全文获取类型
收费全文 | 8301篇 |
免费 | 406篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 143篇 |
儿科学 | 132篇 |
妇产科学 | 85篇 |
基础医学 | 1145篇 |
口腔科学 | 199篇 |
临床医学 | 508篇 |
内科学 | 2133篇 |
皮肤病学 | 84篇 |
神经病学 | 673篇 |
特种医学 | 358篇 |
外科学 | 1192篇 |
综合类 | 30篇 |
预防医学 | 220篇 |
眼科学 | 261篇 |
药学 | 701篇 |
中国医学 | 14篇 |
肿瘤学 | 861篇 |
出版年
2023年 | 46篇 |
2022年 | 73篇 |
2021年 | 135篇 |
2020年 | 81篇 |
2019年 | 106篇 |
2018年 | 119篇 |
2017年 | 83篇 |
2016年 | 138篇 |
2015年 | 141篇 |
2014年 | 186篇 |
2013年 | 210篇 |
2012年 | 327篇 |
2011年 | 346篇 |
2010年 | 248篇 |
2009年 | 205篇 |
2008年 | 384篇 |
2007年 | 382篇 |
2006年 | 376篇 |
2005年 | 408篇 |
2004年 | 406篇 |
2003年 | 405篇 |
2002年 | 392篇 |
2001年 | 328篇 |
2000年 | 309篇 |
1999年 | 267篇 |
1998年 | 113篇 |
1997年 | 80篇 |
1996年 | 77篇 |
1995年 | 70篇 |
1994年 | 61篇 |
1993年 | 46篇 |
1992年 | 208篇 |
1991年 | 167篇 |
1990年 | 176篇 |
1989年 | 164篇 |
1988年 | 163篇 |
1987年 | 152篇 |
1986年 | 136篇 |
1985年 | 111篇 |
1984年 | 99篇 |
1983年 | 74篇 |
1982年 | 44篇 |
1981年 | 44篇 |
1979年 | 75篇 |
1978年 | 55篇 |
1976年 | 44篇 |
1972年 | 44篇 |
1971年 | 41篇 |
1970年 | 42篇 |
1968年 | 45篇 |
排序方式: 共有8739条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
7.
Kiyotaka YOH Makoto TAHARA Kenji KAWADA Hirofumi MUKAI Masanobu NAKATA Kuniaki ITOH Mitsuhiko KAWASHIMA Hideki NISHIMURA Ryuichi HAYASHI Takashi OGINO Hironobu MINAMI 《Asia-Pacific Journal of Clinical Oncology》2006,2(4):180-184
Background: Olfactory neuroblastoma is a rare sino‐nasal tumor arising from the olfactory epithelium and is often characterized by local invasion or metastasis. The role of chemotherapy in the treatment of this tumor is unclear. The purpose of this study was to review our institution’s experience of chemotherapy for advanced or recurrent olfactory neuroblastoma. Methods: Twenty‐one patients with histologically proven olfactory neuroblastoma were treated at our institution between 1992 and 2002. Twelve of these patients received chemotherapy in the setting of unresectable or recurrent disease and were retrospectively reviewed for clinical characteristics, treatment outcome or survival. Results: Eight patients of the 12 patients received cisplatin‐based chemotherapy and the remaining four patients received chemotherapy consisting of docetaxel plus irinotecan (three patients) or cyclophosphamide, doxorubicin, and vincristine (1 patient). A partial response was achieved in five patients, with an overall response rate of 42%, although the chemotherapeutic regimens were heterogeneous. Two partial responses were obtained among the three patients who received docetaxel plus irinotecan. The response rate to chemotherapy was 83% in the younger age group (<40 years), as opposed to 0% in the older age group (≥40 years), and the difference between the two groups was statistically significant (P = 0.02). Conclusion: Our study indicated that olfactory neuroblastoma would be sensitive to chemotherapy, especially with young patients. Docetaxel plus irinotecan has the possibility of showing favorable response, and warrants further investigation. 相似文献
8.
9.
Mitsumasa Iwata Shunji Izuta Motoshi Suzuki Kiyohide Kojima Yoshihito Furuhashi Yutaka Tomoda Shonen Yoshida 《Cancer science》1991,82(4):433-439
We examined the mechanisms of the inhibition of DNA synthesis by a new platinum compound, (-)-( R )-2-aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)-2-platinum(II) monohydrate (DWA-2114R), a derivative of the antitumor drug cis- diamminedichloroplatinum(II) (CDDP), using prokaryotic and eukaryotic DNA polymerases. Preincubating activated DNA with CDDP or DWA-2114R reduced its template activity for prokaryotic and eukaryotic DNA polymerases in a dose-dependent manner. DWA2114R required six times greater drug concentration and two times longer incubation time to show the same decrease of the template activity compared to CDDP. Treatment of primed pUC118 ssDNA templates with the two drugs followed by second-strand synthesis by prokaryotic and eukaryotic DNA polymerases revealed that DWA2114R bound to DNA in a similar manner to CDDP and these adducts blocked DNA elongation by DNA polymerases of eukaryotes as well as of prokaryotes. With these two drugs, the elongations by E. coli DNA polymerase I (Klenow fragment), T7 DNA polymerase and calf thymus DNA polymerase α were strongly arrested at guanine-guanine sequences (GG). Stop bands were also observed at adenine-guanine sequences (AG) guanine-adenine-guanine sequences (GAG) and mono-guanine sequence (G). Calf testis DNA polymerase β was also arrested efficiently at AG, GAG and G, but much more weakly at GG. This pattern was common to DWA2114R and CDDP. 相似文献
10.
Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats 总被引:1,自引:0,他引:1
Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384) on learning and memory were studied using four different experimental rat models. In electroconvulsive shock- or scopolamine-induced amnesia in the step-through passive avoidance task, DM-9384 improved both types of amnesia when administered before the training trial. Aniracetam also showed similar but somewhat weaker effects. Furthermore, in the scopolamine amnesia model, an improvement was confirmed with arecoline. The dose-response curves for these compounds were bell-shaped. In the shuttle box active avoidance task, DM-9384 administered daily 1 hr before each training session facilitated the acquisition process of the avoidance response. In addition, the experiment of light-dark discrimination task with positive reinforcement showed that this compound administered daily after each session slightly accelerated the acquisition process of the correct response. These results suggest an ability of DM-9384 to enhance cognitive functions. 相似文献