全文获取类型
收费全文 | 206818篇 |
免费 | 3319篇 |
国内免费 | 1033篇 |
专业分类
耳鼻咽喉 | 1472篇 |
儿科学 | 7002篇 |
妇产科学 | 3355篇 |
基础医学 | 21464篇 |
口腔科学 | 2036篇 |
临床医学 | 15656篇 |
内科学 | 35818篇 |
皮肤病学 | 1453篇 |
神经病学 | 18714篇 |
特种医学 | 10417篇 |
外国民族医学 | 5篇 |
外科学 | 32320篇 |
综合类 | 4790篇 |
现状与发展 | 7篇 |
一般理论 | 9篇 |
预防医学 | 19825篇 |
眼科学 | 3553篇 |
药学 | 12661篇 |
15篇 | |
中国医学 | 1699篇 |
肿瘤学 | 18899篇 |
出版年
2024年 | 60篇 |
2023年 | 412篇 |
2022年 | 1106篇 |
2021年 | 1520篇 |
2020年 | 865篇 |
2019年 | 958篇 |
2018年 | 22886篇 |
2017年 | 18099篇 |
2016年 | 20479篇 |
2015年 | 2393篇 |
2014年 | 2595篇 |
2013年 | 2727篇 |
2012年 | 9701篇 |
2011年 | 23734篇 |
2010年 | 20383篇 |
2009年 | 12828篇 |
2008年 | 21334篇 |
2007年 | 23409篇 |
2006年 | 2140篇 |
2005年 | 3672篇 |
2004年 | 4530篇 |
2003年 | 5318篇 |
2002年 | 3290篇 |
2001年 | 956篇 |
2000年 | 1127篇 |
1999年 | 730篇 |
1998年 | 454篇 |
1997年 | 417篇 |
1996年 | 252篇 |
1995年 | 256篇 |
1994年 | 229篇 |
1993年 | 158篇 |
1992年 | 196篇 |
1991年 | 252篇 |
1990年 | 260篇 |
1989年 | 179篇 |
1988年 | 138篇 |
1987年 | 117篇 |
1986年 | 93篇 |
1985年 | 76篇 |
1984年 | 52篇 |
1983年 | 57篇 |
1982年 | 54篇 |
1980年 | 60篇 |
1979年 | 33篇 |
1974年 | 36篇 |
1938年 | 60篇 |
1934年 | 30篇 |
1932年 | 56篇 |
1930年 | 46篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
目的探讨脊髓小脑共济失调2型(SCA2)致病基因ATXN2异常等位基因中间重复个体的表型和分子遗传学特点。方法针对2005—2018年中日友好医院神经科运动障碍与神经遗传病研究中心收集的1383个常染色体显性遗传共济失调家系的先证者和部分家系成员,采用荧光标记毛细管电泳片段分析方法进行动态突变检测,对携带ATXN2基因中间重复的个体进行临床表型和遗传特征分析。结果共检出163个家系(包含先证者和家系成员共203人)携带异常扩展的ATXN2基因CAG重复序列,其中93个家系中有107例的异常扩展等位基因重复次数在29~34次之间。在其中的20个亲子对中,父系遗传16个,异常等位基因的代间扩展增加0~28次,母系遗传4个,异常等位基因的代间扩展增加0~4次。结论对于临床拟诊SCA2家系患者,需对其亲代或成年子代个体进行ATXN2基因检测,以免漏诊。动态突变基因检测有助于识别中间重复的个体,对明确家系致病基因和遗传咨询至关重要。 相似文献
2.
Seyed Mehdi BagheriMofidi Majid Pouladian Seyed Behnamedin Jameie Ali Abbaspour Tehrani-Fard 《Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine》2016,39(3):717-726
Magnetic field generated by neuronal activity could alter magnetic resonance imaging (MRI) signals but detection of such signal is under debate. Previous researches proposed that magnitude signal change is below current detectable level, but phase signal change (PSC) may be measurable with current MRI systems. Optimal imaging parameters like echo time, voxel size and external field direction, could increase the probability of detection of this small signal change. We simulate a voxel of cortical column to determine effect of such parameters on PSC signal. We extended a laminar network model for somatosensory cortex to find neuronal current in each segment of pyramidal neurons (PN). 60,000 PNs of simulated network were positioned randomly in a voxel. Biot–savart law applied to calculate neuronal magnetic field and additional phase. The procedure repeated for eleven neuronal arrangements in the voxel. PSC signal variation with the echo time and voxel size was assessed. The simulated results show that PSC signal increases with echo time, especially 100/80 ms after stimulus for gradient echo/spin echo sequence. It can be up to 0.1 mrad for echo time = 175 ms and voxel size = 1.48 × 1.48 × 2.18 mm3. With echo time less than 25 ms after stimulus, it was just acquired effects of physiological noise on PSC signal. The absolute value of the signal increased with decrease of voxel size, but its components had complex variation. External field orthogonal to local surface of cortex maximizes the signal. Expected PSC signal for tactile detection in the somatosensory cortex increase with echo time and have no oscillation. 相似文献
3.
4.
5.
6.
In this paper, we introduce a new type of troubled-cell indicator to improve
hybrid weighted essentially non-oscillatory (WENO) schemes for solving the hyperbolic conservation laws. The hybrid WENO schemes selectively adopt the high-order
linear upwind scheme or the WENO scheme to avoid the local characteristic decompositions and calculations of the nonlinear weights in smooth regions. Therefore,
they can reduce computational cost while maintaining non-oscillatory properties in
non-smooth regions. Reliable troubled-cell indicators are essential for efficient hybrid
WENO methods. Most of troubled-cell indicators require proper parameters to detect
discontinuities precisely, but it is very difficult to determine the parameters automatically. We develop a new troubled-cell indicator derived from the mean value theorem
that does not require any variable parameters. Additionally, we investigate the characteristics of indicator variable; one of the conserved properties or the entropy is considered as indicator variable. Detailed numerical tests for 1D and 2D Euler equations are
conducted to demonstrate the performance of the proposed indicator. The results with
the proposed troubled-cell indicator are in good agreement with pure WENO schemes.
Also the new indicator has advantages in the computational cost compared with the
other indicators. 相似文献
7.
8.
9.
N. S. Hari Narayana Moorthy Sergio F. Sousa Maria J. Ramos Pedro A. Fernandes 《Medicinal chemistry research》2016,25(7):1340-1357
Farnesyltransferase (FTase) is one of the prenyltransferase family enzymes that catalyse the transfer of 15-membered isoprenoid (farnesyl) moiety to the cysteine of CAAX motif-containing proteins including Rho and Ras family of G proteins. Inhibitors of FTase act as drugs for cancer, malaria, progeria and other diseases. In the present investigation, we have developed two structure-based pharmacophore models from protein–ligand complex (3E33 and 3E37) obtained from the protein data bank. Molecular dynamics (MD) simulations were performed on the complexes, and different conformers of the same complex were generated. These conformers were undergone protein–ligand interaction fingerprint (PLIF) analysis, and the fingerprint bits have been used for structure-based pharmacophore model development. The PLIF results showed that Lys164, Tyr166, TrpB106 and TyrB361 are the major interacting residues in both the complexes. The RMSD and RMSF analyses on the MD-simulated systems showed that the absence of FPP in the complex 3E37 has significant effect in the conformational changes of the ligands. During this conformational change, some interactions between the protein and the ligands are lost, but regained after some simulations (after 2 ns). The structure-based pharmacophore models showed that the hydrophobic and acceptor contours are predominantly present in the models. The pharmacophore models were validated using reference compounds, which significantly identified as HITs with smaller RMSD values. The developed structure-based pharmacophore models are significant, and the methodology used in this study is novel from the existing methods (the original X-ray crystallographic coordination of the ligands is used for the model building). In our study, along with the original coordination of the ligand, different conformers of the same complex (protein–ligand) are used. It concluded that the developed methodology is significant for the virtual screening of novel molecules on different targets. 相似文献
10.
Valerie Iles 《Health care analysis》2016,24(2):105-118
This paper takes a somewhat slant perspective on flourishing and care in the context of suffering, death and dying, arguing that care in this context consists principally of ‘acts of work and courage that enable flourishing’. Starting with the perception that individuals, society and health care professionals have become dulled to death and the process of dying in Western advanced health systems, it suggests that for flourishing to occur, both of these aspects of life need to be faced more directly. The last days of life need to be ‘undulled’. Reflections upon the experiences of the author as carer and daughter in the face of her mother’s experience of death are used as basis for making suggestions about how care systems and professionals might better assist people in dealing with ‘the most grown up thing’ humans ever do, which is to die. 相似文献