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排序方式: 共有538条查询结果,搜索用时 15 毫秒
1.
Michihiko Fukui Maho Imoto Nobuaki Shime Tetsuo Hatanaka Hideaki Tojo 《Journal of anesthesia》1997,11(1):27-31
We developed a continuous oxygen consumption (Vo2) measurement system employed the reversed Fick method, in which Vo2 in computed from continuously measured sured arterial and mixed venous oxygen saturation assed by pulse oximetry and mixed
venous oximetry, respectively, and cardiac output by the heat deprivation technique. This system was compared with the conventional
intermittent reversed fick method in 7 patients during surgery and with indirect calorimetry in 4 intensive care unit (ICU)
patients. The Vo2 measured by the continuous reversed Fick method showed a high correlation with those simultaneously measured by the intermittent
Fick method (r=0.97,P<0.01) and by indirect calorimetry (r=0.74,P<0.01). The 95% confidence limits (bias±2 SD) of the continuous reversed Fick method were −0.6±45 ml·min−1 with the intermittent Fick method and −31±56 ml·min−1 with indirect calorimetry. The continuous Fick method is in satisfactory agreement with the conventional methods for the
measured of Vo2 and potentially allows for convenient assessment of Vo2 in critically ill patients.
This study was supported in part by Grants-in-Aid for the Encouragement of Young Scientists 01771185 and 04857171 from the
Ministry of Education, Science and Culture of Japan 相似文献
2.
Yoshida C Suzukawa K Katsura Y Shimizu S Mukai HY Hasegawa Y Imagawa S Kojima H Nagasawa T 《Cancer Genetics and Cytogenetics》2004,150(1):62-65
We describe the case of a 40-year-old man whose disease was initially diagnosed as acute myelocytic leukemia. The patient achieved remission with chemotherapy, but relapsed shortly afterwards with an acute T-cell lymphoblastic leukemia. He died of intracranial bleeding. Karyotyping analysis showed a del(9p?) as a common abnormality in the leukemic cells at onset and relapse. Fluorescence in situ hybridization analysis demonstrated allelic loss of the CDKN2A gene in cells from both stages of the disease. At relapse the leukemia cells had additional abnormalities such as add(1)(p36) and del(12)(p11). We postulate that the loss of CDKN2A is involved in leukemogenesis but does not determine the lineage of the leukemic cells. Instead, abnormalities of genes at 1p36, 12p11, or both may be involved in driving a lymphoid phenotype. 相似文献
3.
Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3)(p36;q21) 总被引:3,自引:0,他引:3
Shimizu S Suzukawa K Kodera T Nagasawa T Abe T Taniwaki M Yagasaki F Tanaka H Fujisawa S Johansson B Ahlgren T Yokota J Morishita K 《Genes, chromosomes & cancer》2000,27(3):229-238
The reciprocal translocation t(1;3)(p36;q21) is associated with myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) characterized by trilineage dysplasia, in particular dysmegakaryocytopoiesis, and a poor prognosis. As yet no molecular genetic analyses of the t(1;3) have been reported. In four patients with t(1;3), all of whom had AML-M4, which evolved from MDS, the breakpoints at 3q21 clustered within a 60-kb region centromeric to the breakpoint of the inv(3)(q21q26), whereas the breakpoints at 1p36 clustered within a 90-kb region at 1p36.3. The presence of novel clusters in both the 3q21 and 1p36 breakpoints (BCRs) suggests a common, underlying molecular mechanism for the development of t(1;3)-positive MDS/AML. The Ribophorin I (RPN1) gene close to the BCR at 3q21 was highly expressed without gross structural changes, whereas the GR6 gene located within the BCR at 3q21 was not expressed. No other highly expressed genes were isolated in a 150-kb region at 3q21. Thus, it is likely that a gene at 1p36.3 is activated by the translocation of the 3q21 region or a gene important for transformation lies on 3q21, outside the 150-kb region. Further characterization of the BCRs at 1p36.3 and 3q21 should provide important insights into the molecular genetic mechanisms involved in the genesis of t(1;3)-positive MDS/AML. Genes Chromosomes Cancer 27:229-238, 2000. 相似文献
4.
We previously reported that ammonia induced apoptosis in cultured rat hippocampal neurons with moderate increases in the intracellular calcium concentration and decreases in phospho-BAD levels. Since this suggested the involvement of calcineurin in the apoptosis, the effects of calcineurin inhibitors, 1 microM cyclosporin A and 1 microM FK506, on the ammonia-induced neuronal apoptosis were tested. Both of the inhibitors abolished the neuronal apoptosis assessed by double staining with Hoechst 33258 and anti-neurofilament antibody, and the ammonia-induced decrease in phospho-BAD Ser(155) level. Thus, calcineurin appeared to be involved in the dephosphorylation of BAD at the sites including Ser(155) in ammonia-induced apoptosis. 相似文献
5.
After fear conditioning to a tone, rats received nonawakening presentations of the tone alone during slow-wave sleep (SWS) episodes. Multiunit activity was recorded in the medial part of the medial geniculate (MGm) and in the primary auditory cortex (ACx). Although tone-evoked responses were increased in MGm and ACx during the 3 conditioning sessions, group data failed to show any significant changes during SWS. Nonetheless, the few recordings (5/29) that exhibited the strongest conditioned responses during wakefulness expressed enhanced responding during SWS. Compared with previous data obtained in MGm during paradoxical sleep, associative plastic changes were less easily expressed during SWS. These results are discussed with regard to functional changes that occur in the thalamocortical system across vigilance states. 相似文献
6.
Masashi Ogawa Maho Morikawa Masaki Kobatake Taku Murakami Yuki Yamamoto Rikiya Watanabe Katsumi Yamada Katsuhito Nishiyama Yoshiro Yasutomo Kenta Hara 《Internal medicine (Tokyo, Japan)》2022,61(16):2489
An 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25(OH)2VitD] level was elevated at 71.5 pg/mL. Computed tomography revealed masses on the bilateral ribs. The mass on the rib was biopsied and diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunostaining of the biopsy sample with the anti-CYP27B1 antibody revealed the ectopic expression of 1α-hydroxylase in the lesion. We herein report a rare case of hypercalcemia induced by the overproduction of 1,25(OH)2VitD in DLBCL ectopically expressing 1α-hydroxylase. 相似文献
7.
Maho Adachi-Katayama Yuya Kondo Shota Okamoto Ryota Sato Satoshi Morinaka Taihei Nishiyama Mayu Terasaki Toshihiko Terasaki Hirofumi Toko Mizuki Yagishita Hiroyuki Takahashi Shinya Hagiwara Hiroto Tsuboi Takayuki Sumida Isao Matsumoto 《Internal medicine (Tokyo, Japan)》2022,61(17):2671
Pleural effusion is a rare manifestation in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, which is characterized by the presence of osteoarticular lesions and dermatological involvement. We herein report a 71-year-old man with pleural effusion resulting from SAPHO syndrome. He was successfully treated using corticosteroids and has experienced no recurrence for one year. We should consider SAPHO syndrome when encountering cases of anterior chest pain and pleural fluid. 相似文献
8.
Kyle J. Burghardt Margo R. Bowman Maho Hibino Barima K. Opong-Owusu Tiffany D. Pokora Katherine Reeves Kellie M. Vile 《Research in social & administrative pharmacy》2013,9(5):542-552
BackgroundLow health literacy affects 80–90 million Americans with low-income, minority populations being more vulnerable to this condition. One method of addressing limited literacy that may be particularly well accepted within vulnerable populations is the use of educational board games in order to emphasize seeking health information from reliable sources such as pharmacists.ObjectiveThe research objective was to determine if the use of educational board games could impact community pharmacy patron intentions to seek pharmacist advice in an urban, minority, economically-disadvantaged population.MethodsFour medication-related educational games were played at an urban community pharmacy under the leadership of pharmacy students in the setting of a health party. Game messages, design, and evaluation processes were uniquely guided by community members' input. A verbally administered questionnaire measured game impact via knowledge and perception questions with responses compared between a non-randomly allocated intervention group and a control group.ResultsNinety-nine adults were included in the intervention (or game) group and 94 adults were in the control group. Game participants were significantly more likely than the control group to indicate they would seek pharmacist medication advice in the future.ConclusionEducational board games played in the setting of a health party can be a fun and effective way to convey selected health messages within an urban, minority, economically disadvantaged population. Community input into game development and layering multiple strategies for overcoming health literacy barriers were essential components of this initiative. 相似文献
9.
Atsushi Tsuzuki Yoichiro Fujioka Aiko Yoshida Sayaka Kashiwagi Maho Amano Tohru Hira Akinobu Nakamura Hideaki Miyoshi Tatsuya Atsumi Yusuke Ohba 《Journal of diabetes investigation.》2022,13(7):1134
Live‐cell imaging with fluorescent proteins (FPs) is a powerful tool for investigating the exocytosis processes of hormones. However, the secretion process of glucagon‐like peptide‐1 (GLP‐1) has not been visualized by FPs, which might be because tagging FPs inhibits GLP‐1 synthesis through the post‐translational processing from proglucagon. Here, we have developed FP‐tagged GLP‐1 by inserting FPs into the middle of GLP‐1 and adding the proglucagon signal peptide. Confocal imaging confirmed that GLP‐1 fused to FPs with high folding efficiency showed granular structure, in which secretory vesicle markers colocalized. The fluorescence intensity of FP in the culture supernatant from cells treated with KCl or forskolin was significantly increased compared with those from untreated cells. Furthermore, FP‐tagged GLP‐1 enables direct visualization of stimulation‐dependent exocytosis of GLP‐1 at a single granule resolution with total internal reflection fluorescence microscopy. FP‐tagged GLP‐1 might facilitate the screening of GLP‐1 secretagogues and the discovery of new antidiabetic drugs. 相似文献
10.