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Qiang Zou Yiwei ZhongHairui Su Youmin KangJin Jin Qiang LiuShuang Geng Gan ZhaoBin Wang 《Vaccine》2010
Praziquantel (PZQ), which is used to treat all forms of schistosomiasis, has been shown to induce strong T cell activities and decrease T regulatory cell levels. In our study, we investigated whether PZQ may be used as an adjuvant for a hepatitis B surface antigen (HBsAg) DNA vaccine (pcD-S2) in eliciting strong humoral and cellular responses. Our data demonstrate that PZQ as an adjuvant increased T cell proliferation and an HBsAg-specific antibody response that was characterized by a higher ratio of IgG2a/IgG1. Moreover, a higher level of IFN-γ in CD4+ and CD8+ T cells were elicited. In addition, a significantly antigen-specific cytotoxic T lymphocyte response was also observed. The expression of TGF-β can be induced by HBsAg, while PZQ as an adjuvant can inhibit the expression of TGF-β and TGF-β/Smad2,3 signaling. The frequency of CD4+CD25+Foxp3+ Treg cells was reduced. Importantly, the regulatory function of CD4+CD25+ Treg cells was correspondingly impaired. Together, these results suggest that PZQ can enhance humoral and cellular responses to HBsAg DNA vaccination through inhibition TGF-β/Smad2,3 signaling. 相似文献
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