Effect of Shuxinyin (舒心饮) on In-Stent Restenosis after Coronary Artery Stenting

Objective: To evaluate the effect of anti-platelet regimens and it's combination with Shuxinyin (SXY, 舒心饮,) on in-stent restenosis after stent implantation. Methods: Forty-four patients with successful stent implantation in a coronary artery were randomly assigned to the treated group (n=20) and the control group (n=24). The treated group received: SXY and anti-platelet therapy. The control group were treated with anti-platelet regimens only. Platelet activation was assessed before and immediately after the stenting by flow cytometry, the expression of P-selectin (CD62P) and glycoprotein(GP) Ⅱb/Ⅲa receptor. It was reassessed on the 30th day after stenting. Plasma fibrinogen (Fg) and C-reaction protein (CRP) were measured by biuret and laser scattering turbidimetry respectively at the same time. Observation was made on the scoring of the symptoms of Qi deficiency syndrome, Qi-Yin deficiency syndrome and blood stasis syndrome in the two groups. Differences between groups were compared. Results: Compared with the control group, combination with SXY and anti-platelet therapy was remarkable in reducing plasma CRP (P<0.05), and also with the tendency to decrease plasma Fg, GPⅡb/Ⅲa and CD62P. It could also evidently decrease the scoring of Qi-Yin deficiency syndrome, Qi deficiency syndrome and blood stasis syndrome after stenting (P<0.05, 0.01, 0.01) respectively. Follow-up survey found 40% relapse of angina pectoris with 4 cases of in-stent restenosis proved by angiography in the treated group. But the relapse of angina pectoris in the control group was 67% with 2 cases of myocardial infarction (MI), 7 cases of in-stent restenosis proved by angiography and one death. Conclusions: Combination with SXY and anti-platelet regimens can prevent stent thrombosis and in-stent restenosis after stent implantation, and it seems superior to anti-platelet therapy only.     

宫内节育器的未耒

本文主要讨论降低IUD并发症的发生率,包括最近设计的释放左旋18-甲基炔诺酮T和产后使用的IUD。科研人员对IUD的副作用必须充分了解才能设计和提高IUD的安全性。最新的IUD是左旋18-甲基炔诺酮T。这种IUD是用Nova-T改装的,硅橡胶棒含50%左旋18-甲基炔诺酮,平均每天释放20μg左旋18-甲基炔诺酮。是否这种IUD如TCu380和MLCu375有显著避孕作用还有待于大量的临床实践验证。一项左旋18-甲基炔诺酮T IUD和Nova-T的随机比较,说明Nova-T终止率较少。经观察两年使用左旋18-甲基炔诺酮闭经妇女的终止率是11%。     

事业如日中天，“升”与“生”都难

事业渐红火，推迟生育计划 我是国际旅行社的一名小职员。没社会地位，压抑又挣扎，直到28岁生活才“阴转晴”。     

E1 Tor Vibio Cholerae Strain SM_6 and Jiangsu 1d Strain

Ｅ１ＴｏｒＶｉｂｉｏＣｈｏｌｅｒａｅＳｔｒａｉｎＳＭ_６ａｎｄＪｉａｎｇｓｕ１ｄＳｔｒａｉｎ￥ＪｉａｎｇＸｉａｏｗａｎ，ｅｔａｌ．ＡＣＴＡＡＣＡＤＥＭＩＡＥＭＥＤＩＣＩＮＡＥＮＡＮＪＩＮＧ，１９９４，１４（２）：１６３－１６４ＡｂｓｔｒａｃｔＥ１Ｔｏ?..     

The Distribution of Synaptotagmin II in RBL-2H3 and Its Regulation on Exocytosis of Lysosomes in RBL-2H3

Synaptotagmin(Syt)constitutes a family of membrane-trafficking proteins,so far nearly 20 Syts have beendiscovered.Extensive work showed that synatotagmins were a potential Ca~(2+) sensor for regulated exocytosis.Thisstudy was to investigate the expression and location of synaptotagmin Ⅱ(Syt2)in RBL-2H3(RBL)and its role inregulating exocytosis of RBL.The expression of Syt2 in RBL was confirmed by Western blot.The recombinantexpression vector pEGFP-N1-Syt2 was constructed and transfected into RBL by electroporation,the stabletransfectant RBL-Syt2-S expressing fusion protein Syt2-EGFP were obtained and Syt2 was highly concentrated atplasma membrane with little detected in cytoplasm.To analyze the role of Syt2 during exocytosis of RBL,therelease of cathepsin D was assayed by immunoblotting.Compared with control,the release of cathepsin D byRBL-Syt2-S was markedly decreased.The results indicated that Syt2 played a negative regulation in exocytosis oflysosomes in RBL.Cellular & Molecular Immunology.2005;2(3):205-209.     

本刊加入万方数据资源系统(ChinaInfo)数字化期刊群

为了实现科技期刊编辑、出版发行工作的电子化,推进科技信息交流的网络化进程,我刊现已入网“万方数据资源系统(ChinaInfo)数字化期刊群”。所以,向本刊投稿并录用的稿件文章,将一律由编辑部统一纳入万方数据资源系统(ChinaInfo),进入因特网提供信息服务。凡有不同意者,请另投它刊。本刊对编入的文稿,均不再另付稿酬。 　　万方数据资源系统数字化期刊群是国家“九五”重点科技攻关项目,截至1999年底,已有1000种期刊全文上网(网址：http:∥www.chinainfo.gov.cn/periodical)。本刊全文内容按照统一格式制作编入万方数据资源系统后,读者可通过因特网进入万方数据资源系统(ChinaInfo)免费(一年后开始酌情收费)查询浏览本刊内容,也欢迎各界朋友向我刊提出宝贵意见、建议,或订阅本刊。 《河南医学研究》编辑部 二○○一年二月第10卷     

IMPROVING ACCESS TO HEALTH SERVICES IS STRATEGIC PRIORITY OF PRODUCTIVITY DEVELOPMENT

As one of the basic human rights, health is an important guarantee for productivity. The authors introduce the Andersen's behavioral model of health service use,as well as the conception and classification of access to health services based on the model. Meanwhile,the relative guidelines and the impact on the health reform of China are discussed, compared with America's and China's. This paper propounds three strategic priority of productivity development.     

室性心律失常与心脏结构关系分析

目的：了解室性心律失常对心脏结构改变与功能的关系。方法：动态心电监测采用美国HP公司生产的双通道动态心电图系统。室性早搏按Lown分级法均大于Ⅱ级以上。彩色多普勒超声心动图仪用美国ATL公司Ultramark-9型,探头2.25MHz。结果：室性心律失常伴冠心病和高心病、肺心病组左心房、左心室扩大及射血分数下降的三组比较无显差异（P＞0．5）。以上三组与心肌炎组比较差异显（P＜0．01）。室性心动过速发生率有左心室扩大组显高于无左心室扩大组（P＜0．01）。＞60岁老年人组室性心律失常伴左心房及左心室扩大、射血分数降低显大于＜60岁非老年人组（P＜0．01）。结论：室性心律失常发生是对左室压力过度负荷,而形成左心室肥厚及心脏扩大有着密切关系,对心血管疾病发生可能性更大。