排序方式: 共有13条查询结果,搜索用时 93 毫秒
1.
The experimental research showed the fine-film coating based on hafnium nitride to inhibit the pathogenic microflora and to exert the bactericidal effect by far less versus that of antibiotics; at the same time, the concentration of hafnium ions in the solution is just within the sensitivity limit detectable by the most recent registration methods--it amounts to less than 10(-10) mol/l. Therefore, according to the research results, the use of such coatings based on hafnium nitride is promising in manufacturing the surgical metal implants and medical instruments. 相似文献
2.
R. I. Mustafin T. V. Kabanova E. R. Zhdanova A. V. Bukhovets V. R. Garipova Sh. F. Nasibullin V. A. Kemenova 《Pharmaceutical Chemistry Journal》2010,44(3):147-150
New interpolyelectrolyte complexes (IPEC) between Eudragit? EPO (EPO) and Carbomer 940 (C940) were synthesized for assessment as controlled-release delivery carriers for oral systems.
Depending on the structural properties, the resulting IPEC were distinct from the individual (co)polymers and their physical
mixtures in terms of their swelling profiles in media simulating the gastrointestinal tract. Changes in structure and composition
occurring within the polycomplex matrix on swelling were studied by IR spectroscopy, MT-DSC (modulated temperature differential
scanning calorimetry), and elemental analysis. The mechanism underlying the transport of the model drug ibuprofen from the
polycomplex matrix was identified. 相似文献
3.
R. I. Mustafin A. V. Bukhovets A. Yu. Sitenkov V. R. Garipova V. A. Kemenova P. Rombaut G. Van den Mooter 《Pharmaceutical Chemistry Journal》2011,45(9):568-574
With a view to the development of peroral controlled drug delivery systems, a new interpolyelectrolyte complex (IPEC) between
oppositely charged types of Eudragit?, EPO and S100, has been synthesized and investigated at neutral pH values. According
to data of turbidimetry, capillary viscometry, gravimetry, and elemental analysis, the obtained IPEC has a composition of
Z = [EPO]/[S100] = 1.26. Structural features of the IPEC samples have been evaluated by FTIR spectroscopy and modulated-temperature
differential scanning calorimetry. The results confirmed that the IPEC is stabilized by cooperative intermacromolecular ionic
bonds, is chemically homogeneous, and is characterized by a single glass transition temperature. The observed features of
the carrier swelling and diclofenac sodium release from the matrix system confirm that the proposed IPEC has great potential
to be used as a carrier for controlled colon-specific drug delivery. 相似文献
4.
5.
R. I. Mustafin T. V. Kabanova I. I. Semina A. V. Bukhovets V. R. Garipova E. V. Shilovskaya Sh. F. Nasibullin A. Yu. Sitenkov R. R. Kazakova V. A. Kemenova 《Pharmaceutical Chemistry Journal》2011,45(8):491-494
The biopharmaceutical properties of a new drug carrier based on an interpolyelectrolyte complex (IPEC) between Carbomer 940
and Eudragit? EPO have been studied in the form of a polycomplex matrix system (PMS) intended to be a potential carrier for peroral drug
delivery systems. The release profiles of diclofenac sodium from the proposed PMS and Voltaren? retard in model gastroitestial tract medium belong to the intestine-soluble and sustained-release types, respectively. Evaluation
of the pharmacokinetic parameters of the PMS revealed a close in vitro/in vivo correlation. The proposed PMS, in contrast to the parent drug, provides targeted drug delivery to the colon region and is
comparable with Voltaren? retard with respect to the bioavailability and the main pharmacokinetic parameters. 相似文献
6.
7.
R. I. Mustafin T. V. Kabanova E. R. Zhdanova A. V. Bukhovets V. R. Garipova Sh. F. Nasibullin V. A. Kemenova 《Pharmaceutical Chemistry Journal》2010,44(5):271-273
The formation of interpolyelectrolyte complexes (IPEC) between Eudragit? EPO (EPO) and Carbomer 940 (C940) was investigated with a view to their use in peroral controlled-release drug delivery systems.
The structure of the synthesized products was investigated using FTIR spectroscopy and MT—DSC methods, which indicated that
the synthesized product can be considered to be an IPEC stabilized by a cooperative system of ionic bonds. Based on results
of capillary viscosimetry and elemental analysis, the IPEC prepared at pH 4.0 has a characteristic composition with a C940:EPO
mole ratio of 1.75:1. 相似文献
8.
9.
Vladimir Burilov Ramilya Garipova Diana Mironova Elza Sultanova Ilshat Bogdanov Evgeny Ocherednyuk Vladimir Evtugyn Yuri Osin Ildar Rizvanov Svetlana Solovieva Igor Antipin 《RSC advances》2020,11(1):584
A new imidazolium amphiphilic calix[4]arene with terminal acetylene fragments in the polar region was synthesized according to a two step scheme including regioselective chloromethylation of distal di-O-butyl calix[4]arene and subsequent interaction with 1-(hex-5-yn-1-yl)-1H-imidazole. The aggregation properties (CAC, the size and zeta potential of aggregates) of alkynyl calix[4]arene as well as of previously synthesized azidopropyl calix[4]arene and their 1 : 1 mixture were disclosed. Macrocycles with azide and alkyne fragments in the polar region were covalently cross-linked under CuAAC conditions in water. Successful cross-linking of molecules has been proven by IR spectroscopy and MALDI-TOF spectrometry. The obtained polymeric particles were studied both in solution and the solid state and the presence of submicron (∼200 nm) and micron (∼1–5 μm) particles with the prevalence of the latter was found. The average molecular weight of the polymer according to the static light scattering data was found to be 639 ± 44 kDa. The obtained polymeric imidazolium–triazole particles were tested as a support for Pd(OAc)2 in the Mizoroki–Heck reaction carried out in both organic and water media. In both solvents (especially in water) the addition of imidazolium–triazole particles to Pd(OAc)2 increased the conversion of 4-iodanisole. It was found that the ratio between the products (1,1 and 1,2-substituted ethylenes) changes drastically on going from DMF to water from 1 : 5 to 1 : 40 when using supported Pd(OAc)2.A new supramolecular approach to the formation of polytriazole–imidazolium particles, promising supports for catalysis, based on self-assembly of amphiphilic bis-azides and bis alkynes and their linkage using CuAAC is presented. 相似文献
10.
An analytical model of dynamic imaging of the prostate gland during prostate transurethral resection is described. The structure
of a system of dynamic image processing for guiding resectoscope motion inside the prostate was developed. A trajectory processing
technique for dynamic imaging is suggested and analyzed. 相似文献