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排序方式: 共有70条查询结果,搜索用时 31 毫秒
1.
Isolation,Replication and Polyhedrin Gene Sequence of an Israeli Helicoverpa Armigera Single Nucleopolyhedrovirus 总被引:1,自引:0,他引:1
A local strain of Helicoverpa armigera baculovirus was isolated from infected H. armigera larvae. Infectivity to Helicoverpa
cells, restriction enzyme analysis and electron microscopy allowed its identification as a single embedded nucleopolyhedrovirus,
designated HaSNPV-IS. Analysis of DNA replication, protein synthesis and polyhedrin expression in HaSNPV-infected cells located
the late and very late phases of the viral cycle at 24 and 48 h after infection, respectively. The viral polyhedrin gene was
isolated and characterized. It encoded for a polypeptide of 246 amino acid residues. A 32 kDa polypeptide was identified by
immunoblot analysis using anti-polyhedrin antiserum. The HaSNPV-IS polyhedrin DNA sequence revealed 99.4% of homology to the
HzSNPV polyhedrin. The availability of this efficient replication system and the above knowledge paves the way to future genetic
engineering of the HaSNPV.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
2.
Paulette Bernd Michael D. Gershon Eladio A. Nunez Hadassah Tamir 《Anatomical record (Hoboken, N.J. : 2007)》1979,193(2):257-267
A highly specific serotonin binding protein (SBP) has been found in serotonergic neurons in both brain and gut. This protein has an extremely high affinity for serotonin and may be a storage protein. Serotonin is found in many endocrine cells, including parafollicular cells of the sheep thyroid, as well as in neurons. SBP is also present in sheep thyroid. The present study was done to localize the protein in the gland. Thyroid glands were divided into five segments. Concentrations of serotonin and SBP, as well as parafollicular cell volume were measured in each. Serotonin was assayed by enzymatic conversion to melatonin using tritiated S-adenosylmethionine. SBP was assayed by molecular sieve chromatography on sephadex G-50. The relative volume of parafollicular cells was obtained by stereological analysis of electron micrographs. Experiments were also done to demonstrate these cells by histofluorescence and radioautography following incubation with tritiated 5-hydroxytryptophan. Good correlations were found between serotonin and SBP concentrations, and parafollicular cell volume. These peaked in the rostro-central portion of the gland and were minimal at the poles. We conclude that thyroid SBP is probably localized in parafollicular cells. 相似文献
3.
Galit Saar Yoram Zilberman Hadassah Shinar Keren Keinan‐Adamsky Gadi Pelled Dan Gazit Gil Navon 《NMR in biomedicine》2010,23(6):554-562
In order to investigate intervertebral disc (IVD) degeneration and repair, a quantitative non‐invasive tool is needed. Various MRI methods including qCPMG, which yields dipolar echo relaxation time (TDE), magnetization transfer contrast (MTC), and 1H and 2H double quantum filtered (DQF) MRI were used in the present work to monitor changes in rat IVD after ablation of the nucleus pulposus (NP), serving as a model of severe IVD degeneration. In the intact IVD, a clear distinction between the annulus fibrosus (AF) and the NP is obtained on T2 and TDE weighted images as well as on MTC maps, reflecting the high concentration of ordered collagen fibers in the AF. After ablation of the NP, the distinction between the compartments is lost. T2 and TDE relaxation times are short throughout the disc and MTC is high. 1H and 2H DQF signal, which in intact discs is obtained only for the AF, is now observable throughout the tissue. These results indicate that after ablation, there is an ingression of collagen fibers from the AF into the area that was previously occupied by the NP, as was confirmed by histology. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
4.
5.
Hadassah LeBow MD Medad Schiller MD Gerald Caplan MD Drora Selinger MD 《Child psychiatry and human development》1983,13(3):180-188
This paper deals with the techniques of integrating a child psychiatrist into a pediatric-surgical service. The use of executive meetings between the heads of both departments and the psychiatrist allowed for immediate clarification of misunderstandings and the formalization of decisions into administrative procedures. The special technique whereby the surgeon, on the basis of psychiatric information, acts as the spokesman for the joint psychiatric-surgical decision is discussed. The conceptualization of severe physical illness with rapid hospitalization as a crisis, allowed us to apply the crisis intervention theory as the basis for remedial intervention. 相似文献
6.
Boost radiotherapy in young women with ductal carcinoma in situ: a multicentre, retrospective study of the Rare Cancer Network 总被引:3,自引:0,他引:3
Omlin A Amichetti M Azria D Cole BF Fourneret P Poortmans P Naehrig D Miller RC Krengli M Gutierrez Miguelez C Morgan D Goldberg H Scandolaro L Gastelblum P Ozsahin M Dohr D Christie D Oppitz U Abacioglu U Gruber G 《The lancet oncology》2006,7(8):652-656
BACKGROUND: Outcome data in young women with ductal carcinoma in situ (DCIS) are rare. The benefits of boost radiotherapy in this group are also unknown. We aimed to assess the effect of boost radiotherapy in young patients with DCIS. METHODS: We included 373 women from 18 institutions who met the following inclusion criteria: having tumour status Tis and nodal status (N)0, age 45 years or younger at diagnosis, and having had breast-conserving surgery. 57 (15%) patients had no radiotherapy after surgery, 166 (45%) had radiotherapy without boost (median dose 50 Gy [range 40-60]), and 150 (40%) had radiotherapy with boost (60 Gy [53-76]). The primary outcome was local relapse-free survival. FINDINGS: Median follow-up was 72 months (range 1-281). 55 (15%) patients had local relapse. Local relapse-free survival at 10 years was 46% (95% CI 24-67) for patients given no radiotherapy, 72% (61-83) for those given radiotherapy without boost, and 86% (78-93) for those given radiotherapy and boost (difference between all three groups, p<0.0001). Age, margin status, and radiotherapy dose were significant predictors of local relapse-free survival. Compared with patients who had no radiotherapy, those who had radiotherapy had a decreased risk of local relapse (without boost, hazard ratio 0.33 [95% CI 0.16-0.71], p=0.004; with boost, 0.15 [0.06-0.36], p<0.0001). INTERPRETATION: In the absence of randomised trials, boost radiotherapy should be considered in addition to surgery for breast-conserving treatment for DCIS. 相似文献
7.
Gerald Caplan Hadassah LeBow Miriam Gavarin Josef Stelzer 《The journal of primary prevention》1981,2(1):40-49
Four patterns of child psychiatrist cooperation which have implications for prevention are described: Autonomous Psychiatric Unit; Consultation; Collaboration; and Executive Partnership. These represent a gradient of increasing participation of psychiatrists inside the other department in the treatment of patients, in case responsibility, and in administrative authority over the service system.The authors are affiliated with the Department of Child Psychiatry, Hadassah-Hebrew University Hospitals, Jerusalem. 相似文献
8.
Smith-Norowitz TA Drew H Norowitz HM Nowakowski M Bluth EF Durkin HG Bluth MH 《Annals of clinical and laboratory science》2008,38(2):168-173
Breast milk is a complex fluid, rich in nutrients and non-nutritional bioactive components, including antimicrobial factors, immunoglobulins, cytokines, and anti-inflammatory substances. Although IgE is implicated in viral immunity, its role in breast milk in parvovirus B19 immunity has not been studied. Total immunoglobulin levels of IgE, IgG, and IgE anti-parvovirus B19 antibodies were determined by ELISA and Western blot analysis in breast milk and in sera from a mother and her nursing infant (female, 10 mo). For specific IgE protein determination, breast milk was fractionated by chromatography on G-100 Sephadex; 3 peaks were collected and separated by SDS PAGE. The levels of total IgE in breast milk and its fractions were low (<2.4 ng/ml), and those of maternal and infant serum were negligible (18 and 4.3 IU/ml, respectively). Nevertheless, the breast milk and maternal and infant sera contained IgE anti-parvovirus B19 antibodies, even though the infant was never infected with parvovirus B19. Total serum levels of maternal IgG were within the normal range and those of infant IgG were low (473 mg/dl); total IgG in breast milk was not determined. Maternal serum contained some detectable IgG anti-parvovirus antibodies that were not present in infant serum or breast milk. Total maternal and infant serum levels of IgM and IgA were within the normal ranges. The presence of IgE anti-parvovirus B19 antibodies in breast milk suggests that IgE anti-viral antibodies are transmitted in breast milk and may provide protective responses in nursing children. 相似文献
9.
Hadassah Goldberg Moshe E. Stein Ofer Ben-Itzhak David Duek Anna Ravkin Diana Gaitini 《Journal of surgical oncology》1998,67(3):186-189
Follicular thyroid carcinoma, initially presenting as spinal cord compression due to metastatic lesions, is a less reported event. We present two cases of well-differentiated thyroid carcinoma that led to spinal cord compression. A thorough search of the literature revealed only five similar cases. We summarize the clinical characteristics of these cases, the therapeutic measures used, their outcome, and the prognosis. J. Surg. Oncol. 1998;67:186–189. © 1998 Wiley-Liss, Inc. 相似文献
10.
Hadassah Shinar Yoshiteru Seo Kazuya Ikoma Yoshiaki Kusaka Uzi Eliav Gil Navon 《Magnetic resonance in medicine》2002,48(2):322-330
The one-dimensional (2)H double quantum filtered (DQF) spectroscopic imaging technique was used to study the orientation of collagen fibers in articular cartilage. The method detects only water molecules in anisotropic environments, which in cartilage is caused by their interaction with the collagen fibers. A large quadrupolar splitting was observed in the calcified zone and a smaller splitting in the radial zone. In the transitional zone the splitting was not resolved and a small splitting was again detected in the superficial zone. From measurements performed at two orientations of the plug relative to the magnetic field it was deduced that in the calcified and radial zones the fibers are oriented perpendicular to the bone, bending at the transitional zone and flattening at the superficial zone. The effect of load applied to the cartilage-bone plug was monitored by the same technique. At low loads there is a small decrease in the quadrupolar splitting in the calcified zone, a marked decrease in the radial zone, and an increase of the splitting accompanied by a thickening of the superficial zone. Under high loads, while the thickening and the splitting of the superficial zone further increase, the splitting in the radial and calcified zones completely collapse. Pressure-induced changes in the thickness of the surface zone indicate flattening of the collagen fibers near the surface. The marked collapse of the splitting near the bone at high pressures may result from crimping of the collagen fibers. 相似文献