全文获取类型
收费全文 | 71篇 |
免费 | 3篇 |
专业分类
儿科学 | 3篇 |
妇产科学 | 2篇 |
基础医学 | 10篇 |
口腔科学 | 2篇 |
临床医学 | 5篇 |
内科学 | 7篇 |
神经病学 | 2篇 |
特种医学 | 1篇 |
外科学 | 35篇 |
预防医学 | 1篇 |
眼科学 | 3篇 |
药学 | 1篇 |
肿瘤学 | 2篇 |
出版年
2022年 | 1篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 4篇 |
2017年 | 4篇 |
2014年 | 2篇 |
2013年 | 3篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2009年 | 3篇 |
2008年 | 7篇 |
2007年 | 18篇 |
2006年 | 5篇 |
2004年 | 1篇 |
2002年 | 3篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有74条查询结果,搜索用时 15 毫秒
1.
2.
Fluid percussion barotrauma chamber: a new in vitro model for traumatic brain injury. 总被引:3,自引:0,他引:3
S R Shepard J B Ghajar R Giannuzzi S Kupferman R J Hariri 《The Journal of surgical research》1991,51(5):417-424
Advances in the understanding of the pathophysiology of traumatic brain injury have implicated a number of cellular events as fundamental to the evolution of neurologic dysfunction in this process. Following the primary biomechanical insult, a highly complex series of biochemical changes occur, some of which are reversible. The development of fluid percussion injury as an in vivo model for traumatic brain injury has greatly improved our ability to study this disease. However, a comparable in vitro model of biomechanical injury which would enable investigators to study the response to injury in isolated cell types has not been described. We have developed a model of transient barotrauma in cell culture to examine the effects of this form of injury on cell metabolism. This model employs the same fluid percussion device commonly used in in vivo brain injury studies. The effect of this injury was evaluated in monolayers of human glial cells. Cell viability by trypan blue exclusion and the production of leukotrienes following increasing barotrauma was investigated. This model provided a reproducible method of subjecting cells in culture to forces similar to those currently used in animal experimental head injury. 相似文献
3.
Hassan Abolhassani Janet Chou Wayne Bainter Craig D. Platt Mahmood Tavassoli Tooba Momen Marzieh Tavakol Mohammad Hossein Eslamian Mohammad Gharagozlou Masoud Movahedi Mohsen Ghadami Amir Ali Hamidieh Gholamreza Azizi Reza Yazdani Mohsen Afarideh Alireza Ghajar Arash Havaei Zahra Chavoshzadeh Asghar Aghamohammadi 《The Journal of allergy and clinical immunology》2018,141(4):1450-1458
4.
Lee H Wintermark M Gean AD Ghajar J Manley GT Mukherjee P 《Journal of neurotrauma》2008,25(9):1049-1056
Abstract Mild traumatic brain injury (mTBI) is associated with long-term cognitive deficits. This study compared the detection rate of acute post-traumatic focal lesions on computed tomography (CT) and 3T (Tesla) magnetic resonance (MR) imaging with neurocognitive outcomes. Adults (n = 36; age range, 19-52 years) with a single episode of mTBI (Glasgow Coma Scale 13-15, as well as loss of consciousness and post-traumatic amnesia) were prospectively enrolled and had CT within 24 h of injury and 3T MR within 2 weeks of injury. The CT and MR scans were reviewed by two neuroradiologists who were blinded to clinical information. Twenty-eight of these mTBI subjects and 18 matched healthy volunteers also underwent serial neurocognitive testing. Of the 36 mTBI cases, intraparenchymal lesions were detected in 18 CT and 27 acute MR exams, consisting of hemorrhagic traumatic axonal injury (TAI) (eight CT, 17 MR), non-hemorrhagic TAI (zero CT, four MR), and cerebral contusions (13 CT, 21 MR). Mild TBI patients had significantly worse performance on working memory tasks than matched controls at the acute time point (<2 weeks), and at 1 month and at 1 year post-injury; yet there was no significant correlation of imaging findings with working memory impairment. In conclusion, 3T MR detected parenchymal lesions in 75% of this mTBI cohort with loss of consciousness and post-traumatic amnesia, a much higher rate than CT. However, the CT and 3T MR imaging findings did not account for cognitive impairment, suggesting that newer imaging techniques such as diffusion tensor imaging are needed to provide biomarkers for neurocognitive and functional outcome in mTBI. 相似文献
5.
6.
Brain Trauma Foundation;American Association of Neurological Surgeons;Congress of Neurological Surgeons;Joint Section on Neurotrauma Critical Care AANS/CNS Bratton SL Chestnut RM Ghajar J McConnell Hammond FF Harris OA Hartl R Manley GT Nemecek A Newell DW Rosenthal G Schouten J Shutter L Timmons SD Ullman JS Videtta W Wilberger JE Wright DW 《Journal of neurotrauma》2007,24(Z1):S71-S76
7.
Brain Trauma Foundation;American Association of Neurological Surgeons;Congress of Neurological Surgeons;Joint Section on Neurotrauma Critical Care AANS/CNS Bratton SL Chestnut RM Ghajar J McConnell Hammond FF Harris OA Hartl R Manley GT Nemecek A Newell DW Rosenthal G Schouten J Shutter L Timmons SD Ullman JS Videtta W Wilberger JE Wright DW 《Journal of neurotrauma》2007,24(Z1):S59-S64
8.
9.
Suh M Kolster R Sarkar R McCandliss B Ghajar J;Cognitive Neurobiological Research Consortium 《Neuroscience letters》2006,401(1-2):108-113
Given that even mild traumatic brain injury (TBI) may produce extensive diffuse axonal injury (DAI), we hypothesized that mild TBI patients would show deficits in predictive smooth pursuit eye movements (SPEM), associated with impaired cognitive functions, as these processes are dependent on common white matter connectivity between multiple cerebral and cerebellar regions. The ability to predict target trajectories during SPEM was investigated in 21 mild TBI patients using a periodic sinusoidal paradigm. Compared to 26 control subjects, TBI patients demonstrated decreased target prediction. TBI patients also showed increased eye position error and variability of eye position, which correlated with decreased target prediction. In all subjects, average target prediction, eye position error and eye position variability correlated with scores related to attention and executive function on the California Verbal Learning Test (CVLT-II). However, there were no differences between TBI and control groups in average eye gain or intra-individual eye gain variability, or in performance on the Wechsler Abbreviated Scale of Intelligence (WASI), suggesting that the observed deficits did not result from general oculomotor impairment or reduced IQ. The correlation between SPEM performance and CVLT-II scores suggests that predictive SPEM may be a sensitive assay of cognitive functioning, including attention and executive function. This is the first report to our knowledge that TBI patients show impaired predictive SPEM and eye position variability, and that these impairments correlate with cognitive deficits. 相似文献
10.
Matrix metalloproteinase control of capillary morphogenesis 总被引:1,自引:0,他引:1
Matrix metalloproteinases (MMPs) play crucial roles in a variety of normal (e.g., blood vessel formation, bone development) and pathophysiological (e.g., wound healing, cancer) processes. This is not only due to their ability to degrade the surrounding extracellular matrix (ECM), but also because MMPs function to reveal cryptic matrix binding sites, release matrix-bound growth factors inherent to these processes, and activate a variety of cell surface molecules. The process of blood vessel formation, in particular, is regulated by what is widely classified as the angiogenic switch: a mixture of both pro- and antiangiogenic factors that function to counteract each other unless the stimuli from one side exceeds the other to disrupt the quiescent state. Although it was initially thought that MMPs were strictly proangiogenic, new functions for this proteolytic family, such as mediating vascular regression and generating matrix fragments with antiangiogenic capacities, have been discovered in the last decade. These findings cast MMPs as multifaceted pro- and antiangiogenic effectors. The purpose of this review is to introduce the reader to the general structure and characterization of the MMP family and to discuss the temporal and spatial regulation of their gene expression and enzymatic activity in the following crucial steps associated with angiogenesis: degradation of the vascular basement membrane, proliferation and invasion of endothelial cells within the subjacent ECM, organization into immature tubules, maturation of these nascent vessels, and the pruning and regression of the vascular network. 相似文献