全文获取类型
收费全文 | 684篇 |
免费 | 14篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 12篇 |
妇产科学 | 47篇 |
基础医学 | 56篇 |
口腔科学 | 3篇 |
临床医学 | 54篇 |
内科学 | 269篇 |
皮肤病学 | 3篇 |
神经病学 | 34篇 |
特种医学 | 25篇 |
外科学 | 100篇 |
综合类 | 1篇 |
预防医学 | 14篇 |
眼科学 | 1篇 |
药学 | 36篇 |
肿瘤学 | 45篇 |
出版年
2021年 | 5篇 |
2019年 | 4篇 |
2018年 | 2篇 |
2016年 | 11篇 |
2015年 | 8篇 |
2014年 | 11篇 |
2013年 | 8篇 |
2012年 | 31篇 |
2011年 | 48篇 |
2010年 | 29篇 |
2009年 | 20篇 |
2008年 | 31篇 |
2007年 | 45篇 |
2006年 | 38篇 |
2005年 | 38篇 |
2004年 | 45篇 |
2003年 | 37篇 |
2002年 | 30篇 |
2001年 | 37篇 |
2000年 | 15篇 |
1999年 | 33篇 |
1998年 | 10篇 |
1997年 | 9篇 |
1996年 | 7篇 |
1995年 | 3篇 |
1994年 | 12篇 |
1993年 | 10篇 |
1992年 | 22篇 |
1991年 | 19篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 10篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1976年 | 1篇 |
1975年 | 3篇 |
1968年 | 1篇 |
1957年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有700条查询结果,搜索用时 15 毫秒
1.
2.
N Mihara T Hachisuga S Yamasaki K Fukuda G Iwasaka H Sugimori S Miyahara 《Gan no rinsho》1987,33(15):1939-1944
A rare case of malignant peritoneal mesothelioma in a 49-year-old Japanese woman is presented. The tumor was limited to the peritoneum, and was cytologically and histologically identified as being composed of two components, epithelial and non-epithelial forms. The transition in her CA-125 level suggested that this tumor had good prospects of developing into a malignant mesothelioma. The good prognosis of the patient is considered to be attributed to detecting this tumor in its early stage and to aggressive chemotherapy. 相似文献
3.
H Iwasaka T Kitano A Mizutani S Yoshitake S Hoashi T Noguchi K Taniguchi N Honda 《Masui. The Japanese journal of anesthesiology》1992,41(11):1719-1722
Thrombin-antithrombin III complex (TAT) and plasminogen activator inhibitor (PAI) were measured during liver resection surgery in 8 patients. TAT and PAI activities of patients under liver resection were compared with those of 11 patients under resection of esophageal carcinoma. TAT activity increased during liver resection (P < 0.001) and reached 14 times (P < 0.001) of its control value in the recovery room. PAI activity was very stable during operation, but increased to twice (P < 0.01) of its control value in the recovery room. TAT activity of patients after liver surgery in the recovery room was (P < 0.05) more than twice of that of patients after esophageal surgery. We conclude that hypercoagulable state occurred during liver resection to a greater degree compared with that observed with esophageal surgery, and that its cause might be liver resection itself. 相似文献
4.
Toshiji Ishiwata Ryo Koyama Noriyuki Homma Mitsuhiro Fujii Naoko Iwakami Yuta Nakao Shin-ichiro Iwakami Kazuhisa Takahashi 《Nihon Kokyūki Gakkai zasshi》2006,44(10):749-753
A 28-year-old man complaining of myiodesopsia was given a diagnosis of uveitis. Subsequently he complained facial nerve palsy and enlargement of parotid gland. Heerfordt's syndrome was diagnosed based on the results of several examinations. Facial nerve palsy, enlargement of the parotid gland and uveitis were improved by systemic corticosteroid therapy. At present he is receiving systemic corticosteroid therapy, but numbness in the mouth, thought to be the involvement of the trigeminal nerve, remains. Systemic corticosteroid therapy is usually effective for most cases with Heerford's syndrome. On the other hand, there are some cases with the prolonged peripheral nerve involvement despite systemic corticosteroid therapy, as seen in this case. If peripheral nerve involvement is prolonged, it is necessary to consider small-fibre neuropathy as one possible cause. 相似文献
5.
H Taniguchi T Iwasaka Y Takayama H Takashima T Tamura S Kitashiro T Sugiura M Inada 《Journal of cardiology》1992,22(4):591-594
To elucidate the clinical characteristics of pulmonary edema in unstable angina, 120 patients with unstable angina who admitted to the hospital within 6 hours after the onset of chest pain were studied. The criteria for the diagnosis of pulmonary edema included interstitial pulmonary edema and diffuse alveolar edema. Pulmonary edema was present in 24 patients. In these patients, the duration of chest pain was relatively longer, and the incidences of diabetes mellitus, emergency coronary revascularization and multiple-vessel coronary artery disease were higher than in those without pulmonary edema. In addition, in-hospital mortality rate in patients with pulmonary edema was higher than in those without it (21 vs 1%, p < 0.001), which is probably due to a large area of myocardial ischemia. For these patients, therefore, early diagnosis and appropriate therapy to save viable segments of the myocardium are mandatory. 相似文献
6.
Fibrate for treatment of primary biliary cirrhosis 总被引:1,自引:0,他引:1
Shinji Iwasaki Naoaki Akisawa Toshiji Saibara Saburo Onishi 《Hepatology research》2007,37(S3):S515-S517
Recent studies of the effectiveness of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cirrhosis (PBC) reported that UDCA therapy did not necessarily stop the progression of liver fibrosis in all patients, even those with early stage PBC. Thus, there is a need for more effective treatments that could prevent asymptomatic PBC from progressing to the icteric stage. Bezafibrate is effective in approximately two-thirds of non-icteric patients who have not shown a complete response to UDCA. Serum bilirubin, aspartate aminotransferase and γ-guanosine 5'-triphosphate levelswere significantly lower in patients who responded to additional bezafibrate on univariate analysis. The putative mechanism by which bezafibrate acts in cholestasis is by increasing phospholipid output into bile, which forms micelles with the hydrophobic bile acid that reduces its toxicity. 相似文献
7.
Dr. S. Ichioka M. Iwasaka M. Shibata K. Harii A. Kamiya S. Ueno 《Medical & biological engineering & computing》1998,36(1):91-95
There have been few studies of the effect of static magnetic fields on microcirculatory haemodynamics in vivo. The rat skinfold
transparent chamber technique was used, which provides an excellent means of observing and quantifying direct in vivo microvascular
haemodynamic responses to static magnetic fields up to 8 T. An intravital videomicroscope was used to measure the changes
in blood flow before and after exposure to a magnetic field for 20 min in a horizontal type superconducting magnet with a
bore 100 mm in diameter and 700 mm long. After exposure, microcirculatory blood flow showed an initial increase for about
5 min followed by a gradual decrease and a return to the control value. It is hypothesised that these changes represent rebound
hyperaemia following reduced blood flow during exposure. 相似文献
8.
Early detection of the no-reflow phenomenon in reperfused acute myocardial infarction using technetium-99m tetrofosmin imaging 总被引:1,自引:0,他引:1
Hamada S Nakamura S Sugiura T Murakami T Fujimoto T Watanabe J Baden M Hatada K Iwasaka T 《European journal of nuclear medicine》1999,26(3):208-214
Evaluation of myocardial perfusion in the early stage of acute myocardial infarction (MI) is clinically important for adjunctive therapies to minimize infarct size. To determine the role of early scintigraphic detection of impaired myocardial reperfusion after primary coronary angioplasty (PTCA) in patients with acute MI, semiquantitative technetium-99m tetrofosmin single-photon emission tomographic (SPET) imaging was performed before primary PTCA (before; area at risk), 60 min after PTCA (after) and at 1 month (1 M; final infarct) in 35 patients with acute MI. The left ventricle was divided into 13 segments and the defect score was calculated as the sum of the perfusion defect of each segment, from 3 (complete defect) to 0 (normal perfusion). A significant myocardial perfusion change after PTCA was defined as a change in the defect score (before minus after PTCA) of >/=4. The echocardiographic asynergic score was defined as the number of asynergic (severe hypokinetic or akinetic) segments corresponding to the analogous segments on SPET images, and recovery of wall motion was calculated as absolute change in the asynergic score (before PTCA minus 1 M). Among the 35 patients, 15 (43%) had a change in the defect score of <4 (no reflow: group 1) while 20 had a change in the defect score of >/=4 (reflow: group 2). There were no significant differences between the two groups with respect to the time between admission to PTCA, revascularization time, collateral grade or Thrombolysis in Myocardial Infarction (TIMI) flow grade before PTCA. Despite the lack of a difference in area at risk between the two groups (group 1 = 12.8+/-4.3 and group 2 = 15.1+/-4.7), final infarct size in group 1 was significantly larger compared with that in group 2 (8.1+/-4.3 vs 4.9+/-3.0, P<0.001). Recovery of wall motion was significantly smaller in group 1 than in group 2 (4.3+/-1.7 to 3.5+/-1.5 vs 4. 1+/-2.1 to 1.6+/-1.6, P<0.001). In conclusion, a small change (<4) in defect score (scintigraphic no-reflow phenomenon) after primary PTCA indicates persisting impaired myocardial perfusion or irreversible cellular damage just after PTCA which is associated with poor recovery of wall motion, as compared with that observed in cases of reflow (>/=4 in defect score). 相似文献
9.
Long-term administration of atrial natriuretic peptide in patients with acute heart failure. 总被引:4,自引:0,他引:4
S Kitashiro T Sugiura Y Takayama Y Tsuka T Izuoka S Tokunaga T Iwasaka 《Journal of cardiovascular pharmacology》1999,33(6):948-952
A short-term treatment of atrial natriuretic peptide (ANP), a circulating hormone of cardiac origin, is reported to improve cardiac performance in patients with chronic heart failure. However, clinical usefulness of long-term administration of ANP in patients with congestive heart failure has not been reported. We studied 36 patients with severe acute heart failure who resisted various therapy. Hemodynamic parameters were measured before and 48 h after initiating ANP infusion (n = 18) or normal saline (n = 18). Mean pulmonary capillary wedge pressure (23-->13 mm Hg), mean right atrial pressure (10-->5 mm Hg), systemic vascular resistance (2,169-->1,307 dyn x s x cm(-5)) and pulmonary vascular resistance (318-->136 dyn x s x cm(-5)) decreased significantly, whereas cardiac index (1.9-->2.6 L/min/m2) and urine volume (1,692-->2,560 ml/day) increased during long-term ANP infusion (before-->48 h). Moreover, in eight patients with long-term ANP infusion, these hemodynamic effects were maintained at 7 days after initiating ANP infusion. Vasodilating, pulmonary vasorelaxant, and diuretic activities of ANP are maintained without tolerance, and thus long-term ANP infusion is clinically useful in patients with severe acute heart failure. 相似文献
10.
Hideo Iwasaka Kouji Itoh Hiroshi Miyakawa Takaaki Kitano Kazuo Taniguchi Natsuo Honda 《Journal canadien d'anesthésie》1996,43(10):1059-1061