全文获取类型
收费全文 | 286篇 |
免费 | 16篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 2篇 |
基础医学 | 68篇 |
口腔科学 | 2篇 |
临床医学 | 36篇 |
内科学 | 50篇 |
皮肤病学 | 1篇 |
神经病学 | 22篇 |
特种医学 | 10篇 |
外科学 | 35篇 |
综合类 | 6篇 |
预防医学 | 7篇 |
眼科学 | 1篇 |
药学 | 36篇 |
肿瘤学 | 27篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 7篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 3篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 7篇 |
2014年 | 17篇 |
2013年 | 9篇 |
2012年 | 27篇 |
2011年 | 32篇 |
2010年 | 20篇 |
2009年 | 14篇 |
2008年 | 21篇 |
2007年 | 13篇 |
2006年 | 12篇 |
2005年 | 19篇 |
2004年 | 21篇 |
2003年 | 20篇 |
2002年 | 16篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 7篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1988年 | 2篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有304条查询结果,搜索用时 0 毫秒
1.
Job satisfaction in Japanese nurses 总被引:5,自引:0,他引:5
Mineko Yamashita PhD RN 《Journal of advanced nursing》1995,22(1):158-164
This study investigated job satisfaction among nurses in Japan The instrument for measuring occupational satisfaction of hospital nurses developed by Stamps and her associates was used Initial items were reviewed by content experts who were familiar with measurement of work satisfaction among health professionals and nursing practice in Japan Based on the item analysis in the cultural context, several items were reworded or eliminated from the original version Twenty-five items were retained and translated into English by bilingual professionals The questionnaire was administered to 613 nurses Practising in a large, acute-care hospital in a southern part of Japan The results from testing psychometric properties of the translated version of the instrument were satisfactory It may be concluded that nurses in the study were not satisfied but not dissatisfied either On all items, they showed relatively strong commitment to their work However, extrinsic factors such as having little opportunities for promotion or less favourable working conditions appeared to negatively influence job satisfaction in the study The findings support the dual factor theory of Herzberg and also Maslow's theory Considering the lowest scored item, little opportunities for promotion, which reflects the employment system in Japan, administrators, who are usually male medical practitioners, should be made aware of a need for creating clinical ladder opportunities for nurses who would be promoted based on a merit system, instead of the current practice of a seniority system 相似文献
2.
Mineko Terao Dimitrina Pravtcheva Frank H. Ruddle Beatrice Mintz 《Somatic Cell and Molecular Genetics》1988,14(2):211-215
The gene encoding the mouse placental alkaline phosphatase (ALP; orthophosphoric-monoester phosphohydrolase, alkaline optimum, EC 3.1.3.1) is mapped to chromosome 4, based on Southern blot hybridization of the mouse cDNA with DNAs from mouse-Chinese hamster somatic cell hybrids. This assignment is consistent with the genetic analysis of theAkp-2 locus, which is responsible for the genetic variation of alkaline phosphatase enzyme in placenta as well as in liver, kidney, and bone. 相似文献
3.
Ghrelin Induces Fasted Motor Activity of the Gastrointestinal Tract in Conscious Fed Rats 总被引:15,自引:1,他引:15
Kazunori Fujino Akio Inui† Akihiro Asakawa† Naoki Kihara Masaki Fujimura Mineko Fujimiya‡ 《The Journal of physiology》2003,550(1):227-240
Ghrelin is a newly discovered orexigenic peptide originating from the stomach. However, its action in regulating the fed and fasted motor activity of the digestive tract is not fully understood. In the present study, we examined the effects of intracerebroventricular ( i.c.v. ) and intravenous ( i.v. ) injection of ghrelin on the physiological fed and fasted motor activities in the stomach and duodenum of freely moving conscious rats. i.c.v. and i.v. injection of ghrelin induced fasted motor activity in the duodenum in normal fed rats, while i.v. injection of ghrelin induced fasted motor activity in both the stomach and duodenum in vagotomized rats. The effects of i.c.v. and i.v. injected ghrelin were blocked by growth hormone secretagogue receptor (GHS-R) antagonist given by the same route and also blocked by immunoneutralization of neuropeptide Y (NPY) in the brain. The effects of i.v. injected ghrelin were not altered by i.c.v. injection of GHS-R antagonist in vagotomized rats. Injection of GHS-R antagonist blocked the fasted motor activity in both the stomach and duodenum in vagotomized rats but did not affect the fasted motor activity in normal rats. Low intragastric pH inhibited the effect of ghrelin. The present results indicate that ghrelin is involved in regulation of fasted motor activity in the stomach and duodenum. Peripheral ghrelin may induce the fasted motor activity by activating the NPY neurons in the brain, probably through ghrelin receptors on vagal afferent neurons. Once the brain mechanism is eliminated by truncal vagotomy, ghrelin might be primarily involved in the regulation of fasted motor activity through ghrelin receptors on the stomach and duodenum. The action of ghrelin to induce fasted motor activity is strongly affected by intragastric pH; low pH inhibits the action. 相似文献
4.
Shinichiro Nanko Akira Ueki Mineko Hattori Xiao Y. Dai Tsukasa Sasaki Rimmei Fukuda Kazuhiko Ikeda Hajime Kazamatsuri 《American journal of medical genetics. Part A》1994,54(4):361-364
Parkinson's disease is thought to be caused by a combination of unknown environmental, genetic, and degenerative factors. Evidence from necropsy brain samples and pharmacokinetics suggests involvement of dopamine receptors in the pathogenesis or pathophysiology of Parkinson's disease. Genetic association studies between Parkinson's disease and dopamine D2, D3 and D4 receptor gene polymorphisms were conducted. The polymorphism was examined in 71 patients with Parkinson's disease and 90 controls. There were no significant differences between two groups in allele frequencies at the D2, D3, and D4 dopamine receptor loci. Our findings do not support the hypothesis that susceptibility to Parkinson's disease is associated with the dopamine receptor polymorphisms examined. © 1994 Wiley-Liss, Inc. 相似文献
5.
Maekawa M; Sugano K; Kashiwabara H; Ushiama M; Fujita S; Ohkura H; Kakizoe T 《Japanese journal of clinical oncology》1998,28(6):383-387
BACKGROUND: Ornithine decarboxylase (ODC; EC 4.1.1.17) is the first
rate-limiting enzyme in the biosynthesis of polyamines. ODC protein has a
characteristic amino acid sequence, the PEST sequence, which is related to
the enzyme's rapid degradation. ODC cDNA prepared from human hepatoma
tissues has been reported to show nonsense or missense mutations. METHODS:
We examined somatic mutations of ODC cDNA by RT-PCR-SSCP analysis and mRNA
expressions by RT-PCR in 50 colorectal cancer tissues to investigate the
involvement of ODC gene alterations in colorectal cancers. RESULTS:
Increased expression of the ODC gene was observed in 36 cases (86%) out of
the 42 examined by RT-PCR. In one case, a missense mutation was found in
the cancer tissue but not in normal mucosa. The missense mutation from Asp
to Asn at codon 424, in the PEST region, possibly stabilizes the ODC
protein. In colorectal cancer, replication error and a germline mutation in
hMSH2 gene were observed. CONCLUSIONS: The missense mutation at codon 424
is speculated to be a cause of stabilization and a passenger mutation owing
to the mutator phenotype. Since only one of 50 colorectal cancers exhibited
a missense mutation of the ODC gene, mutations in ODC gene are not frequent
in colorectal cancer. The increased expression of the ODC gene was noted in
86% of colorectal cancer tissues by RT-PCR, however, it was not due to
point mutations in ODC coding exons.
相似文献
6.
Jae Do Yang Kazuo Ishikawa Hong Pil Hwang Dong-Eun Park Ji Soo Song Mineko Fujimiya Gen Murakami Baik Hwan Cho 《Surgical and radiologic anatomy : SRA》2013,35(5):403-410
To determine the fascial configuration between the superior mesenteric artery and vein and the posterior aspect of the pancreas, we examined histological sections of 10 elderly donated cadavers without pathology in the abdomen. The retropancreatic fascia was absent along the pancreatic parenchyma facing the artery and vein. Abundant nerves along the artery were separated from the pancreas by loose tissue almost 10 mm in thickness. In addition, anterior renal fasciae facing the pancreatic body were not evident in these specimens, possibly due to the degeneration of the left adrenal gland with age. Thus, a definite renal fascia was restricted on the lateral and posterior sides of the left kidney. These findings suggest that interactions between a pancreatic tumor and nerves would require migration of cancer cells over a long distance. Conversely, attachment of the enlarged tumor mass to the nerves may be necessary for the invasion. The anterior renal fascia may fuse with the retropancreatic fascia. 相似文献
7.
Kodesho Taiki Taniguchi Keigo Kato Takuya Mizoguchi Shougo Yamakoshi Yoshiki Watanabe Kota Fujimiya Mineko Katayose Masaki 《Journal of Medical Ultrasonics》2021,48(2):115-121
Journal of Medical Ultrasonics - Estimation of muscle passive force from elasticity using shear wave elastography (SWE) has been reported. However, the relationship between the elasticity and... 相似文献
8.
9.
This study describes the clustering patterns of several lifestyle-related factors in urban Japanese subjects. The effect of aging on these patterns was also investigated. Data of 8 factors that included body mass index (BMI), blood pressure (BP), fasting plasma glucose (FPG), serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLc), gamma-glutamyl-transferase (GGT), and cigarette smoking were analyzed for 12,525 individuals (4,591 men and 7,934 women) aged either 40, 50, or 60 years. Factor analysis showed eight factors clustered into 3 unrelated groups. BMI and BP were excluded in subjects aged 60 years. Our data showed that the effect of obesity on the prevalence of type 2 diabetes mellitus was age dependent. In spite of the established inverse relationship between TG and HDLc, we found that TG had an association with GGT. These results indicated that aging may have a major influence on the expression of multiple risk factors. The influence of BMI on the lifestyle-related factors appeared to be mostly expressed in younger people, while these factors appeared to be independent of BMI at age 60. 相似文献
10.
Miyasaka K Ichikawa M Momose K Araki A Kobayashi M Ichimaru Y Funakoshi A 《Archives of gerontology and geriatrics》2004,39(1):83-91
Although the idea that energy metabolism of rats decreases with age has been widely accepted, few studies with regard to the diurnal rhythm of energy expenditure have been reported. Whether age alone altered the diurnal rhythm of energy expenditure was examined in Sprague-Dawley (SD) rats. The same determination was conducted in Otsuka Long Evans Tokushima Fatty (OLETF) rats to examine the effect of insulin resistance and diabetes. OLETF rats were developed as a model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. The characteristic features of OLETF rats are late onset of hyperglycemia at about 18 weeks of age, followed by insulin deficiency at about 65 weeks. Age-associated changes in diurnal rhythm of energy expenditure were not observed in SD rats. In OLETF rats, the diurnal rhythm of energy expenditure with two peaks was observed at 8 weeks of age, while these two peaks disappeared at 24 weeks of age (with NIDDM). Then, the pattern of diurnal rhythm at 44 weeks of age (with advanced NIDDM) was resembled to that of 62 weeks of age (with insulin deficiency). In conclusion, we clarified the changes in diurnal rhythm of energy expenditure associated with the progress of diabetes, while age alone did not alter the diurnal rhythm. 相似文献