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排序方式: 共有93条查询结果,搜索用时 15 毫秒
1.
Drielen De Oliveira Moreira MSci Juliano Alves Pereira MSci Ana Paula Tiemi Taniguti DSci Cíntia Yuri Matsumura DSci Luis Alberto Ferreira Ramos MSci Miguel Arcanjo Areas PhD Humberto Santo Neto PhD Maria Julia Marques PhD 《Muscle & nerve》2013,48(6):911-919
Introduction: The purpose of this study was to determine the effects of suramin, an antifibrotic agent, on cardiac function and remodeling in mdx mice. Methods: mdx mice (8 months old) received intraperitoneal injections of suramin twice a week for 3 months. Control mdx mice (8 months old) were injected with saline. Results: Suramin improved the electrocardiography profile with the main corrections seen in S‐ to R‐wave ratio, PR interval, and Q amplitude, and a significant decrease in the cardiomyopathy index. Suramin decreased myocardial fibrosis, inflammation, and myonecrosis. Conclusions: These findings suggest that suramin may be a new adjunctive therapy to help improve cardiomyopathy in DMD. Muscle Nerve 48 : 911–919, 2013 相似文献
2.
Carlos R. Hernandez‐Castillo PhD Sarael Alcauter PhD Victor Galvez MSci Fernando A. Barrios PhD Petra Yescas PhD Adriana Ochoa Msci Lizbeth Garcia MSci Rosalinda Diaz MSci Wei Gao PhD Juan Fernandez‐Ruiz PhD 《Movement disorders》2013,28(12):1708-1716
Spinocerebellar ataxia type 7 (SCA7) is an autosomal‐dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region‐specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel‐based morphometry and resting‐state fMRI, we studied 26 genetically confirmed SCA7 patients and aged‐matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo‐ and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7. © 2013 International Parkinson and Movement Disorder Society 相似文献
3.
Brenda Happell RN Cert Psych Nurs BA DipEd MEd PhD FACMHN Shifra Waks BA MIHP B Int Global Stud Aine Horgan PhD MSc BNS PGCert T&L RPN Sonya Greaney DipSPH PG Cert Peer Support Fionnuala Manning John Goodwin MA PGDip Bsc BA ALCM DipMgmt RPN Julia Bocking BPhil B Soc & Comm Stud Brett Scholz BHSci PhD Elisabeth Hals MA Arild Granerud PhD Rory Doody B.Soc.Sc. Chris Platania-Phung BA PhD Martha Griffin H. Dip in Community Youth Work Siobhan Russell BSc RPN PhD Liam MacGabhann BSc MSc DrNursSci Jarmo Pulli Annaliina Vatula BA Graeme Browne RN MHN PhD FACMHN Kornelis Jan van der Vaart BN MSci Jerry Allon Einar Bjornsson Heikki Ellilä RN MNSc PhD Mari Lahti MNSc PhD Pall Biering PhD 《Perspectives in psychiatric care》2020,56(4):811-819
4.
M. Angela Cenci MD PhD Sara Riggare MSci Rajesh Pahwa MD David Eidelberg MD Robert A. Hauser MD 《Movement disorders》2020,35(3):392-396
Levodopa-induced dyskinesia (LID) represents a significant source of discomfort for people with Parkinson's disease (PD). It negatively affects quality of life, it is associated with both motor and nonmotor fluctuations, and it brings an increased risk of disability, balance problems, and falls. Although the prevalence of severe LID appears to be lower than in previous eras (likely owing to a more conservative use of oral levodopa), we have not yet found a way to prevent the development of this complication. Advanced surgical therapies, such as deep brain stimulation, ameliorate LID, but only a minority of PD patients qualify for these interventions. Although some have argued that PD patients would rather be ON with dyskinesia than OFF, the deeper truth is that patients would very much prefer to be ON without dyskinesia. As researchers and clinicians, we should aspire to make that goal a reality. To this end, translational research on LID is to be encouraged and persistently pursued. © 2019 International Parkinson and Movement Disorder Society 相似文献
5.
Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2 下载免费PDF全文
6.
Abouch Valenty Krymchantowski MD MSci PhD FAHS Carla da Cunha Jevoux MD MSci PhD 《Headache》2014,54(6):967-975
7.
Ted A. Skolarus MD MPH Andrew M.D. Wolf MD Nicole L. Erb BA Durado D. Brooks MD MPH Brian M. Rivers PhD MPH Willie Underwood III MD MPH MSci Andrew L. Salner MD Michael J. Zelefsky MD Jeanny B. Aragon‐Ching MD Susan F. Slovin MD PhD Daniela A. Wittmann PhD MSW CST Michael A. Hoyt PhD Victoria J. Sinibaldi CRNP Gerald Chodak MD Mandi L. Pratt‐Chapman MA Rebecca L. Cowens‐Alvarado MPH 《CA: a cancer journal for clinicians》2014,64(4):225-249
Answer questions and earn CME/CNE Prostate cancer survivors approach 2.8 million in number and represent 1 in 5 of all cancer survivors in the United States. While guidelines exist for timely treatment and surveillance for recurrent disease, there is limited availability of guidelines that facilitate the provision of posttreatment clinical follow‐up care to address the myriad of long‐term and late effects that survivors may face. Based on recommendations set forth by a National Cancer Survivorship Resource Center expert panel, the American Cancer Society developed clinical follow‐up care guidelines to facilitate the provision of posttreatment care by primary care clinicians. These guidelines were developed using a combined approach of evidence synthesis and expert consensus. Existing guidelines for health promotion, surveillance, and screening for second primary cancers were referenced when available. To promote comprehensive follow‐up care and optimal health and quality of life for the posttreatment survivor, the guidelines address health promotion, surveillance for prostate cancer recurrence, screening for second primary cancers, long‐term and late effects assessment and management, psychosocial issues, and care coordination among the oncology team, primary care clinicians, and nononcology specialists. A key challenge to the development of these guidelines was the limited availability of published evidence for management of prostate cancer survivors after treatment. Much of the evidence relies on studies with small sample sizes and retrospective analyses of facility‐specific and population databases. CA Cancer J Clin 2014;64:225–249. © 2014 American Cancer Society . 相似文献
8.
Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulator NPRL3 下载免费PDF全文
Miriam Fanjul‐Fernández PhD Jessica R. Riseley BSc Greta Gillies MSci Kate Pope BSc Hanna van Roozendaal Bsc Julian I. Heng PhD Simone A. Mandelstam MBChB George McGillivray MBChB Duncan MacGregor MBBS PhD Lakshminarayanan Kannan MBBS Wirginia Maixner MBBS A. Simon Harvey MBBS MD David J. Amor MBBS PhD Martin B. Delatycki MBBS PhD Peter B. Crino MD PhD Melanie Bahlo PhD Richard J. Leventer MBBS PhD 《Annals of neurology》2016,79(1):132-137
We describe first cousin sibling pairs with focal epilepsy, one of each pair having focal cortical dysplasia (FCD) IIa. Linkage analysis and whole‐exome sequencing identified a heterozygous germline frameshift mutation in the gene encoding nitrogen permease regulator‐like 3 (NPRL3). NPRL3 is a component of GAP Activity Towards Rags 1, a negative regulator of the mammalian target of rapamycin complex 1 signaling pathway. Immunostaining of resected brain tissue demonstrated mammalian target of rapamycin activation. Screening of 52 unrelated individuals with FCD identified 2 additional patients with FCDIIa and germline NPRL3 mutations. Similar to DEPDC5, NPRL3 mutations may be considered as causal variants in patients with FCD or magnetic resonance imaging–negative focal epilepsy. ANN NEUROL 2016;79:132–137 相似文献
9.
Relationship ofcampylobacter pylori and duodenogastric reflux 总被引:1,自引:0,他引:1
S. Niemelä MD T. Karttunen MD J. Heikkilä MSci O. Mäentausta MSci J. Lehtola MD 《Digestive diseases and sciences》1989,34(7):1021-1024
We have examined the relationship of Campylobacter -like organism (CLO) and duodenogastric reflux (DGR) in 107 patients with unoperated stomachs. Neither the extent of externally measured bile reflux nor the concentrations of bile acids or lysolecithin in the gastric fluid differed significantly in the groups with different numbers of CLO in the gastric mucosa. Our results suggest that DGR, in the quantities commonly present in unoperated stomachs, does not effect the presence of C. pyloriin the gastric mucosa. 相似文献
10.
Mucosal melanoma of the upper airways tract mucosal melanoma: A systematic review with meta‐analyses of treatment 下载免费PDF全文