全文获取类型
收费全文 | 6598篇 |
免费 | 500篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 214篇 |
妇产科学 | 145篇 |
基础医学 | 988篇 |
口腔科学 | 97篇 |
临床医学 | 716篇 |
内科学 | 1282篇 |
皮肤病学 | 164篇 |
神经病学 | 715篇 |
特种医学 | 165篇 |
外科学 | 638篇 |
综合类 | 53篇 |
一般理论 | 11篇 |
预防医学 | 688篇 |
眼科学 | 114篇 |
药学 | 427篇 |
中国医学 | 9篇 |
肿瘤学 | 636篇 |
出版年
2024年 | 10篇 |
2023年 | 99篇 |
2022年 | 177篇 |
2021年 | 303篇 |
2020年 | 210篇 |
2019年 | 272篇 |
2018年 | 267篇 |
2017年 | 227篇 |
2016年 | 241篇 |
2015年 | 233篇 |
2014年 | 312篇 |
2013年 | 395篇 |
2012年 | 597篇 |
2011年 | 554篇 |
2010年 | 275篇 |
2009年 | 280篇 |
2008年 | 422篇 |
2007年 | 411篇 |
2006年 | 367篇 |
2005年 | 344篇 |
2004年 | 280篇 |
2003年 | 252篇 |
2002年 | 232篇 |
2001年 | 32篇 |
2000年 | 20篇 |
1999年 | 19篇 |
1998年 | 33篇 |
1997年 | 18篇 |
1996年 | 19篇 |
1995年 | 15篇 |
1994年 | 17篇 |
1993年 | 20篇 |
1992年 | 10篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1988年 | 10篇 |
1987年 | 5篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 9篇 |
1981年 | 11篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1977年 | 5篇 |
1969年 | 6篇 |
1958年 | 3篇 |
1954年 | 3篇 |
1926年 | 3篇 |
排序方式: 共有7117条查询结果,搜索用时 31 毫秒
1.
Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra‐ and extracellular modifications are needed to make functional collagen molecules, intracellular post‐translational modifications of proline and lysine residues having key roles in this. In this article, we provide a review on the enzymes responsible for the proline and lysine modifications, that is collagen prolyl 4‐hydroxylases, 3‐hydroxylases and lysyl hydroxylases, and discuss their biological functions and involvement in diseases. 相似文献
2.
Martin R. Späth Malte P. Bartram Nicolàs Palacio-Escat K. Johanna R. Hoyer Cedric Debes Fatih Demir Christina B. Schroeter Amrei M. Mandel Franziska Grundmann Giuliano Ciarimboli Andreas Beyer Jayachandran N. Kizhakkedathu Susanne Brodesser Heike Göbel Jan U. Becker Thomas Benzing Bernhard Schermer Martin Höhne Markus M. Rinschen 《Kidney international》2019,95(2):333-349
3.
4.
5.
6.
7.
Seena Fazel Johanna Philipson Lisa Gardiner Rowena Merritt Martin Grann 《Journal of neurology》2009,256(10):1591-1602
The objectives of this study were to systematically review and meta-analyze the research literature on the association of common neurological disorders and violence. Keywords relating to neurological disorders and violence were searched between 1966 and August 2008. Case–control and cohort studies were selected. Odds ratios of violence risk in particular disorders compared with controls were combined using fixed-effects meta-analysis with the data presented in forest plots. Sensitivity analyses were conducted to identify possible differences in risk estimates across surveys. Information on risk factors for violence was extracted if replicated in more than one study. Nine studies were identified that compared the risk of violence in epilepsy or traumatic brain injury compared with unaffected controls. For the epilepsy studies, the overall pooled odds ratio for violent outcomes was 0.67 [95% confidence interval (CI) 0.46–0.96]. For traumatic brain injury, the odds ratio was 1.66 (95% CI 1.12–2.31). An additional 11 case–control studies investigated factors associated with violence in epilepsy and traumatic brain injury. It was not possible to meta-analyze these data. Comorbid psychopathology was associated with violence. Data on other neurological conditions was limited and unreplicated. In conclusion, although the evidence was limited and methodological quality varied, epilepsy and traumatic brain injury appeared to differ in their risk of violence compared with control populations. Longitudinal studies are required to replicate this review’s provisional findings that epilepsy is inversely associated with violence and that brain injury modestly increases the risk, and further research is needed to provide information on a broader range of risk factors. 相似文献
8.
Edda TÖPFER-PETERSEN Johanna AUERBECK Angelika WEISS A.E. FRIESS and W.-B. SCHILL 《Andrologia》1986,18(3):237-251
An antiserum to the purified porcine outer acrosomal membrane (OAM) was raised in female Balb/c mice and was characterized by means of an indirect ELISA. The hyperimmune serum reacted selectively with the acrosomal cap of the sperm head and showed an extremely good cross reactivity with bull and human spermatozoa when assayed by indirect immunofluorescence. Immunoelectron microscopy using the protein A-gold method further confirmed the specificity of the anti-OAM-antiserum for the OAM. In an effort to identify the OAM antigens recognized by the hyperimmune serum and to analyse the extent of cross reactivity on a molecular level, the SDS-extractable proteins were separated by SDS-PAGE, transblotted and immunoprinted using an 125J-conjugated anti-mouse-antibody. To facilitate functional and structural analysis of distinct OAM-proteins monoclonal antibodies were generated by hybridization of mouse myeloma cells with the splenocytes of female Balb/c mice immunized with the purified OAM. One fusion resulted in about 100 anti-OAM-antibodies secreting hybridoma cultures, of which about 30% showed cross reaction with human and bull spermatozoa. Four stable cell lines were selected for this study secreting antibodies directed against the outer acrosomal membrane of boar spermatozoa. Whereas the polyclonal immune mouse serum stained the entire acrosomal cap, the four hybridoma antibodies generated a patch-work-like immunofluorescence pattern over the acrosome. HPLC-ELISA of the solubilized OAM revealed first information on the nature of the corresponding membrane antigen. 相似文献
9.
Long-term effects of physical exercise on working capacity and pulmonary function in cystic fibrosis 总被引:1,自引:0,他引:1
B Andréasson B Jonson R Kornf?lt E Nordmark S Sandstr?m 《Acta paediatrica Scandinavica》1987,76(1):70-75
Seven patients with cystic fibrosis aged 6 to 20 were enrolled for 30 months in a daily exercise program. After 12 months conventional chest physiotherapy was withdrawn. Patients with low initial Shwachman scores improved as regards maximal working capacity. Spirometric data and volume of trapped gas indicated opening of closed airways. We suggest that physical exercise in general should be the basis of pulmonary therapy in cystic fibrosis. Other forms of physiotherapy are advisable when hard physical exercise is not feasible. 相似文献
10.
Marlies Noordzij Johanna C Korevaar Elisabeth W Boeschoten Friedo W Dekker Willem J Bos Raymond T Krediet 《Nephrology, dialysis, transplantation》2006,21(9):2676-2677
Sir, With great interest we read the editorial review of Jean etal. [1] on the relationship between hyperphosphataemia and mortalityin end-stage renal disease patients. The authors summarize resultsfrom the large USRDS and DOPPS studies in which associationsof hyperphosphataemia and increased mortality risks were 相似文献