Blur adaptation: clinical and refractive considerations

The human visual system is amenable to a number of adaptive processes; one such process, or collection of processes, is the adaptation to blur. Blur adaptation can be observed as an improvement in vision under degraded conditions, and these changes occur relatively rapidly following exposure to blur. The potential important future directions of this research area and the clinical implications of blur adaptation are discussed.     

Serum ionic fluoride levels in haemodialysis and continuous ambulatory peritoneal dialysis patients

High serum fluoride (F-) in patients with chronic renal failure (CRF) and end-stage renal disease (ESRD) is associated with risk of renal osteodystrophy and other bone changes. This study was done to determine F- in normal healthy controls and patients with ESRD on haemodialysis (HD) or peritoneal dialysis (PD). Seventeen healthy controls (12 males, 5 females) and 39 ESRD patients on dialysis (17 males, 22 females) were recruited in the study in a community with 47.4 +/- 3.28 microM/l (range 44-51 microM/l) of F- content in drinking water. Control subjects showed a mean serum F- concentration of 1.08 +/- 0.350 microM/l. Males in control group showed slightly higher F- levels (1.15 +/- 0.334, range 0.55-1.9 microM/l) than females (0.92 +/- 0.370, range 0.6-1.5 microM/l). Mean serum F- concentration did not correlate significantly with age and sex among control subjects, whereas such correlation was observed in patients with ESRD on dialysis. Mean serum F- concentration was significantly higher in patients on dialysis (2.67 +/- 1.09, range 0.8-5.2 microM/l) than normal controls. When grouped according to sex, the mean serum F- concentration in males (3.05 +/- 1.04, range 1.8-5.2 microM/l) was significantly higher than females (2.38 +/- 1.08, range 0.8-5.2 microM/l). When patients were grouped according to age, it was observed that F- concentration was significantly higher in patients with age groups 21-70 (2.86 +/- 1.05) than those with age group 13-20 years (1.42 +/- 0.531). Thus F- concentration correlated with age and sex, being higher in males and above 20 years. Despite appreciable clearance of F- (39-90%) across the peritoneum, patients on CAPD showed higher serum F- concentration than those on HD (3.1 +/- 1.97 vs 2.5 +/- 1.137 microM/l). Of the total 39 patients on dialysis 39% had their serum F- concentration above 3.0 microM/l, posing the risk of renal osteodystrophy.      

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and genetic factors, which include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin gene on chromosome 11p15 (IDDM2). However, linkage to IDDM1 and IDDM2 cannot explain the clustering of type 1 diabetes in families, and a role for other genes is inferred. In the present report we describe linkage and association of type 1 diabetes to the CTLA-4 gene (cytotoxic T lymphocyte associated-4) on chromosome 2q33 (designated IDDM12). CTLA-4 is a strong candidate gene for T cell- mediated autoimmune disease because it encodes a T cell receptor that mediates T cell apoptosis and is a vital negative regulator of T cell activation. In addition, we provide supporting evidence that CTLA-4 is associated with susceptibility to Graves' disease, another organ- specific autoimmune disease.      

Acute non-lymphocytic leukemia with t(16;21)

A patient with ANLL FAB subtype M1 was found to possess a t(16;21)(p11;q22) and trisomy 10. The 16;21 translocation has been reported in 12 other cases of ANLL, of various subtypes, and its relationship to the disease profile is discussed.     

The Effect of Electrical Stimulation and lsokinetic Exercise on Muscular Power of the Quadriceps Femoris

The purpose of this study was to compare the power and strength changes, of the quadriceps femoris muscle group, following 6 weeks of training. Twenty-seven moderately trained, female subjects were placed into three equated groups: electrical stimulation plus isokinetic exercise (ES + IE), isokinetic exercise (IE), and electrical stimulation (ES). A CybexQ I1 isokinetic dynamometer was used for testing the quadriceps ' power and strength output at the velocities of 0, 30, 100, and 180 O/ sec. The ES + IE and ES groups received faradic stimulation (progressive from 10- 20 mA) from a Multitone Multifaradic Unit (model F283, Multitone Electric Co., London, England). In addition, the ES + IE group performed isokinetic contractions concurrently with the faradic stimulation. Thigh circumference (TC) and time to peak tension (TPT) were also calculated during the pre-, mid-, and post-tests. Results indicated that a significant power increment was evident between the pre- and posttests and the pre- and mid-tests for the combined groups (p < 0.05). However, there were no significant power increases between the three separate groups at the four velocities. Significant power differences (P c 0.05) for the combined groups between the pre- and post-tests and the pre- and mid-tests at the isokinetic velocities of 30 and OO/sec were also identified. TPT and TC did not change significantly for any group over the 6-week training period. This study indicated that the combined effects of ES + IE, IE, and ES are potentially effective means of improving power and strength; however, data did not reveal one method of training as being significantly superior to another. J Orthop Sports Phys Ther 1986;8(5):260-268.