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排序方式: 共有171条查询结果,搜索用时 0 毫秒
1.
We studied follow-up iliac mucosa biopsies from 11 patients with juvenile polyposis and 4 patients with familial adenomatous polyposis who had undergone total colectomy with mucosal proctoectomy with creation of straight ileoanal anastomosis. The biopsies that have been taken from the posterior wall of the terminal ileum show incomplete and focal neocolonic transformation of iliac mucosa. Nevertheless, in most cases iliac mucosa preserved its architectural and histochemical characteristics. Chronic inflammation in iliac mucosa is not typical for patients with polyposis. 相似文献
2.
From 1989 to 1998 we treated 94 patients with pancreatic pseudocysts. 55 patients underwent laparotomy (external drainage of the cyst, sequestrectomy). 14.5% patients of this group presented with postoperative complications, mean hospital stay was 36 days. During 1997-1998 we performed US-controlled punctures and drainage in 37 patients with pancreatic pseudocysts. This method was efficient in 83.7% of the cases without sequesters in the cystic cavity. Use of this method allowed to decrease the percentage of complications and lethality rate, and reduce the mean hospital stay by 47.2%. 相似文献
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Novak K Polic S Capkun V Fabijanic D Lukin A Dujic Z Rumboldt Z 《Archives of gerontology and geriatrics》2012,54(1):266-270
Previous studies have shown a paradoxical increase in early mortality in older patients (>70 years) with acute STEMI treated with fibrinolytic therapy (FT), which has been attributed to the development of free wall rupture (FWR). Our aim was to assess occurrence of FWR in STEMI patients receiving FT. In this 7-year prospective study, data from 1701 consecutive patients were obtained. We analyzed predictors of the in-hospital mortality in patients > 70 years old. The independent contribution of several variables to overall mortality and FWR development was assessed using multiple logistic regression analyses. The mortality of entire cohort was 18% (306/1701). Diabetes mellitus, anterior infarction, smoking, female gender and hypercholesterolemia were independent predictors of in-hospital mortality. FT was given to 18% of all patients (304/1701) of which 13% died (39/304). FWR was 18.4-times more often in patients who received FT. Among patients younger than 70 years who received FT there was no FWR, while in patients ≥70 years of age FWR was found in almost half of the deceased (30/68; 44%). Application of FT in STEMI patients is not associated with higher mortality, but significantly increases number of FWR, especially in patients over 70 years of age. 相似文献
5.
Matthew Bohm Ronghui Xu Yiran Zhang Sashidhar Varma Monika Fischer Gursimran Kochhar Brigid Boland Siddharth Singh Robert Hirten Ryan Ungaro Eugenia Shmidt Karen Lasch Vipul Jairaith David Hudesman Shannon Chang Dana Lukin Arun Swaminath Bruce E. Sands Jean-Frederic Colombel Sunanda Kane Edward V. Loftus Jr Bo Shen Corey A. Siegel William J. Sandborn Parambir S. Dulai the VICTORY Collaboration 《Alimentary pharmacology & therapeutics》2020,52(4):669-681
6.
Valerii E. Orel Marina Tselepi Thanos Mitrelias Alexander Rykhalskyi Andriy Romanov Valerii B. Orel Anatoliy Shevchenko Anatoliy Burlaka Sergey Lukin Crispin H.W. Barnes 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(4):1249-1256
Modulation of reactive oxygen and nitrogen species in a tumor could be exploited for nanotherapeutic benefits. We investigate the antitumor effect in Walker-256 carcinosarcoma of magnetic nanodots composed of doxorubicin-loaded Fe3O4 nanoparticles combined with electromagnetic fields. Treatment using the magnetic nanodot with the largest hysteresis loop area (3402 erg/g) had the greatest antitumor effect with the minimum growth factor 0.49 ± 0.02 day–1 (compared to 0.58 ± 0.02 day–1 for conventional doxorubicin). Electron spin resonance spectra of Walker-256 carcinosarcoma treated with the nanodots, indicate an increase of 2.7 times of free iron (that promotes the formation of highly reactive oxygen species), using the nanodot with the largest hysteresis loop area, compared to conventional doxorubicin treatment as well as increases in ubisemiquinone, lactoferrin, NO-FeS-proteins. Hence, we provide evidence that the designed magnetic nanodots can modulate the tumor redox state. We discuss the implications of these results for cancer nanotherapy. 相似文献
7.
Glutathione synthesis is essential for mouse development but not for cell growth in culture 下载免费PDF全文
Shi ZZ Osei-Frimpong J Kala G Kala SV Barrios RJ Habib GM Lukin DJ Danney CM Matzuk MM Lieberman MW 《Proceedings of the National Academy of Sciences of the United States of America》2000,97(10):5101-5106
Glutathione (GSH) is a major source of reducing equivalents in mammalian cells. To examine the role of GSH synthesis in development and cell growth, we generated mice deficient in GSH by a targeted disruption of the heavy subunit of gamma-glutamylcysteine synthetase (gammaGCS-HS(tm1)), an essential enzyme in GSH synthesis. Embryos homozygous for gammaGCS-HS(tm1) fail to gastrulate, do not form mesoderm, develop distal apoptosis, and die before day 8.5. Lethality results from apoptotic cell death rather than reduced cell proliferation. We also isolated cell lines from homozygous mutant blastocysts in medium containing GSH. These cells also grow indefinitely in GSH-free medium supplemented with N-acetylcysteine and have undetectable levels of GSH; further, they show no changes in mitochondrial morphology as judged by electron microscopy. These data demonstrate that GSH is required for mammalian development but dispensable in cell culture and that the functions of GSH, not GSH itself, are essential for cell growth. 相似文献
8.
Diagnosis of Rickettsia prowazekii forms at the final stage of its elimination. 30 cases of petechial typhus occurred in Russian Federation during the period from 1973 to 1996 were subjected to retrospective analysis. On the base of this analysis the false registration of disease "epidemic" form was revealed. Indeed it appeared to be the recurrences, i.e. the Brill's disease. The authors propose to use the table of differential diagnostic signs of both forms of Rickettsia prowazekii based on their clinical-and-epidemiological special features. It will help to avoid the false reports. 相似文献
9.
11 patients with juvenile polyposis and 4 patients with familial adenomatous polyposis after total colectomy entered the study. Long-term follow-up with endoscopic examination and multiple biopsies in these patients showed high probability of polyps in preserved regions of the gastrointestinal tract. Therefore, regular prophylactic endoscopy, morphological examinations and biopsies of endoscopically normal mucous membrane are justified. Such policy is recommended especially for patients with familial adenomatous polyposis. 相似文献
10.