全文获取类型
收费全文 | 707篇 |
免费 | 49篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 25篇 |
妇产科学 | 18篇 |
基础医学 | 111篇 |
口腔科学 | 10篇 |
临床医学 | 67篇 |
内科学 | 159篇 |
皮肤病学 | 6篇 |
神经病学 | 58篇 |
特种医学 | 25篇 |
外科学 | 113篇 |
综合类 | 6篇 |
一般理论 | 1篇 |
预防医学 | 55篇 |
药学 | 51篇 |
肿瘤学 | 50篇 |
出版年
2023年 | 4篇 |
2022年 | 8篇 |
2021年 | 22篇 |
2020年 | 6篇 |
2019年 | 12篇 |
2018年 | 16篇 |
2017年 | 12篇 |
2016年 | 5篇 |
2015年 | 9篇 |
2014年 | 12篇 |
2013年 | 41篇 |
2012年 | 52篇 |
2011年 | 69篇 |
2010年 | 24篇 |
2009年 | 21篇 |
2008年 | 44篇 |
2007年 | 37篇 |
2006年 | 33篇 |
2005年 | 40篇 |
2004年 | 49篇 |
2003年 | 35篇 |
2002年 | 29篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 5篇 |
1998年 | 10篇 |
1997年 | 3篇 |
1996年 | 9篇 |
1995年 | 12篇 |
1994年 | 9篇 |
1992年 | 4篇 |
1990年 | 4篇 |
1989年 | 9篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 8篇 |
1983年 | 3篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1969年 | 3篇 |
1966年 | 5篇 |
1965年 | 3篇 |
1929年 | 2篇 |
排序方式: 共有761条查询结果,搜索用时 15 毫秒
1.
B. A. Johnson Donald R. Jasinski Gantt P. Galloway Henry Kranzler Robert Weinreib Raymond F. Anton Barbara J. Mason Michael J. Bohn Helen M. Pettinati Richard Rawson Christopher Clyde 《Psychopharmacology》1996,128(2):206-215
Four hundred and twenty-three alcohol dependent subjects were enrolled into a 12-week randomized, double-blind, placebo-controlled
study to determine the safety and efficacy of the 5-HT2 receptor antagonist, ritanserin (2.5 mg/day or 5 mg/day), in reducing alcohol intake and craving. All subjects received 1
week of single-blind placebo prior to randomization into the 11-week double-blind phase. Additionally, all subjects received
weekly individual sessions of manual-guided cognitive-behavioral therapy. Comparing the single-blind period with endpoint,
there was approximately a 23% reduction in drinks/day; 34% fall in the total number of drinking days/week; 22% decrease in
drinks/drinking day; and a 37% diminution in alcohol craving for all treatment groups. All treatment groups experienced a
beneficial clinical outcome as assessed by the Clinical Global Impression Scale. There was, however, no significant difference
between treatment groups on any of these measures of alcohol drinking, craving, or clinical outcome. Subjects were of relatively
high social functioning at baseline, and this did not change significantly during treatment. Treatment groups did not differ
significantly on either medication compliance or reported adverse events. Ritanserin treatment was associated with a dose-related
prolongation of subjects’ QTc interval recording on the electrocardiogram. These results suggest that alcohol dependent subjects
can show marked clinical improvement within a structured alcohol treatment program. These findings do not support an important
role for ritanserin in the treatment of alcohol dependence.
Received: 30 April 1996/Final version: 3 July 1996 相似文献
2.
Soren P. Lund Leif Simonsen Adolf S. Fries 《Basic & clinical pharmacology & toxicology》1995,76(1):36-40
Abstract: The effects of repeated exposure to 20 p.p.m. 4-tert-butyltoIuene (CAS No. [98-51-1]) 6 hr/day for 14 days on the function of the intact nervous system were examined by measurements of flash evoked potentials in Wistar rats. The exposure to 4-tert-butyltoluene induced changes in the amplitudes of the flash evoked potentials. The changes were significantly different from controls on day 2, 19 and 26 after cessation of the exposure, but not on day 5 and 12. No significant difference in body weight gain between groups was found during the experiment. These results indicate that repeated exposure to 20 p.p.m. 4-tert-butyltoluene causes persistent changes in the function of the central nervous system measured as changes in the flash evoked potential. A reevaluation of the present TLV-value of 10 p.p.m. for 4-tert-butyltoluene is suggested. 相似文献
3.
Close pathogenetic and morphologic relationships exist between the alterations of the lumbosacral spine designated as spondylolysis, spondylolisthesis and praespondylolisthesis. The initial management of 105 patients with such conditions was conservative. However, of this group 34 patients with persistent instability and/or intractable neurologic symptoms were subsequently treated surgically, and the majority of them obtained lasting benefits. 相似文献
4.
The results of a modified Wilson shaft osteotomy for hallux valgus in 77 feet of 51 patients were excellent or good in 62 feet after 2 to 4 years. The correction of the hallux valgus angle and intermetatarsal angle was excellent or good in 69 feet. The operation is technically simple provided dorsal angulation of the distal fragment is avoided in the early postoperative period.A 相似文献
5.
6.
Schmid KW Bankfalvi A Mucke S Ofner D Riehemann K Schroder S Stucker A Totsch M Dockhorn-Dworniczak B 《Endocrine pathology》1996,7(2):121-130
Routinely processed tissues from a series of benign and malignant thyroid lesions were immunohistochemically investigated
with antibodies against p53 and mdm-2. p53 was immunolocalized in <10% of nuclei in 2/80 nodular goiters, 2/60 follicular
adenomas, 26/68 follicular carcinomas, 7/40 papillary carcinomas, 3/10 “insular” carcinomas, and 10/31 anaplastic carcinomas.
More than 10% positively stained nuclei were found in 2 widely invasive follicular, 2 insular, and 15 anaplastic carcinomas.
All p53-positive cases showed a concomitant immunohistochemical mdm-2 expression; an immunohistochemical colocalization on
serial section was demonstrated in 12 anaplastic carcinomas. Screening by polymerase chain reaction single-strand conformation
polymorphism (PCR-SSCP) analysis of these 12 cases revealed no relevant mutations in the coding regions of exons 2–11 of the
p53 gene. Additionally, 1 follicular adenoma, 6 follicular carcinomas (4 minimally and 2 widely invasive), 1 papillary, and
2 poorly differentiated insular carcinomas were mdm-2 positive without immunohistochemically detectable p53 expression. These
results provide evidence that wild-type p53 expression in thyroid carcinomas may be associated with mdm-2 induced formation
of stable complexes. However, the role of p53 mutations and p53 protein inactivation owing to other factors (e.g., mdm-2)
in the progression of thyroid carcinomas is still poorly understood. 相似文献
7.
A surface graft polymer with one or two phosphorylcholine (PC) polarheads at the terminus of the growing chain end was prepared by sequential reactions on a glass substrate. The dithiocarbamate group covalently bound to glass surfaces was derivatized with one or two PC groups and then irradiated with ultraviolet light in the presence of N,N-dimethylacrylamide (DMAAm). X-ray photoelectron spectroscopy, wettability measurements and dye staining experiment for the PC group showed that the resultant graft copolymers were produced via iniferter-based quasi-living radical polymerization, in which the polyDMAAm graft chain contains one or two PC groups at the terminal end of the graft chain. These polymer surface grafts may help provide biocompatibility. 相似文献
8.
Forsyth MA Parida S Alexandersen S Belsham GJ Barrett T 《Journal of virological methods》2003,107(1):29-36
An RT-PCR/ELISA system has been developed that detects and differentiates Rinderpest virus (RPV) from the other closely related morbillivirus of ruminants, Peste des petits Ruminants virus (PPRV). In addition, using lineage specific probes, it is possible to determine whether the virus sample is wild-type or vaccine, and the likely origin of the outbreak if it is wild-type. It involves carrying out a RT-PCR with one digoxygenin (Dig)-labelled primer followed by a hybridisation step with a virus-specific, biotin-labelled, probe. The hybridisation step is carried out in an ELISA format on a streptavidin-coated plate. The DIG-labelled products are detected using a specific anti-DIG monoclonal antibody and an anti-mouse horseradish peroxidase conjugate. The hybridisation step replaces nucleotide sequencing or nested PCR for confirmation of the identity of DNA product. The assay is fast and easy to carry out and can give semi-quantitative estimates of the virus content of samples. 相似文献
9.
Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI 总被引:1,自引:0,他引:1
Choe R Corlu A Lee K Durduran T Konecky SD Grosicka-Koptyra M Arridge SR Czerniecki BJ Fraker DL DeMichele A Chance B Rosen MA Yodh AG 《Medical physics》2005,32(4):1128-1139
We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy. 相似文献
10.
Although hemagglutination by Staphylococcus aureus has been associated with the pathogenesis of bovine mastitis, this trait has not been characterized with regard to human disease. In this study, the prevalence of hemagglutination in 100 strains of S. aureus responsible for bovine mastitis or human bacteremia, was characterized. Under optimum conditions hemagglutination was noted in 23% of the bovine strains, but only 13% of human strains, leading us to conclude that this trait is not a significant virulence determinant in human systemic infection. Additional studies indicate the hemagglutinin of S. aureus strains responsible for human bacteremia is proteinaceous in character. 相似文献