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1.
正中国老年痴呆患者人数已居世界第一,同时也增速最快。然而,有49%的老年痴呆患者被误认为是自然老化,仅19.6%的患者接受了药物治疗,科学认知老年痴呆已刻不容缓。老年痴呆是一种老年期常见的综合征,是由脑器质性疾病引起的认知功能缺陷或衰退,可伴随精神和运动功能症状,损害患者日常生活能力。 相似文献
2.
张守字 《国际脑血管病杂志》1997,(1)
近端主动脉粥样硬化被认为是老年人潜在缺血性卒中的一个决定因素,尤其表现于不明原因的病人。作者通过比较急性缺血性卒中和无卒中对照组人群中主动脉粥样硬化的发生率,包括不同人种间的发生率,评价其作为一种独立卒中危险因素所起的潜在作用差异。 对象 选择106例急性缺血性卒中病人进行研究,114例非卒中病人作为对照组。通过经食道超声心 相似文献
3.
痴呆症的流行状况与整合管理 总被引:1,自引:0,他引:1
根据世界卫生组织1992年日内瓦<国际疾病分类(第10版)>的定义,痴呆是脑部疾病所致的综合征.其特点是认知功能的损害进行性加重,并可能伴随多种神经精神症状,如冷漠,烦躁,抑郁等,是老年人入院、致残和致死的重要原因. 相似文献
4.
目的:探讨石杉碱甲联合美金刚治疗老年性痴呆(AD)临床疗效。方法:随机抽取某院门诊及住院老年性痴呆患者42例(年龄69±4.5岁),分为对照组(20例),给予石杉碱甲(商品名:哈伯因)及一般常规治疗;试验组(22例)给予石杉碱甲联合美金刚治疗,并给予所有患者简易精神量表(MMSE)、日常生活功能量表(ADL)及神经精神科问卷(NPI)评分,治疗18周后再复查量表评分,用统计学分析方法对终点时两组量表分值作组间对照分析。结果:经组间对照t检验分析结果显示,对照组和试验组MMSE、ADL、NPI有显著性差异(P〈0.05)。结论:石杉碱甲联合美金刚治疗老年性痴呆治疗显效,较单纯应用石杉碱甲对患者的认知功能、日常生活能力及精神行为异常疗效有明显提高。 相似文献
5.
Objective To explore the risk factors for falls in patients with dementia. Methods Totally 118 patients diagnosed with dementia were divided into fails group and no fails group. The scores of mini-mental state examination (MMSE), clinical dementia rating (CDR) , activity of daily living scale (ADL), neuropsychiatric inventory (NPI) and unified Parkinson's disease rating scale (UPDRS) were compared between the two groups. The relationship between falls and their risk factors were analyzed by logistic regression model. Results The NPI and UPDRS scores were higher in falls group than in no falls group(t=2. 237,2. 213; both P<0.05). Multivariate analysis showed that dyskinesia and behavior disorders were significantly associated with an increased risk of falls (β=0.77 and 0.86, both P<0.05). Conclusions Dyskinesia and behavior disorders may be related to fails in patients with dementia and intervention measures of these risk factors are very essential. 相似文献
6.
Objective To explore the risk factors for falls in patients with dementia. Methods Totally 118 patients diagnosed with dementia were divided into fails group and no fails group. The scores of mini-mental state examination (MMSE), clinical dementia rating (CDR) , activity of daily living scale (ADL), neuropsychiatric inventory (NPI) and unified Parkinson's disease rating scale (UPDRS) were compared between the two groups. The relationship between falls and their risk factors were analyzed by logistic regression model. Results The NPI and UPDRS scores were higher in falls group than in no falls group(t=2. 237,2. 213; both P<0.05). Multivariate analysis showed that dyskinesia and behavior disorders were significantly associated with an increased risk of falls (β=0.77 and 0.86, both P<0.05). Conclusions Dyskinesia and behavior disorders may be related to fails in patients with dementia and intervention measures of these risk factors are very essential. 相似文献
7.
目的 探讨阿尔茨海默病(Alzheimer's disease,AD)患者精神行为异常与脑白质损害的相关性.方法 纳入60例60岁以上的AD患者(AD组)和40例年龄、性别相匹配的认知功能正常的老年人(对照组),盲法分析其CT资料,双侧额区、顶枕区、颞区和幕下共8个区域白质损害的总和作为白质损害的总分,并检测CT显示的脑血管病变.AD组分别进行神经精神科问卷评分(Neuropsychiatric Inventory,NPI).结果 AD组脑白质损害总分、左额区、右额区、左顶枕区、右顶枕区白质损害和脑血管病变分别为1.450±2.310、0.340±0.340、0.310±0.560、0.240±0.360、0.140±0.230和0.120±0.330,而对照组分别为9.640±1.566、1.720±0.248、1.680±0.312、1.550±0.244、0.140±0.230和2.230±0.378,两组有显著差异(P分别为0.000、0.001、0.001、0.012、0.006和0.002).Spearman相关分析表明,NPI与白质损害总评分、左额区、右额区、左顶枕区和右顶枕区白质损害评分相关,rs(P)分别为0.487(0.016)、0.490(0.014)、0.502(0.014)、0.507(0.012)和0.521(0.014),而与脑血管病变无关(rs=0.132,P=0.590).结论 脑白质损害和脑血管病变对AD的发病及病情发展至关莺要,脑白质损害与AD患者的精神行为异常密切相关. 相似文献
8.
目前老年痴呆症已经是困扰全人类的世界难题,2018年全球有5000万人罹患痴呆症,全球目前平均每3秒钟就新增一例痴呆患者,在中国65岁以上老年人群中痴呆症发生率为3.21%,目前中国痴呆症患者约有700万人。中国疾病预防控制中心最新发表于《柳叶刀》杂志上的重磅研究指出,痴呆症已经是位列中风、缺血性心脏病、慢性阻塞性肺病、肺癌之后的第五大致死疾病。 相似文献
9.
Objective To explore the risk factors for falls in patients with dementia. Methods Totally 118 patients diagnosed with dementia were divided into fails group and no fails group. The scores of mini-mental state examination (MMSE), clinical dementia rating (CDR) , activity of daily living scale (ADL), neuropsychiatric inventory (NPI) and unified Parkinson's disease rating scale (UPDRS) were compared between the two groups. The relationship between falls and their risk factors were analyzed by logistic regression model. Results The NPI and UPDRS scores were higher in falls group than in no falls group(t=2. 237,2. 213; both P<0.05). Multivariate analysis showed that dyskinesia and behavior disorders were significantly associated with an increased risk of falls (β=0.77 and 0.86, both P<0.05). Conclusions Dyskinesia and behavior disorders may be related to fails in patients with dementia and intervention measures of these risk factors are very essential. 相似文献
10.
目的 评价炎症介质白介素-2(interleukin-2,IL-2)、肿瘤坏死因子-α(tumor necrosis factor-α,
TNF-α)及尿液内源性甲醛浓度(formaldehyde,FA)与血管性痴呆(vascular dementia,VaD)的关系,为
临床VaD的早期诊断提供生化标志物诊断方法。
方法 选取北京老年医院精神心理门诊和病房VaD患者42例为试验组,选取社区内认知功能正常
者54例为对照组,测定研究对象血浆中I L-2和TNF-α的水平,测定尿液内源性甲醛的含量,以尿液中
甲醛浓度除以肌酐(creatinine,Cr)浓度值(FA/Cr)作为内源性甲醛校正浓度,比较两组上述指标的
差异。
结果 与对照组相比,VaD患者尿液内源性甲醛浓度含量显著升高(6.31±0.53 vs 4.40±0.31,
P =0.007)。
结论 VaD患者尿液中内源性甲醛浓度升高,或可作为临床诊断VaD的生物标志物之一。 相似文献