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1.
Current trend in the treatment of Hodgkin's disease 总被引:1,自引:0,他引:1
M Tubiana J L Amiel M Hayat M Henry-Amar J M Cosset J P Droz P Carde 《Radiation Medicine》1983,1(3):221-229
The analysis of three subsequent randomized trials carried out within the frame of the European Organization for Research on Cancer (E.O.R.T.C.) enables to define a strategy for the staging and the treatment of early stages of Hodgkin's disease. Several prognostic factors were identified by multivariate analyses: 1) erythrocyte sedimentation rate, which has a greater impact on relapse-free survival than systemic symptoms but which can be combined with them; the combination of the two is a more powerful prognostic indicator than ESR alone; 2) the number of involved lymphatic areas: patients with one or two lymphatic areas involved (CS I and II2) have a better outcome than stage II patients with 3 or more areas involved (CS II3). Patients with favorable prognostic indicators are submitted to staging laparotomy because for them spleen involvement has a pejorative impact. For patients with unfavorable indicators, the spleen involvement has little prognostic significance and therefore those patients who need, anyway, an aggressive treatment do not undergo staging laparotomy. Patients with favorable prognostic indicators and negative staging laparotomy can be treated by radiotherapy alone, patients with positive laparotomy or patients with unfavorable prognostic indicators are treated by combination of multiple chemotherapy and radiotherapy. 相似文献
2.
P. Hayat 《Phytothérapie》2006,4(5):217-219
Sans résumé
Communication présentée lors de la journée AMPP : Cancer et maladies graves, juin 2005. 相似文献
3.
Hayat GR Kulkantrakorn K Campbell WW Giuliani MJ 《Journal of the neurological sciences》2000,181(1-2):38-43
BACKGROUND: Neuromyotonia (NMT) has been postulated to be an autoimmune channelopathy, probably by affecting voltage gated potassium channels (VGKC) leading to excitation and abnormal discharges [Sinha et al., Lancet 338 (1991) 75]. OBJECTIVE: To report three patients with NMT who had other associated immune-mediated conditions, i.e., myasthenia gravis, thymoma and various types of peripheral neuropathies. One patient had peripheral neuropathy and involvement of pre- and post-synaptic neuromuscular junction. RESULTS: All three patients had evidence of polyneuropathy and neuromyotonic discharges on electrodiagnostic studies. Elevated acetylcholine receptor antibodies were noted in all patients and malignant thymoma was found in two patients with metastasis. All three patients showed moderate to marked response to plasma exchange. CONCLUSIONS: These findings strongly suggest a humoral autoimmune pathogenesis of NMT, probably by K(+) channel involvement, affecting acetylcholine quantal release and postsynaptic membrane. Clinicians should be aware of this association of immune-mediated conditions in NMT patients and marked improvement with plasma exchange. 相似文献
4.
Sehrish Bilal Muhammad Nasir M. Mudassir Hassan Muhammad Fayyaz ur Rehman Amtul Jamil Sami Akhtar Hayat 《RSC advances》2022,12(26):16860
Herein, an electrochemical biosensor has been prepared to assess the sensitivity of an organophosphate insecticide, malathion, to acetylcholinesterase (AChE) enzyme of three insects including Apis mellifera (honeybee), Tribolium castaneum (red flour beetle), and Zootermopsis nevadensis (dampwood termite). A composite of nickel chromite (NiCr2O4) and graphitic carbon nitride (g-C3N4) was prepared and characterized for its morphological, chemical and electrical properties. The NiCr2O4/g-C3N4 composite integrated pencil graphite electrodes were used to covalently immobilize insect AChE enzymes and amperometric response of bioelectrodes was determined through cyclic voltammetry. The prepared bioelectrodes exhibited high enzyme immobilization efficiency and electro-catalytic performance. The integrated bioelectrodes could efficiently detect malathion induced inhibition of insects'' AChEs. The linear ranges for malathion were found to be 0.1–1.6 μM, 1–40 nM and 2–100 nM, and LODs were 2 nM, 0.86 nM and 2.3 nM for A. mellifera, T. castaneum, and Z. nevadensis, respectively. Additionally, the biosensing platform developed using A. mellifera AChE was found highly sensitive and effective for malathion recoveries from spiked wheat flour samples with high recovery rates. Moreover, the proposed method was adequately reproducible and selective. The results revealed that A. mellifera AChE is less sensitive to inhibition by malathion as compared to T. castaneum, and Z. nevadensis AChE. The experimental results were validated through computational docking of malathion with insect AChEs and the results were in correspondence to experimental outcomes. The proposed method can be a plausible alternate to conventional analytical methods to assess the pesticide sensitivity and toxicity of various compounds against insect enzymes.An innovative electrochemical assay has been established to determine pesticide sensitivity against acetylcholinesterase and possible toxicity against insects. The analytical efficiency of three common insect AChEs was determined through this method. 相似文献
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6.
Diabetic peripheral neuropathy in people with type 2 diabetes is poorly managed because of its insidious onset, delayed diagnosis and more complex aetiology resulting from the contribution of not only hyperglycaemia, but also ageing, hyperlipidaemia, hypertension and obesity. Because there is no US Food and Drug Adminstration-approved disease-modifying therapy for diabetic peripheral neuropathy, the key to ameliorating it in type 2 diabetes has to be through earlier diagnosis and timely multi-factorial risk factor reduction. The management of painful diabetic peripheral neuropathy also requires a detailed appraisal of the choice of therapy, taking into account efficacy, patient wishes, comorbidities, side effect profile and potential for abuse. 相似文献
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8.
Hayat Mousa Rodrigo Machado Marina Orsi Catherine S. Chao Tala Alhajj Mark Alhajj Courtney Port Beth Skaggs Frederick W. Woodley 《Current gastroenterology reports》2014,16(8):1-8
Pancreatic cancer is the fourth leading cause of cancer deaths in the USA. Although some patients will present with premalignant pancreatic lesions (i.e., intraductal papillary mucinous neoplasms) or localized tumors amenable to curative resection, the majority of patients will unfortunately present with technically unresectable or metastatic disease. This review of the recent medical literature will discuss the optimal work-up and management of premalignant pancreatic lesions and the surgical management of localized, borderline resectable, and locally advanced (i.e., unresectable) pancreatic tumors. It will focus on new criteria used to define surgical “resectability,” the significance and clinical impact of surgical margins, the role of multimodality therapy in the management of patients with borderline resectable or locally advanced tumors, the role of surgery for local or distant recurrence, and minimally invasive surgical approaches. 相似文献
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10.
Priya Palta G. Page R. L. Piferi J. M. Gill M. J. Hayat A. B. Connolly S. L. Szanton 《Journal of urban health》2012,89(2):308-316
Hypertension affects a large proportion of urban African-American older adults. While there have been great strides in drug
development, many older adults do not have access to such medicines or do not take them. Mindfulness-based stress reduction
(MBSR) has been shown to decrease blood pressure in some populations. This has not been tested in low-income, urban African-American
older adults. Therefore, the primary purpose of this pilot study was to test the feasibility and acceptability of a mindfulness-based
program for low income, minority older adults provided in residence. The secondary purpose was to learn if the mindfulness-based
program produced differences in blood pressure between the intervention and control groups. Participants were at least 62 years
old and residents of a low-income senior residence. All participants were African-American, and one was male. Twenty participants
were randomized to the mindfulness-based intervention or a social support control group of the same duration and dose. Blood
pressure was measured with the Omron automatic blood pressure machine at baseline and at the end of the 8-week intervention.
A multivariate regression analysis was performed on the difference in scores between baseline and post-intervention blood
pressure measurements, controlling for age, education, smoking status, and anti-hypertensive medication use. Effect sizes
were calculated to quantify the magnitude of the relationship between participation in the mindfulness-based intervention
and the outcome variable, blood pressure. Attendance remained >80% in all 8 weeks of both the intervention and the control
groups. The average systolic blood pressure decreased for both groups post-intervention. Individuals in the intervention group
exhibited a 21.92-mmHg lower systolic blood pressure compared to the social support control group post-intervention and this
value was statistically significant (p = 0.020). The average diastolic blood pressure decreased in the intervention group post-intervention, but increased in the
social support group. Individuals in the intervention group exhibited a 16.70-mmHg lower diastolic blood pressure compared
to the social support group post-intervention, and this value was statistically significant (p = 0.003). Older adults are at a time in life when a reflective, stationary intervention, delivered in residence, could be
an appealing mechanism to improve blood pressure. Given our preliminary results, larger trials in this hypertensive study
population are warranted. 相似文献