全文获取类型
收费全文 | 318篇 |
免费 | 17篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 10篇 |
妇产科学 | 1篇 |
基础医学 | 26篇 |
口腔科学 | 1篇 |
临床医学 | 107篇 |
内科学 | 111篇 |
皮肤病学 | 2篇 |
神经病学 | 4篇 |
外科学 | 28篇 |
综合类 | 2篇 |
预防医学 | 15篇 |
药学 | 27篇 |
出版年
2016年 | 5篇 |
2015年 | 15篇 |
2014年 | 7篇 |
2013年 | 12篇 |
2012年 | 5篇 |
2011年 | 5篇 |
2010年 | 19篇 |
2009年 | 21篇 |
2008年 | 2篇 |
2007年 | 5篇 |
2006年 | 5篇 |
2005年 | 5篇 |
2003年 | 10篇 |
2002年 | 2篇 |
2001年 | 9篇 |
2000年 | 5篇 |
1999年 | 13篇 |
1998年 | 22篇 |
1997年 | 18篇 |
1996年 | 17篇 |
1995年 | 13篇 |
1994年 | 6篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1966年 | 3篇 |
1959年 | 2篇 |
1958年 | 5篇 |
1957年 | 4篇 |
1956年 | 5篇 |
1955年 | 3篇 |
1954年 | 6篇 |
1933年 | 2篇 |
1930年 | 1篇 |
排序方式: 共有335条查询结果,搜索用时 15 毫秒
1.
PIERRE VULLIEMIN ALESSANDRO DEL BUFALO JURG SCHLAEPFER MARTIN FROMER LUKAS KAPPENBERGER 《Pacing and clinical electrophysiology : PACE》1994,17(8):1391-1398
Assuming that type I atrial flutter is a macroreentrant circuit, its cycle length should vary with the atrial dimensions. In order to test this hypothesis, flutter cycle length was measured while inducing atrial volume and pressure changes by postural and pharmacological means in seven patients undergoing a therapeutic programmed stimulation for type 1 atrial flutter conversion. Right atrial volume was estimated from B-mode echocardiography data. Basal values were compared with those obtained during inspiration, expiration, Valsalva maneuver, negative tilt (head down), and positive tilt (head up) with 0.8–1.6 mg p.o. nitroglycerin. The right atrial size increased slightly from 17.8 to 18.3 cm2 (P = 0.04) during the pressure load induced by negative tilt (+ 3 mmHg), with a corresponding lengthening of the flutter cycle length from 228 to 233 msec (P = 0.02). Similarly, pressure unloading of -2 mmHg by positive tilting and nitrates was accompanied by a decrease in right atrial size to 16.6 cm2 (P = 0.04), with a corresponding decrease in cycle length from 228 to 219 msec (P = 0.03). Respiratory maneuver yielded similar results with an inspiratory cycle lengthening, expiratory shortening, and further shortening during Valsalva maneuver. These experiments demonstrate a direct relation between cycle length and atrial volume in human type I atrial flutter. They underline the importance of the right heart preload and atrial size for the electrophysiological characteristics of type I atrial flutter. Beside its fundamental interest, this finding is important for the understanding of the mechanism of maintenance and therapeutic responses of this common arrhythmia. 相似文献
2.
OSWALDO M. TISCORNIA M.D. F.A.C.G. DENIS LEVESQUE M.D. HENRI SARLES M.D. ALEXANDRE BRETHOLZ M.D. MIGHEL VOIROL M.D. JOAO P. MENDES DE OLIVEIRA M.D. MANFRED SINGER M.D. PIERRE DEMOL M.D. 《The American journal of gastroenterology》1977,67(2):121-130
In five dogs with chronic gastric fistulas (Thomas cannula) and a new type of chronic pancreatic fistula which permits collection of pure nonactivated pancreatic juice after ingestion of a test meal, the following series of experiments were performed: In the first series, a test meal (400 gm. canned dog meat) was given with 200 ml. saline simultaneously infused through the gastric cannula. In response to this stimulus, the 20-minute peak pancreatic flow rate and bicarbonate output were respectively 33% and 34%, of the maximal secretion of the pancreatic gland obtained with secretin in six control dogs provided with gastric and the classical Thomas duodenal fistula. The 20-minute peak protein output represented 84% of the maximal secretory capacity attained with dose-response curves to CCK in the same group of control animals.
In the second series either 1.5 or 2.0 gm./kg. ethanol were given instead of saline. Intragastric ethanol induced a dissociation of pancreatic secretion: a significant inhibition of flow rate, of bicarbonate concentration and output and a significant rise of protein concentration; protein output remaining unchanged.
It is postulated that ethanol, acting on the stomach and duodenojejunum, evokes, independently of its gastrin-releasing capacity', an unknown humoral or nervous mechanism that counteracts the ethanol-elicited cholinergic-mediated inhibition of pancreatic protein secretion which has been previously described. 相似文献
In the second series either 1.5 or 2.0 gm./kg. ethanol were given instead of saline. Intragastric ethanol induced a dissociation of pancreatic secretion: a significant inhibition of flow rate, of bicarbonate concentration and output and a significant rise of protein concentration; protein output remaining unchanged.
It is postulated that ethanol, acting on the stomach and duodenojejunum, evokes, independently of its gastrin-releasing capacity', an unknown humoral or nervous mechanism that counteracts the ethanol-elicited cholinergic-mediated inhibition of pancreatic protein secretion which has been previously described. 相似文献
3.
HUBERT COCHET M.D. YUKI KOMATSU M.D. FREDERIC SACHER M.D. AMIR SHERWAN JADIDI M.D. DANIEL SCHERR M.D. MATTHIEU RIFFAUD M.D. NICOLAS DERVAL M.D. ASHOK SHAH M.D. LAURENT ROTEN M.D PATRIZIO PASCALE M.D. JATIN RELAN Ph.D. MAXIME SERMESANT Ph.D. NICHOLAS AYACHE Ph.D. MICHEL MONTAUDON M.D. Ph.D. FRANÇOIS LAURENT M.D. MÉLÈZE HOCINI M.D. MICHEL HAÏSSAGUERRE M.D. PIERRE JAÏS M.D. Ph.D . 《Journal of cardiovascular electrophysiology》2013,24(4):419-426
MDCT/MRI Fusion for the Guidance of VT Ablation . Background: Delayed enhancement (DE) MRI can assess the fibrotic substrate of scar‐related VT. MDCT has the advantage of inframillimetric spatial resolution and better 3D reconstructions. We sought to evaluate the feasibility and usefulness of integrating merged MDCT/MRI data in 3D‐mapping systems for structure–function assessment and multimodal guidance of VT mapping and ablation. Methods: Nine patients, including 3 ischemic cardiomyopathy (ICM), 3 nonischemic cardiomyopathy (NICM), 2 myocarditis, and 1 redo procedure for idiopathic VT, underwent MRI and MDCT before VT ablation. Merged MRI/MDCT data were integrated in 3D‐mapping systems and registered to high‐density endocardial and epicardial maps. Low‐voltage areas (<1.5 mV) and local abnormal ventricular activities (LAVA) during sinus rhythm were correlated to DE at MRI, and wall‐thinning (WT) at MDCT. Results: Endocardium and epicardium were mapped with 391 ± 388 and 1098 ± 734 points per map, respectively. Registration of MDCT allowed visualization of coronary arteries during epicardial mapping/ablation. In the idiopathic patient, integration of MRI data identified previously ablated regions. In ICM patients, both DE at MRI and WT at MDCT matched areas of low voltage (overlap 94 ± 6% and 79 ± 5%, respectively). In NICM patients, wall‐thinning areas matched areas of low voltage (overlap 63 ± 21%). In patients with myocarditis, subepicardial DE matched areas of epicardial low voltage (overlap 92 ± 12%). A total number of 266 LAVA sites were found in 7/9 patients. All LAVA sites were associated to structural substrate at imaging (90% inside, 100% within 18 mm). Conclusion: The integration of merged MDCT and DEMRI data is feasible and allows combining substrate assessment with high‐spatial resolution to better define structure–function relationship in scar‐related VT. (J Cardiovasc Electrophysiol, Vol. 24, pp. 419‐426, April 2013) 相似文献
4.
PHILIPPE MAURY M.D. EMILIE THOMSON M.D. ANNE ROLLIN M.D. MATHIEU BERRY M.D. THOMAS COGNET M.D. ALEXANDRE DUPARC M.D. PIERRE MONDOLY M.D. MATHIEU GAUTIER M.D. OLIVIER LAIREZ M.D. SIMON MÉJEAN M.D. PIERRE MASSABUAU M.D. CHRISTELLE CARDIN M.D. STÉPHANE COMBES M.D. JEAN‐PAUL ALBENQUE M.D. NICOLAS COMBES M.D. 《Pacing and clinical electrophysiology : PACE》2015,38(5):617-624
5.
PASQUALE PETRILLI PIERO PUCCI J. PIERRE PELISSIER FRANCESCO ADDEO 《Chemical biology & drug design》1987,29(4):504-508
Degradation by pig pancreatic juice of a beta-casomorphin-containing fragment (tryptic peptide corresponding to residues 49–68 of buffalo beta-casein) was investigated. The FAB/MS (fast atom bombardment mass spectrometry) technique was used to identify the fragments produced by the concerted action of pancreatic proteases. Pancreatic juice, under our experimental conditions, is not able to release beta-casomorphins or morphiceptin from the tryptic peptide sequence. Furthermore, the present report shows that the rapid hydrolysis of a peptide bond by a single protease can prevent the cleavage of peptide bonds by a different protease. Therefore the formation of some peptides in the gastrointestinal tract can depend on the protease ratio. 相似文献
6.
MOHAMED BOUTJDIR JEAN YVES LE HEUZEY THOMAS LAVERGNE SYLVAIN CHAUVAUD LOUIS GUIZE ALAIN CARPENTIER PIERRE PERONNEAU 《Pacing and clinical electrophysiology : PACE》1986,9(6):1095-1100
Spatial inhomogeneity of refractory periods, as measured during clinical electrophysiological studies, is a known predisposing factor of arrhythmia. We studied elective refractory periods (ERP) and action potential duration (ADP90 ) on isolated human atrium. Twelve samples of right atrium obtained during cardiac surgery from patients with (n = 6) and without (n = 6) atrial fibrillation (AF) were studied by microelectrode technique. For each preparation, ERP were measured at basic cycle lengths (BCL) of 1,600, 1,200, 800, and 400 msec in five different cells located around (0.8 mm) the stimulating electrode. Dispersion of ERP was significantly greater in the AF group (96.7 ± 9 versus 70.9 ± 9 msec, p = 0.01). In the non-AF group, we observed a positive linear correlation between (1) ERP and BCL (f = 0.86) (2) ADP90 and BCL (= 0.93). On the contrary, in the AF group this correlation was absent between ERP and BCL (= 0.28), poor between ADP90 and BCL (= 0.62). These results suggest that nonhomogeneous recovery of excitability (dispersion and poor adaptation) may be an important factor of arrhythmia. This inhomogeneity is present at the cellular level as well as in the entire heart. 相似文献
7.
RUKSHEN WEERASOORIYA M.B.B.S. † PIERRE JAIS M.D. NICOLAS LELLOUCHE M.D. MATTHEW WRIGHT M.D. SEBASTIEN KNECHT M.D. ISABELLE NAULT M.D. SHINSUKE MIYAZAKI M.D. FREDERIC SACHER M.D. MELEZE HOCINI M.D. CHRISTOPHE SCAVEE M.D. LAURENT MACLE M.D. MICHEL HAISSAGUERRE M.D. 《Journal of cardiovascular electrophysiology》2009,20(3):349-351
8.
ERIC N. PRYSTOWSKY M.D. PIERRE JAÏS M.D. † PETER KOWEY M.D. ‡ STANLEY NATTEL M.D. § JEREMY N. RUSKIN M.D. ¶ 《Journal of cardiovascular electrophysiology》2008,19(S1):S1-S12
Atrial fibrillation (AF) is the most common outpatient arrhythmia. The recent ACC/AHA/ESC guidelines outline a variety of approaches to the management of AF, but their implementation into clinical practice requires multi-faceted patient evaluations and assessments for optimizing patient care. Using a case-based approach, issues such as rate versus rhythm control, anticoagulation, cardioversion, pharmacological and catheter ablation for maintenance of sinus rhythm, and the pathophysiology of AF are discussed. These data were originally presented at a satellite symposium titled Case Studies with the Experts: Management Decisions in AF , held on May 10, 2007, during the annual Heart Rhythm Society meeting. 相似文献
9.
GISSLER MIKA; GERAEDTS MAX; HEMMINKI ELINA; BUEKENS PIERRE 《European journal of public health》1998,8(3):227-231
The amount of prenatal care and the relationship between insufficientprenatal care, mothers' characteristics and infant outcome werestudied in Finland and in Baden-Württemberg, Germany. Themain sources of data were the Finnish Medical Birth Register(N=193,659) and the Perinatal Survey of Baden-Württemberg(N=307,152) in 19911993. Insufficient prenatal care wasdefined as no visits, 1 or 2 visits or late attendance. Mostof the women - also those in the risk groups for low use ofcare (foreigners, young mothers, grand multiparas, single mothersand women with a poor social status) - were using prenatal careextensively. The proportion of women having insufficient carewas 3.4% in Finland and 8.1% in Baden-Württemberg, mostof them being late attenders. Among women with insufficientcare, 39% in Finland and 55% in Baden-Württemberg werefrom the risk groups identified. Foreign nationals contributed10% of the women with insufficient care in Finland and 44% inBaden-Württemberg. The group of women with insufficientprenatal care was heterogeneous and it could not be definedby using traditional risk factors only. Infants of mothers withfew prenatal visits had poorer outcomes, but the attributableproportion of insufficient prenatal care to infant outcome wassmall. 相似文献
10.
JEAN-ALAIN FEHRENTZ RENE SEYER ANNIE HEITZ PIERRE FULCRAND BERTRAND CASTRO PIERRE CORVOL 《Chemical biology & drug design》1986,28(6):628-636
The [Tyr40]preprorenin (40–50) peptide methyl ester, an undecapeptide related to the human renin prosegment, has been synthesized using a stepwise strategy with hydrogenolisable protections on the side chains. The final deprotection was very difficult as observed by 1 H NMR and reversed phase HPLC. 2D 1 H NMR spectroscopy of the purified peptide allowed the assignment of all protons. 相似文献