自然疗法 降压良药

在最近一次国际心血管病学术会议上,有关专家研究报告指出,高血压病有一半以上的患者实际上可以完全不需要药物的帮助,只需运用自然疗法,就可得以完全自愈。专家们说:在高血压队伍中,大多数人的血压并不特别高,而且也没有重要脏器的损害,他们完全可以通过调整饮食、平衡心理、戒烟戒酒和体育运动等自然疗法来使血压恢复正常。     

Lower Phosphorylation of p38 MAPK Blocks the Oxidative Stress-induced Senescence in Myeloid Leukemic CD34~+CD38~- Cells

Leukemia seems to depend on a small population of "leukemia stem cells (LSCs)" for its growth and metastasis. However, the precise surviving mechanisms of LSCs remain obscure. Cellular senescence is an important obstacle for production and surviving of tumor cells. In this study we investigated the activated state of a pathway, in which reactive oxygen species (ROS) induces cellular senescence through DNA damage and phophorylation of p38 MAPK (p38), in myeloid leukemic CD34+CD38- cells. Bone marrow samples were obtained from patients with acute myeloid leukemia (AML, n=11) and chronic myeloid leukemia (CML, n=9). CD34+CD38- cells were isolated from mononuclear cells from these bone marrow samples, and K562 and KG1a cells (two kinds of myeloid leukemia cell lines) by mini-magnetic activated cell sorting. Hematopoietic stem cells (HSCs) from human cord blood served as controls. Intracellular ROS level was detected by flow cytometry. DNA damage defined as the γH2AX level was measured by immunofluorescence staining. Real-time RT-PCR was used to detect the expression of p21, a senescence-associated gene. Western blotting and immunofluo-rescence staining were employed to determine the p38 expression and activation. The proliferation and apoptosis of CD34+CD38- cells were detected by MTT assay and flow cytometry. Our results showed that ROS and DNA damage were substantially accumulated and p38 was less phosphorated in myeloid leukemic CD34+CD38- cells as compared with HSCs and H2O2-induced senescent HSCs. Furthermore, over-phosphorylation of p38 by anisomycin, a selective activator of p38, induced both the senescence-like growth arrest and apoptosis of CD34+CD38- cells from K562 and KG1a cell lines. These findings suggested that, although excessive accumulation of oxidative DNA damage was present in LSCs, the relatively decreased phosphorylation of p38 might help leukemic cells escape senescence and apoptosis.     

无痛人工流产妇女的负性情绪对手术耐受性的影响

目的 探讨无痛人工流产妇女的负性情绪对手术耐受性的影响.方法 160例行无痛人工流产的妇女术前填写SCL-90症状自评量表,SCL-90总分≥160分者为负性情绪阳性组共30例,＜160分者为阴性组,共130例,比较两组术中血压、呼吸、脉搏和血氧饱和度的异常改变率、术中及术后30min的阴道出血量、麻醉剂用量、麻醉清醒后腹痛发生率、人工流产综合症发生率.结果 无痛人工流产的妇女SCL-90总分高于常模,主要存在焦虑和抑郁的负性情绪,阳性组术中生命体征异常变化发生率、阴道出血量、麻醉清醒后腹痛发生率、人流综合症发生率比较均高于阴性组(P＜0.05);阳性组麻醉剂用量明显高于阴性组(P＜0.01).结论 焦虑和抑郁的负性情绪可降低无痛人工流产妇女对手术的耐受性,应重视术前心理干预,减轻负性情绪,提高手术耐受性.     

花椒糊治好了我的脚癣

我今年63岁,患脚癣已经5年了,双脚的皮肤经常裂口、脱皮。两年前,我在书上看到用花椒糊可有效地治疗脚癣的报道,就自制花椒糊进行治疗。在连续使用花椒糊治疗半个月后,我的脚癣就治愈了。一直到现在,我的脚癣也没有复发过。花椒糊的制法是:取花椒25粒,大蒜5瓣。将大蒜捣成糊。将花椒研成细粉,调入大蒜糊中,敷在患处,每次敷20分钟,每两天用一次药。在敷此药时,患处可能会出现火烧般的疼痛感。专家点评:中医认为,脚癣是患者"脾胃湿热下注","感染湿     

纤支镜介入联合雾化吸入治疗支气管结核的临床观察

目的探讨纤支镜介入联合雾化吸入治疗支气管结核的临床应用价值。方法将126例初治菌阳支气管结核病人随机分为治疗组和对照组,两组均给予抗结核和纤支镜介入治疗,治疗组加用雾化吸入治疗。结果治疗组在痰菌转阴速度、病灶吸收好转速度、临床症状改善速度、管腔内病变吸收速度方面均优于对照组（P〈0.01）,且治疗组纤支镜介入治疗次数较对照组明显减少（P〈0.01）,从而减轻患者的痛苦,降低了患者的费用。结论纤支镜介入联合雾化吸入是治疗支气管结核的有效方法。     

无痛人工流产妇女的心理特征及相关因素分析

目的 探讨无痛人工流产(人流)女性的心理特征及其相关因素.方法 160例行无痛人流和129例行传统人流的女性术前填写一般资料调查问卷、SCL-90症状自评量袁和社会支持评定量表,对收集的资料进行t检验X2检验和多元线性逐步回归分析.结果 无痛人流组的SCL-90总分、焦虑因子分、强迫因子分和抑郁因子分较传统人流组略低,但无统计学意义,P＞0.05,恐惧因子分则明显降低,P＜0.01;与国内常模比较,无痛人流者的SCL-90总分、焦虑、抑郁、躯体化因子分均高于常模,P值均＜0.01;以无痛人流女性的SCL-90总分为因变量,可能相关的因素为自变量,进入多元线性回归方程的变量为婚姻状况、生育情况、社会支持总分.结论 无痛人工流产妇女仍然存在焦虑和抑郁的心理特征,其主要的相关因素为未婚、未生育小孩和缺乏社会支持.     

隆鼻术治疗体会

隆鼻术治疗体会肖音我科从１９９２年８月～１９９３年３月，采用右侧鼻孔内侧鼻软骨间切口置入Ｌ型硅胶假体隆鼻共３０例。男２例，女２８例。患者除鞍鼻外均伴有鼻尖圆钝、鼻翼过宽、鼻小柱相对过短等鼻形缺陷。手术在右鼻孔内软骨间切口，探入眼科尖头直剪在鼻背和鼻小...     

血浆置换联合激素治疗血栓性血小板减少性紫癜32例临床分析

目的探讨血浆置换术联合大剂量激素疗法在血栓性血小板减少性紫癜治疗中的临床应用价值。方法回顾性分析采用血浆置换术联合大剂量激素疗法治疗的32例血栓性血小板减少性紫癜患者的临床资料。结果 32例血栓性血小板减少性紫癜患者中,完全缓解28例(87.50%),近期复发3例(9.38%),因脏器功能衰竭死亡1例(3.12%),总有效率为96.88%。在治疗过程中未见明显不良反应发生。结论血浆置换术联合大剂量激素疗法是治疗血栓性血小板减少性紫癜的首选有效方法,值得临床推广。