全文获取类型
收费全文 | 802篇 |
免费 | 47篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 41篇 |
妇产科学 | 7篇 |
基础医学 | 134篇 |
口腔科学 | 18篇 |
临床医学 | 85篇 |
内科学 | 138篇 |
皮肤病学 | 26篇 |
神经病学 | 38篇 |
特种医学 | 142篇 |
外科学 | 76篇 |
综合类 | 12篇 |
预防医学 | 51篇 |
眼科学 | 3篇 |
药学 | 34篇 |
肿瘤学 | 61篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 16篇 |
2020年 | 5篇 |
2019年 | 4篇 |
2017年 | 9篇 |
2016年 | 12篇 |
2015年 | 19篇 |
2014年 | 14篇 |
2013年 | 28篇 |
2012年 | 19篇 |
2011年 | 21篇 |
2010年 | 36篇 |
2009年 | 38篇 |
2008年 | 23篇 |
2007年 | 33篇 |
2006年 | 29篇 |
2005年 | 24篇 |
2004年 | 31篇 |
2003年 | 22篇 |
2002年 | 17篇 |
2001年 | 18篇 |
2000年 | 15篇 |
1999年 | 18篇 |
1998年 | 37篇 |
1997年 | 43篇 |
1996年 | 32篇 |
1995年 | 33篇 |
1994年 | 14篇 |
1993年 | 20篇 |
1992年 | 9篇 |
1991年 | 8篇 |
1990年 | 12篇 |
1989年 | 16篇 |
1988年 | 23篇 |
1987年 | 22篇 |
1986年 | 12篇 |
1985年 | 16篇 |
1984年 | 11篇 |
1983年 | 8篇 |
1982年 | 13篇 |
1981年 | 6篇 |
1980年 | 9篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1976年 | 8篇 |
1975年 | 10篇 |
1972年 | 5篇 |
1971年 | 4篇 |
1965年 | 5篇 |
排序方式: 共有871条查询结果,搜索用时 8 毫秒
1.
2.
3.
4.
R Bachmann B Genin P Bugmann D Belli S Hanquinet P Liniger C Le Coultre 《Zeitschrift für Kinderchirurgie》2003,13(4):280-284
Although benign, hepatic haemangioendotheliomas (HHE) are rare vascular tumours of the infant which have a high mortality rate secondary to high output congestive heart failure. The management of these tumours is still controversial and none of the different medical or surgical options has been unanimously accepted. We report the case of a neonate with congestive heart failure (CHF) due to a localized HHE, treated successfully by selective ligation of the left hepatic artery branch irrigating the tumour, under perioperative ultrasound Doppler control. A review of the literature showed 35 cases of HHE treated by hepatic artery ligation (HAL) with a survival rate of 80 %. 相似文献
5.
6.
Polycystic kidney disease is an autosomal dominant disease that may be associated with cystic disease of the liver. In women, the cysts may develop early and be more troublesome than in men. Cystadenocarcinoma of the pancreas is uncommon, comprising 1% of primary pancreatic malignancies. This case report is the first to describe a familial association between polycystic kidney disease and cystadenocarcinoma of the pancreas and liver in the English medical literature. A patient with autosomal dominant polycystic kidney disease (ADPKD) and multiple hepatic cysts developed cystadenocarcinoma of the pancreas with multiple malignant liver cysts. The patient's mother, sister, and niece had ADPKD, and the patient's sister also died of pancreatic cystadenocarcinoma. We believe that the development of these two disease entities in which the primary pathology is cyst formation has a genetic association. (Gastroenterology 1997 Jun;112(6):2104-7) 相似文献
7.
8.
Glucokinase and cytosolic phosphoenolpyruvate carboxykinase (GTP) in the human liver. Regulation of gene expression in cultured hepatocytes. 总被引:3,自引:1,他引:2 下载免费PDF全文
P B Iynedjian S Marie A Gjinovci B Genin S P Deng L Buhler P Morel G Mentha 《The Journal of clinical investigation》1995,95(5):1966-1973
Glucokinase and phosphoenolpyruvate carboxykinase are key enzymes of glucose metabolism in the rat liver. The former is considered to be instrumental in regulating glucose hepatic release/uptake according to the glycaemia level, and cytosolic phosphoenolpyruvate carboxykinase is a major flux-generating enzyme for gluconeogenesis. The level of expression of both enzymes and the regulation of their mRNAs in the human liver cell were investigated. Surgical biopsies of liver from patients undergoing partial hepatectomies and parenchymal hepatocytes derived from the biopsies were used to assay glucokinase, hexokinase and phosphoenolpyruvate carboxykinase activities. Hepatocytes were placed in culture and the actions of insulin, glucagon and cAMP on glucokinase and phosphoenolpyruvate carboxykinase mRNAs were studied. The main results are: (a) glucokinase accounts for 95% of the glucose phosphorylation activity of human hepatocytes, although this fact is masked in assays of total liver tissue; (b) glucokinase activity is set at a lower level in human hepatocytes than in rat hepatocytes, and vice-versa for the gluconeogenic enzyme phosphoenolpyruvate carboxykinase; and (c) as previously shown in rat liver, glucokinase and phosphoenolpyruvate carboxykinase mRNAs are regulated in a reciprocal fashion in human hepatocytes, insulin inducing the first enzyme and repressing the latter, whereas glucagon has opposite effects. These data have interesting implications with respect to metabolic regulation and intracellular hormone signaling in the human liver. 相似文献
9.
10.
Diedhiou A Genin P Terris B Sauvanet A Belghiti J Degott C 《Annales de pathologie》2002,22(2):134-136
Undifferentiated embryonal sarcoma of the liver is rare. It is usually observed in children and adolescents. We report one case of embryonal sarcoma of the liver arising in patient without any antecedent. The only symptom was right scapular pain. The liver scan showed a multicystic lesion suspicious for infectious origin or a tumor. Serologies for ecchinococcus, schistosomiasis and brucellosis were negative. The treatment was a right hepatectomy. On gross examination, the tumor was unencapsulated, multicystic and contained large areas of necrosis admixed with gelatinous areas. Microscopically, there were epithelioid and spindle tumor cells in a myxo?d stroma. Lipoblastic-like or rhabdomyoblastic-like, giant cells and PAS positive hyaline globules in the cell cytoplasm were present. The tumor cells expressed vimentin, cytokeratin (KL1), alpha-1-antitrypsin and smooth muscle actin. This observation shows that embryonal sarcoma of the liver may develop in adult patients and should be taken into consideration in any differential diagnosis of cystic hepatic tumor. 相似文献