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排序方式: 共有212条查询结果,搜索用时 31 毫秒
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Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia 总被引:4,自引:0,他引:4
Hurlemann R Boy C Meyer PT Scherk H Wagner M Herzog H Coenen HH Vogeley K Falkai P Zilles K Maier W Bauer A 《Anatomy and embryology》2005,210(5-6):519-523
The brain serotonin-2A receptor (5-HT2AR) has been implicated in both the pathology of schizophrenia and the therapeutic action of atypical antipsychotics. However,
little is known about the 5-HT2AR status before the onset of schizophrenia and before the exposure to antipsychotics. We used [18F] altanserin and positron emission tomography (PET) in a pilot study of 6 individuals suspected to be at elevated risk for
schizophrenia and seven age-matched controls to test the hypothesis that regional 5-HT2AR binding is altered in the prodromal stages of schizophrenia. Distribution volume ratios (DVRs) as a proxy for 5-HT2AR availability were significantly reduced in prefrontal cortex regions of at-risk subjects, implicating early abnormalities
of serotonergic neurotransmission that antecede the onset of schizophrenia. 相似文献
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Deemer E Bertocci G Pierce MC Aguel F Janosky J Vogeley E 《Medical engineering & physics》2005,27(1):31-39
INTRODUCTION: Falls are a major cause of morbidity and mortality in children, but are also reported falsely in child abuse. Therefore, it is of interest to understand those factors which may lead to a higher likelihood of injury in a feet-first freefall. METHODS: We used laboratory freefall experiments and a 3-year-old Hybrid III anthropomorphic test dummy (ATD) to assess head and femur injury risk. Wet and dry linoleum impact surfaces were used from three fall heights: 22, 35 and 47 in. RESULTS: For a given fall height, dry surfaces were associated with higher head injury criteria (HIC) values than wet surfaces. Changes in fall height 22-47 in. did not significantly affect HIC values for falls onto either surface. Generally, compressive and bending femur loading increased significantly for wet as compared to dry linoleum. CONCLUSIONS: In simulated feet first freefall experiments up to 47 in. using a 3-year-old test dummy, a low risk of contact type head injury and femur fracture was found. However, both fall height and surface conditions influenced femur loading and head injury measures. Future efforts should explore the risk of head injury associated with angular acceleration in freefalls. 相似文献
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Martina Hoskovcová Olga Ulmanová Otakar Šprdlík Tomáš Sieger Jana Nováková Robert Jech Evžen Růžička 《Cerebellum (London, England)》2013,12(1):27-34
Disorders of balance and gait have been observed in patients with essential tremor (ET), but their association with tremor severity remains unclear. This study aimed to evaluate postural instability and gait changes in ET patients and to investigate their relationship to tremor characteristics with regard to cerebellar dysfunction as a possible common pathogenetic mechanism in ET. Thirty ET patients (8F, mean (SD) age 55.8 (17.8), range 19–81 years) and 25 normal controls (7F, 53.0 (17.7), 19–81) were tested with the scales of Activities-specific Balance Confidence (ABC), Fullerton Advanced Balance (FAB), and International Cooperative Ataxia Rating Scale (ICARS). Posturography and gait were assessed using a Footscan® system. Tremor was evaluated by the Fahn–Tolosa–Marin Tremor Rating Scale (TRS) and accelerometry in five upper limb positions. A mean (SD) TRS sum score of 27.0 (13.2) corresponded to mild to moderate tremor severity in most patients. In comparison with controls, ET subjects exhibited lower tandem gait velocity (0.21 vs. 0.26 m/s, P?=?0.028), more missteps (0.57 vs. 0.12, P?=?0.039), and increased postural sway in tandem stance (sway area 301.1 vs. 202.9 mm2, P?=?0.045). In normal gait, step width increased with the midline tremor subscore of TRS (Pearson r?=?0.60, P?=?0.046). Moreover, significant correlations were found between age and quantitative measures of normal and tandem gait in ET patients but not in controls. ABC, FAB, and ICARS scores did not significantly differ between patients and controls. In conclusion, gait and balance alterations in ET patients occur even without subjective complaints. Their relationship with midline tremor and dependence on age suggest a connection with cerebellar dysfunction. 相似文献
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Koehler Jana Christina Georgescu Alexandra Livia Weiske Johanna Spangemacher Moritz Burghof Lana Falkai Peter Koutsouleris Nikolaos Tschacher Wolfgang Vogeley Kai Falter-Wagner Christine M. 《Journal of autism and developmental disorders》2022,52(8):3718-3726
Journal of Autism and Developmental Disorders - Reliably diagnosing autism spectrum disorders (ASD) in adulthood poses a challenge to clinicians due to the absence of specific diagnostic markers.... 相似文献
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Meermeier A. Jording M. Alayoubi Y. Vogel David H. V. Vogeley K. Tepest R. 《Journal of autism and developmental disorders》2022,52(7):3286-3293
Journal of Autism and Developmental Disorders - In this study we investigate whether persons with autism spectrum disorder (ASD) perceive social images differently than control participants (CON)... 相似文献
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Lucarini Valeria Cangemi Francesco Daniel Benyamin Daniel Lucchese Jacopo Paraboschi Francesca Cattani Chiara Marchesi Carlo Grice Martine Vogeley Kai Tonna Matteo 《European archives of psychiatry and clinical neuroscience》2022,272(6):997-1005
European Archives of Psychiatry and Clinical Neuroscience - Difficulties in interpersonal communication, including conversational skill impairments, are core features of schizophrenia. However,... 相似文献