considered for the two limiting cases, i.e., at the upper and lower extremes of hepatic intrinsic clearance (CL
int
).For a substance of very low CL
int
,if fu
b
changes, C
t
will change and Cu
b
will remain constant, whereas if CL
int
isvery high, Cu
b
will change and C
b
will remain constant.The present study defines the effects of a change in fu
b
on C
b
and Cu
b
over the whole CL
int
range. Computer simulations were undertaken which predicted that, for a given change in fu
b
,absolute and relative changes in C
b
would decreasenonlinearly with increasing CL
int, twhile the relative change in Cu
b would increasewith CL
int
.The absolute change in Cub
would be independent of CL
int
.Significant changes in Cb and Cu
b would be observed at intermediate values of CL
int not just at the high and low extremes. These theoretical predictions were investigated experimentally in the isolated perfused rat liver by examining the effects of a change in fu
b of sodium taurocholate a substance with intermediate CL
int
(such that at fu
b
=0.27,hepatic extraction ratio=0.71) induced by concurrent administration of sodium oleate. Sodium 24-
14
C-taurocholate (specific activity 52 Ci/mmol) was infused into the reservoir in a recycling system at 30 mol/hr for 105 min (n=6). At 45 min a bolus dose of sodium oleate (50 mmol) was administered to the reservoir, followed by a constant infusion of 143 mmol/hr for 1 hr. Following the administration of oleate, taurocholate fu
b fell promptly by 55% (0.27–0.12). There was a relative increase of taurocholate C
b of 22.7% and a relative decrease in Cu
b of 45.4%, in accordance with the simulations (p<0.05). We conclude that important changes in unbound steady-state concentration, the pharmacologically active moiety, can occur upon changes in unbound fraction with compounds of intermediate hepatic intrinsic clearance.This study was supported by the National Health and Medical Research Council of Australia. 相似文献
9.
Attila Patocs Peter Gergics Katalin Balogh Miklos Toth Ferenc Fazakas Istvan Liko Karoly Racz 《BMC medical genetics》2008,9(1):29
Von Hippel-Lindau disease (VHL) is a rare autosomal dominant disease characterized by development of cystic and tumorous lesions
at multiple sites, including the brain, spinal cord, kidneys, adrenals, pancreas, epididymis and eyes. The clinical phenotype
results from molecular abnormalities of the VHL tumor suppressor gene, mapped to human chromosome 3p25-26. The VHL gene encodes two functionally active VHL proteins due to the presence of two translational initiation sites separated by
53 codons. The majority of disease-causing mutations have been detected downstream of the second translational initiation
site, but there are conflicting data as to whether few mutations located in the first 53 codons, such as the Pro25Leu could
have a pathogenic role. In this paper we report a large Hungarian VHL type 2 family consisting of 32 members in whom a disease-causing
AGT80AAT (Ser80Ile) c.239G>A, p.Ser80Ile mutation, but not the concurrent CCT25CTT (Pro25Leu) c.74C>T, p.Pro25Leu variant
co-segregated with the disease. To our knowledge, the Ser80Ile mutation has not been previously described in VHL type 2 patients
with high risk of pheochromocytoma and renal cell cancer. Therefore, this finding represents a novel genotype-phenotype association
and VHL kindreds with Ser80Ile mutation will require careful surveillance for pheochromocytoma. We concluded that the Pro25Leu
variant is a rare, neutral variant, but the presence such a rare gene variant may make genetic counseling difficult. 相似文献
10.
Cytogenetic analyses of three papillary carcinomas and a follicular adenoma of the thyroid 总被引:2,自引:0,他引:2
E Olah E Balogh F Bojan F Juhasz V Stenszky N R Farid 《Cancer Genetics and Cytogenetics》1990,44(1):119-129
Cytogenetic data of three papillary carcinomas and a follicular adenoma using direct preparations or cell cultures or both after 7 to 60 days in vitro are presented. Although karyotype of the follicular adenoma proved completely normal, in each of the three papillary carcinomas a modal chromosome number in the diploid range and a deleted 11q were observed. In case 1 the del(11)(q23) was associated with rearrangement of chromosome 1 and other marker chromosomes. Our results suggest that 11q deletion may be specific for papillary carcinoma of the thyroid. 相似文献