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排序方式: 共有294条查询结果,搜索用时 15 毫秒
1.
Molnár B. Aroca S. Dobos A. Orbán K. Szabó J. Windisch P. Stähli A. Sculean A. 《Clinical oral investigations》2022,26(12):7135-7142
Clinical Oral Investigations - To evaluate t he long-term outcomes following treatment of RT 1 multiple adjacent gingival recessions (MAGR) using the modified coronally advanced tunnel (MCAT) with... 相似文献
2.
Thirty primary gastrointestinal non-Hodgkin's lymphoma treated between 1983-1990 were reviewed to reveal the efficacy of various treatment strategies. The average age at the diagnosis 53.6 (18-76) years. The histologic material were evaluated according to the Kiel classification: 22 patients had high grade malignant lymphoma (centroblastoma 8, immunoblastoma 6, lymphoblastoma 2, non classifiable 5, T-cell lymphoma 1) 8 patients low grade malignant lymphoma (lymphocytic 2, immunocytic 2, MALT lymphoma 1, centrocytoma 1, non-classifiable 1, pleomorph small cell lymphoma 1). 21 were primary gastric lymphoma, 5 involved the small intestine, 2 the ileocecal region, and 2 the large intestine. According to the Ann Arbor staging system 7 patients were stage I/E, 16 patients stage II/E, 5 patients stage III/E and 2 patients stage IV/E. Every patients underwent surgical resection. After surgical treatment high grade malignancies were treated with ProMACE-COPP (9) and CHOP-Bleo (10) polychemotherapy; low grade malignancies received VEP (5) and CVP (3) chemotherapy. 23 of 30 patients achived complete remission. The patients with low grade malignancy are in remission. All but one patients with high grade malignant gastric lymphoma achieved complete remission with a median of 37 (3-81) months relapse-free survival. Out of 5 cases in the small intestine only in 1 case was remission achieved. Histological type (Kiel) and surgical resection were the most important prognostic factors. 相似文献
3.
Improved cytosolic free calcium mobilization and superoxide production in bicarbonate-based peritoneal dialysis solution 总被引:1,自引:0,他引:1
Dobos G; Burger M; Kuhlmann J; Passlick-Deetjen J; Schollmeyer P; Bohler J 《Nephrology, dialysis, transplantation》1997,12(5):973-977
Background. Intraperitoneal phagocytes play an
important role in local host defence to prevent CAPD peritonitis. The
intracellular calcium [Ca2+]i is thought to be
involved in the regulation of various cell functions. This study therefore
investigates the effect of lactate-based dialysis solution (LBDS) and
bicarbonate-based dialysis solution (BBDS) on cytosolic free calcium
mobilization and superoxide production (SP) as important steps in signal
transduction and bacterial killing. Methods. We
studied changes in [Ca2+]i and SP following
stimulation with N-formyl-methionyl-leucyl-phenylalanine (fMLP) in
polymorphonuclear neutrophils (PMNs) incubated in either LBDS-pH 5.2, LBDS
adjusted to pH 7.4, 1:10 diluted spent and fresh LBDS or BBDS-pH 7.4 with
different glucose concentrations, comparing the data with cells treated
with Hanks buffer (HBSS) pH 7.4 as control. To elucidate the effect of
glucose and lactate PMNs were additionally incubated in HBSS-pH 7.4,
containing glucose (HBSS-Glu-pH 7.4) or lactate (HBSS-Lact-pH 7.4) in the
same concentrations as contained in CAPD solutions and tested as above.
PMNs were isolated from healthy blood donors and incubated with dialysis
solution 10 min prior to stimulation with fMLP.
Results. [Ca2+]i mobilization
and SP were completely inhibited in PMNs incubated in LBDS pH 5.2. pH
adjustment of LBDS to 7.4 and 1:10 dilution of spent and fresh LBDS
corrected some of the suppression of the calcium influx and superoxide
production. BBDS pH 7.4, however, preserved physiological cell function
significantly better at low (1.5 and 2.3%) glucose concentrations.
Conclusion. In comparison to conventional
lactate-based dialysis solution, pH adjusted and 1:10 diluted LBDS,
bicarbonate-based dialysis solution is more biocompatible since it
preserves significantly better neutrophil cell functions. 相似文献
4.
Twenty-four-hour ambulatory blood pressure profiles in pediatric patients after renal transplantation 总被引:2,自引:2,他引:0
Nicolaus Lingens Eva Dobos Klaus Witte Christopher Busch Björn Lemmer Günther Klaus Karl Schärer 《Pediatric nephrology (Berlin, Germany)》1997,11(1):23-26
Ambulatory blood pressure monitoring was applied in 27 pediatric patients aged 6.3 – 24.3 (median 15.0) years who had been
transplanted 1.5 – 8.4 years previously. Daytime values were compared with the mean of 10 concomitant casual blood pressure
recordings. At the time of the study, antihypertensive drugs were given to 17 patients. Inulin clearance ranged from 18 to
116 (median 66) ml/min per 1.73 m2. Ambulatory blood pressure monitoring confirmed hypertension or normotension determined by casual blood pressure measurements
in 63% of patients. The physiological nocturnal dip in blood pressure was attenuated or reversed in 8 of 27 patients. It was
reduced in all 3 patients with renal artery stenosis of the graft, in 3 of 4 patients with chronic rejection, in the only
patient with recurrent focal segmental glomerulosclerosis, and in 1 of 6 patients with past acute rejection. The dipping was
not related to inulin clearance. In conclusion, casual blood pressure measurements do not accurately reflect blood pressure
in pediatric patients transplanted more than 1.5 years previously. A reduced nocturnal dip in blood pressure may indicate
an underlying renovascular or renoparenchymal pathology. Ambulatory blood pressure monitoring should regularly be applied
in patients with renal transplants.
Received May 23, 1995; received in revised form June 18, 1996; accepted June 20, 1996 相似文献
5.
Eggermann T Kloos P Mergenthaler S Eggermann K Dobos M Ranke M Wollmann H 《Clinical genetics》2001,60(5):371-373
We report a familial deletion of (8q) detected in amniocytes of a fetus with a normal ultrasound and in the phenotypically normal mother, who has now had three pregnancy losses. Chromosome analysis of amniocytes and maternal peripheral blood cells showed an interstitial deletion of (8)(q24.13q24.22), which is distal to the region associated with Langer-Giedion syndrome (LGS) or trichorhinophalangeal (TRP) syndrome. This deletion was confirmed by fluorescence in situ hybridization with a c-myc cosmid clone and chromosome 8 painting library. 相似文献
6.
We have cloned and characterized the Drosophila X virus (DXV) genome segment B and its encoded VP1, the putative RNA-dependent RNA polymerase (RdRp) present in the virion. The 2991-bp open reading frame encodes the largest birnavirus VP1 at 977 aa, with a calculated M(r) of 112.8 kDa. As with the VP1 proteins of the type species of the other two genera in the family Birnaviridae, namely, infectious pancreatic necrosis virus (genus Aquabirnavirus) and infectious bursal disease virus (genus Avibirnavirus), the DXV (genus Entomobirnavirus) VP1 protein contains a consensus GTP-binding site and appears to possess self-guanylylation activity. All of the birnavirus VP1 proteins contain conserved RdRp motifs that reside in the catalytic "palm" domain of all classes of polymerases. However, the birnavirus RdRps lack the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RdRps. All three birnavirus RdRps do contain downstream DD motifs that could function as part of the catalytic triad. These motifs are, however, located in spatially distinct regions of the various birnavirus VP1 proteins. These results suggest that the VP1 proteins of birnaviruses form a defined subgroup of polymerases that either are lacking the conserved RdRp motif VI or have repositioned this motif to different structural regions. 相似文献
7.
8.
An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis upon Mycobacterium ulcerans infection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors in M. ulcerans may be involved in Buruli ulcer pathogenesis. 相似文献
9.
Both dsRNA genome segments of Drosophila X virus (DXV) were denatured and translated in vitro using nuclease-treated rabbit reticulocyte lysates. The synthesis of all four primary gene products was detected by polyacrylamide gel electrophoresis and autoradiography. Genome segment A (mol wt 2.3 X 10(6)) encoded polypeptides with molecular weights of 67,000 (67K), 34K, and 27K, whereas segment B (mol wt 22 X 10(6)) encoded the 110K polypeptide. The proteolytic processing of 67K which generates a 49K polypeptide in infected cells was also observed in vitro. Pulse-chase experiments indicated that synthesis of the three polypeptides encoded by genome segment A initiated independently and simultaneously, suggesting that segment A is polycistronic. Native (undenatured) DXV dsRNA could also be translated with high fidelity (vitro). The messenger activity of native dsRNA was abolished by S1 nuclease treatment but completely restored on subsequent denaturation. In vitro "pulse-chase" experiments using native dsRNA as messenger, indicated that the order of translation of polypeptides on genome segment A was 5'-67K-27K-34K-3'. 相似文献
10.
Zrubka Zsombor Vékás Péter Németh Péter Dobos Ágota Hajdu Ottó Kovács Levente Gulácsi László Hibbard Judith Péntek Márta 《The European journal of health economics》2022,23(8):1341-1355
The European Journal of Health Economics - Patient activation comprises the skills, knowledge and motivation necessary for patients’ effective contribution to their care. We adapted and... 相似文献