全文获取类型
收费全文 | 844篇 |
免费 | 32篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 3篇 |
妇产科学 | 52篇 |
基础医学 | 129篇 |
口腔科学 | 24篇 |
临床医学 | 76篇 |
内科学 | 236篇 |
皮肤病学 | 10篇 |
神经病学 | 21篇 |
特种医学 | 20篇 |
外科学 | 123篇 |
综合类 | 1篇 |
预防医学 | 26篇 |
眼科学 | 10篇 |
药学 | 23篇 |
中国医学 | 2篇 |
肿瘤学 | 114篇 |
出版年
2023年 | 7篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 10篇 |
2019年 | 8篇 |
2018年 | 11篇 |
2017年 | 12篇 |
2016年 | 12篇 |
2015年 | 11篇 |
2013年 | 19篇 |
2012年 | 20篇 |
2011年 | 36篇 |
2010年 | 17篇 |
2009年 | 11篇 |
2008年 | 28篇 |
2007年 | 32篇 |
2006年 | 24篇 |
2005年 | 29篇 |
2004年 | 28篇 |
2003年 | 31篇 |
2002年 | 24篇 |
2001年 | 24篇 |
2000年 | 39篇 |
1999年 | 31篇 |
1998年 | 12篇 |
1996年 | 9篇 |
1995年 | 9篇 |
1993年 | 7篇 |
1992年 | 22篇 |
1991年 | 19篇 |
1990年 | 30篇 |
1989年 | 29篇 |
1988年 | 32篇 |
1987年 | 33篇 |
1986年 | 21篇 |
1985年 | 33篇 |
1984年 | 23篇 |
1983年 | 12篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1979年 | 15篇 |
1978年 | 15篇 |
1977年 | 9篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1969年 | 7篇 |
1968年 | 6篇 |
1961年 | 4篇 |
排序方式: 共有877条查询结果,搜索用时 15 毫秒
1.
2.
A Kitami K Suzuki G Hori T Akizawa M Narushima E Noguchi Y Iida F Sagawa 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(11):1505-1508
A 66-year-old woman visited our hospital for further investigation of a coin-shaped lesion in the right lower lung field. After admission, CT-scan revealed an anterior mediastinal tumor. Thymoma and lung metastasis from thymoma were suspected. At thoracotomy, an invasive thymoma involving the left phrenic nerve, the left upper lobe, and the pericardium was found, and the diagnosis of lung metastasis was made. Postoperative pathological findings showed a predominantly lymphocytic thymoma with round and oval-shaped epithelial cells, and the metastatic lung lesion revealed the same findings. Postoperative radiotherapy (4000 rads) and chemotherapy with a combination of CDDP, VDS, and CPA were administered. The metastasis of thymoma is not rare, but most often it is found after operation. In this case the diagnosis of metastatic thymoma was made pre-operatively from a solitary lung lesion. 相似文献
3.
4.
D Korita H Itoh N Sagawa S Yura M Yoshida K Kakui M Takemura M A Nuamah S Fujii 《Gynecological endocrinology》2004,18(3):130-137
Prostacyclin (PGI2), a potent uterine smooth muscle relaxant, is postulated to be a major prostaglandin (PG) secreted from the human myometrium. PGI2 metabolite concentrations in the maternal plasma were reported to be elevated during pregnancy, especially during labor. Recently, we developed cultured human myometrial cells from pregnant women and reported that cyclic mechanical stretching mimicking labor increased PGI2 secretion from these cells by up-regulating PGI2 synthase promoter activities. Since elevation of cervical/vaginal interleukin-1alpha (IL-1alpha) concentrations is also a characteristic feature of delivery, and IL-1alpha is a known stimulator of PG synthesis, we investigated a possible synergistic effect of cyclic mechanical stretching and IL-1alpha on PGI2 production in cultured human myometrial cells. Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p < 0.05 for all comparisons). However, labor-like cyclic mechanical stretching up-regulated IL-1alpha-augmented PGI2 secretion from myometrial cells obtained from non-pregnant and pregnant women 2.1- to 2.8-fold (p < 0.05 for all comparisons), but not PGE2, PGF2alpha nor TXA2. Moreover, such an augumentation of PGI2 secretion by cyclic mechanical stretching was not observed in cultured human umbilical artery nor in cultured human coronary artery smooth muscle cells. These results suggest that cyclic mechanical stretching by labor, in concert with IL-1alpha stimulation, contributes to the increase in myometrial PGI2 secretion during delivery. 相似文献
5.
6.
Endo Y Yamauchi K Tsutsui Y Ishihara Z Yamazaki F Sagawa S Shiraki K 《The Japanese journal of physiology》2002,52(5):421-427
To investigate the possible involvement of the sympathetic nervous system in pressor response during water drinking, muscle sympathetic nerve activity (MSNA), blood pressure (BP), and heart rate (HR) were continuously measured in healthy young volunteers throughout the experiments of a 5-min control, 2 min of drinking 500 ml water, and a 28-min recovery. To avoid the effects of water passing through the oropharyngeal and esophageal regions and/or effects of swallowing, an equal amount of water was directly infused to the stomach through a stomach tube for 2 min. Water drinking caused a transient increase in mean arterial pressure (MAP) and HR immediately after drinking (DeltaMAP, 12.6 +/- 2.1 mmHg; DeltaHR, +19.9 +/- 1.7 beats/min at the peak). An abrupt decrease of MSNA was observed directly during water drinking (Deltaburst rate, -6.9 +/- 1.3 bursts/min; Deltatotal activity, -2,606 +/- 491 U/min), and it increased to the baseline level thereafter. Gastric infusion had little or no effect on MAP, HR, and MSNA. The present study demonstrated that a pressor response during water drinking was associated with the attenuation of MSNA and not generated by gastric infusion of water at the same rate as in this drinking manner. In conclusion, the rapid rise in BP might be caused through stimulations from the oropharyngeal region, swallowing-induced factors, and/or a feedforward mechanism by a central descending signal from the higher brain centers. 相似文献
7.
Seminoma in a postmenopausal woman with a Y;15 translocation in peripheral blood lymphocytes and a t(Y;15)/45,X Turner mosaic pattern in skin fibroblasts.
下载免费PDF全文
![点击此处可从《Journal of medical genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
N Hoshi M Fujita M Mikuni T Fujino K Okuyama Y Handa H Yamada T Sagawa H Hareyama Y Nakahori K Fujieda J A Kant K Nagashima S Fujimoto 《Journal of medical genetics》1998,35(10):852-856
We report an unusual case of a 55 year old Japanese woman with a seminoma but relatively normal menses. The patient was a phenotypic female with late onset menarche (18 years of age), who was amenorrhoeic for the first year, followed by menses of one to three days' slight flow with dysmenorrhoea, but an otherwise normal menstrual history. A typical seminoma was removed from the left adnexal region and an immature testis was identified separately as an associated right adnexal mass. Repeated karyotypic studies on peripheral blood lymphocyte cultures showed only 46,X,-Y,t(Y;15)(q12;p13). Cytogenetic examination of the patient's younger brother, who had fathered three healthy children, showed an identical karyotype. Mosaicism of 46,X,-Y,t(Y;15)(q12;p13)/45,X cell lines was found in skin samples from the patient's elbow and genital regions, although there were no clinical stigmata of Turner syndrome. An androgen receptor binding assay of cultured genital skin fibroblasts was negative. Molecular analysis using Southern blot hybridisation, PCR, and direct DNA sequencing showed that neither the patient nor her brother had a detectable deletion or other abnormalities of Y chromosome sequences, including the SRY (sex determining region of the Y chromosome) gene sequence. These findings suggest that Turner mosaicism of the 45,X cell line may have contributed to this atypical presentation in an XY female, although we cannot exclude abnormalities of other genes related to sex differentiation. 相似文献
8.
9.
We studied the contribution of atrial contraction to ventricular filling by modelling the right heart and the associated vasculature.
Right atrial and ventricular contractions were represented by periodically varying volume elastances which are independent
of loading conditions. The values of these elastances were experimentally determined. The systemic veins, the tricuspid valve
and the pulmonary arteries were all represented by impedance networks. For these impedances we used as much experimentally
obtained information as possible. The dynamic pressure and flow waveforms observed in the model under control conditions generally
agreed with those reported in the literature. We therefore proceeded to analyze the effects of changing the time interval
between atrial systole and ventricular systole, atrial contractility, heart rate, and blood inertance. There was an optimal
atrial systole-ventricular systole interval of about 0.1 sec for ventricular filling. Stroke volume of the ventricle was enhanced
by an increase in atrial contractility, a decrease in heart rate, and an increase in blood inertance. The effect of changing
atrial compliance was found to be dependent on heart rate. Contribution of atrial contraction to ventricular filling was also
found to be more significant during exercise than at rest. 相似文献
10.
Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt Koyanagi Harada disease 总被引:4,自引:0,他引:4
Sugita Sunao; Sagawa Kimitaka; Mochizuki Manabu; Shichijo Shigeki; Itoh Kyogo 《International immunology》1996,8(5):799-803
The MART-1/Melan-A melanoma antigen recognized by the majorityof HLA-A2-restricted tumorinfiltrating lymphocytes is a selfantigen expressed on melanocytes and the retina. We have investigatedwhether Vogt–Koyanagi–Harada (VKH) disease and sympatheticophthalmia (SO), systemic inflammatory disorders affecting variousorgans containing melanocytes, are autoimmune diseases directedtoward the MART-1 antigen. In two of three patients with VKHdisease and one patient with SO, CD8+ T cell clones (TCC) fromintraocular fluid of HLA-A2+ patients lysed T2 cells when pulsedwith a HLA-A2-binding MART-1 peptide, but not a HLA-A2-bindingpMel-17 or tyrosinase peptide, in a HLA-A2-restricted manner.These CD8+ TCC lysed both melanocytes and melanoma cells ina HLA-A2-restricted manner. In addition, CD8+ TCC recognizinga HLA-A2-binding MART-1 peptide were also established from peripheralblood mononuclear cells of a patient with VKH disease. In contrast,either CD4+ TCC from these patients or CD8+ TCC from the intraocularfluid of HLA-A2+ patients with uveitis associated with Behcet'sdisease or HTLV-I uveitis did not show this cytotoxicity. Theresults demonstrate that the MART-1 peptide-specific cytotoxicT lymphocytes lyse melanocytes in the eye of patients with VKHdisease or SO, suggesting that these diseases are autoimmunediseases directed toward the MART-1 antigen in HLA-A2+ patients. 相似文献