牙周组织再生结合骨皮质切开术对骨性Ⅲ类错[牙合]牙龈厚度影响的数字化评估

目的通过口内扫描技术初步探索并建立一种评价软组织改变的方法,评估牙周组织再生结合骨皮质切开术对骨性Ⅲ类错[牙合]骨嵴顶冠方牙龈厚度的影响。方法纳入2018年1月至2019年3月于北京大学口腔医学院·口腔医院正畸科和口腔颌面外科转诊至牙周科、全身和牙周健康、需行正畸-正颌联合治疗的骨性Ⅲ类错[牙合]畸形患者22例,其中男性4例,女性18例,年龄(24.0±4.5)岁(19~35岁);观测前牙共112颗,其中上颌前牙46颗,下颌前牙66颗。在前牙去代偿正畸移动前行牙周组织再生结合骨皮质切开术,观察探诊深度、出血指数、角化龈宽度,比较术前及术后6个月的差异。术前与术后6个月通过口内扫描技术直接获取患者上下颌前牙区数字化模型,在分析软件中构建软组织形态测量模型,并定量分析牙冠正中测量矢状面上龈缘根方1和2 mm处牙龈厚度的变化。结果22例患者手术前后探诊深度、出血指数差异均无统计学意义(P>0.05);术后6个月角化龈宽度从术前的(4.22±1.43)mm显著增加至(5.18±2.32)mm(P<0.05)。术后6个月上颌、下颌前牙龈缘根方1和2 mm处牙龈厚度与术前相比均显著增加(P<0.05);其中上颌前牙龈缘根方1和2 mm处牙龈厚度增加量分别为(0.68±0.56)和(1.00±0.69)mm;下颌前牙龈缘根方1和2 mm处牙龈厚度增加量分别为(0.38±0.42)和(0.58±0.45)mm;且上颌牙龈厚度增加量均显著大于下颌(P<0.01)。结论基于口内扫描技术进行软组织形态变化的定量评价方法切实可行。在骨性Ⅲ类错[牙合]正畸-正颌联合治疗中牙周组织再生结合骨皮质切开术不但能增加角化龈宽度,而且可增加骨嵴顶冠方牙龈组织厚度。     

Catalytic hydrogenolysis of larix bark proanthocyanidins in ionic liquids produces UV blockers with potential for use in cosmetics

The bark of larix, a major tree species in the coniferous forests of China''s Greater Khingan Mountains, is typically treated as waste. The bark is, however, rich in flavonoids, known as proanthocyanidins, although their high degree of polymerization and high molecular weight reduce their biological activity and potential applications. Ionic liquids, a new type of “green solvent”, characterized by low vapor pressure and good stability, have been developed and used as new solvents for naturally occurring macromolecules. Here, we used 1-butyl-3-methylimidazole chloride ([BMIM]Cl) as the ionic solvent to reduce the degree of polymerization of larix bark proanthocyanidins by Pd/C-catalyzed hydrogenolysis. The optimal reaction conditions, determined using an orthogonal experimental design, were: reaction temperature, 90 °C; reaction time, 1.5 h; catalyst loading, 4 g L⁻¹ (Pd/C: [BMIM]Cl); and hydrogen pressure, 2.5 MPa. Characterization of the reaction products by UV-Vis and IR spectroscopy and gel permeation chromatographys showed that they retained the proanthocyanidin structure. We showed that whilst both the native and depolymerized proanthocyanidins were able to block UV light when added to commercially available skin creams and sunscreens, the depolymerized proanthocyanidins were more effective at a given concentration. This study expands the applications of a new “green” ionic liquid solvent, provides a technical foundation for the low-cost depolymerization of larix bark proanthocyanidins, and also explores a potential high-value use for waste larix bark as the source of a UV-blocking additive for cosmetics.

Oligomeric proanthocyanidins with excellent UV resistance were prepared by hydrogenolysis in ionic liquids.     

舒适护理用于肺心病患者护理的探讨

目的探讨舒适护理用于肺心病患者的效果。方法对59例肺心病患者分别实施舒适护理。结果患者对护士的服务态度、护理效果满意度达100%,平均住院日及医疗费用降低。结论对肺心病患者实施舒适护理可以减少住院时间,节省医疗费用,提高患者满意度,是有效的护理措施。     

分光光度法测定车间空气中丙酮氰醇

本文建立了用分光光度法测定车间空气中丙酮氰醇的方法。主要是经硅胶管采集空气中的丙酮氰醇,利用其在碱性溶液中分解为丙酮和氰化物的性质,以异菸酸钠—巴比妥酸钠比色法,于600nm比色定量。实验表明,本法检测限为0.3μm/5ml,在0—7μg范围内有良好的线性关系;相对标准偏差为0.9％～3.4％;采样效率97.2％～99.9％;加入0.5、1、2倍(最高容许浓度时在规定采样体积下采集的)丙酮氰醇,其洗脱效率分别为95.3％、91.9％、90.4％。     

胃肠减压引流不畅的原因分析

目的总结胃肠减压引流不畅的原因及护理对策。方法胃肠减压引流不畅的原因有:胃管阻塞,置管长度不当,吸引负压不当。结果通过分析胃肠减压引流不畅的原因,并采取相应的护理对策,保证了胃肠减压持续有效。115例患者胃肠减压过程顺利,治愈出院,无发生并发症及其它意外。结论通过对胃肠减压引流不畅的原因进行分析,并采取相应的护理对策,保证了胃肠减压持续有效,提高了手术成功率和治疗效果。     

双氯芬酸钠缓释胶囊在不同PH中释放度的考察实验

目的：考察不同pH条件下药物的体外释放度。方法：采用不同pH的释放介质,按《中国药典》2000年版体外释放度转篮法测定双氯芬酸钠缓释胶囊的释放情况。结果：该药的释放受pH值的影响较大。结论：采用pH＝6的介质作为体外释放试验较为理想。     

食管多原发癌与上消化道重复癌--附32例报告

目的探讨食管多原发癌与上消化道重复癌的诊断与治疗方法.方法总结我院32例多原发食管癌与上消化道重复癌,采取不同的诊断和手术方法,结合化疗等综合性治疗经验.结果全组随访时间8个月～6年,其中1年内死亡6例,1～2年死亡12例,2～3年死亡9例,3～6年死亡4例,生存6年以上者1例.结论经综合性治疗后,较好地延长了患者生命,提高了生活质量.     

Hyperspectral images classification with convolutional neural network and textural feature using limited training samples

In this letter, a new deep learning framework, which integrates textural features of gray level co-occurrence matrix (GLCM) into convolutional neural networks (CNNs) is proposed for hyperspectral images (HSIs) classification using limited number of labeled samples. The proposed method can be implemented in three steps. Firstly, the GLCM textural features are extracted from the first principal component after the principal components analysis (PCA) transformation. Secondly, a CNN is built to extract the deep spectral features from the original HSIs, and the features are concatenated with the textural features obtained in the first step in a concat layer of CNN. Finally, softmax is employed to generate classification maps at the end of the framework. In this way, the CNN focuses on the learning of spectral features only, and the generated textural features are used directly as one set of features before softmax. These lead to the reduction of the requirements for the size of training samples and the improvement of computing efficiency. The experimental results are presented for three HSIs and compared with several advanced deep learning and spectral-spatial classification techniques. The competitive classification accuracy can be obtained, especially when only a limited number of training samples are available.     

Opal: an implementation science tool for machine learning clinical decision support in anesthesia

Journal of Clinical Monitoring and Computing - Opal is the first published example of a full-stack platform infrastructure for an implementation science designed for ML in anesthesia that solves...     

阴道超声对输卵管妊娠保守治疗的观察与分析

目的探讨阴道超声对未破裂型输卯管妊娠保守治疗过程中检测的必要性。方法对未破裂型输卵管妊娠患者分别于服药前及服药后，连续动态观察异位妊娠组织及非均质包块的形成发展与转归。结果本文对60例未破裂型输卵管妊娠给予口服米非司酮保守治疗6～8周，内异位妊娠包块消失44例；未破裂流产型10例；无效6例。其中，服药600mg后无效1例，服药400mg后破裂1例。结论阴道超声对异位妊娠可提早作出准确诊断，协助临床随时掌握病情变化，指导临床及时采取有效治疗措施有重要意义。