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高血压性心脏病抗G-蛋白偶联β_1-肾上腺素能受体与M_2-胆碱能受体自身抗体的初步研究 总被引:3,自引:0,他引:3
目的抗心肌β1和M2的自身抗体是否与高血压性心脏病有关。方法以心脏G-蛋白偶联受体β1和M2细胞外第二环表位肽段的合成肽作为抗原,应用酶联免疫吸附测定(ELISA)技术检测44例高血压性心脏病(HCD)患者、36例单纯性高血压患者和41例正常人(对照组)血清中抗β1和M2受体的自身抗体。结果抗心肌β1受体自身抗体的检出率,高血压性心脏病患者为47.7%(22/44),显著高于高血压患者11.1%(4/36)与正常人12.1(5/41);抗心肌M2受体自身抗体的检出率,高血压性心脏病患者为45.5%(20/44),显著高于高血压患者8.3%(3/36)与正常人9.8%(4/36)。高血压性心脏病患者血清中抗β1和M2受体的自身抗体滴度分别为1∶96与1∶103,远高于单纯性高血压和对照组的1∶40与1∶24的相应抗体滴度(P<0.05)。结论高血压性心脏病患者不仅存在抗心肌β1和M2受体的自身抗体而且其抗体滴度也明显高于单纯性高血压及正常人,检测该抗体对预测原发性高血压患者是否并发心肌病变,可能有一定的参考价值。 相似文献
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It is well established that genetic and environmental factors are involved in the etiology of essential hypertension(EH), previous studies have suggested that at least one of the HLA genes is responsihle for the genetic susceptlbility to EH. Our aim in the present study was to investigate this issue in China by the PCR-SSP HLA-DRB1 typing method. The resuks showed an increased frequency of HLA-DR2 and a decreased frequency of HLA-DR7 with EH patients compared with controls. We consider that HLA-DR2 may represent a marker for susceptibility to EH in the North Chinese popuhtlon. 相似文献
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