全文获取类型
收费全文 | 224篇 |
免费 | 30篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 2篇 |
妇产科学 | 5篇 |
基础医学 | 26篇 |
口腔科学 | 8篇 |
临床医学 | 35篇 |
内科学 | 53篇 |
皮肤病学 | 13篇 |
神经病学 | 13篇 |
特种医学 | 14篇 |
外科学 | 38篇 |
综合类 | 3篇 |
预防医学 | 7篇 |
眼科学 | 3篇 |
药学 | 21篇 |
中国医学 | 2篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 6篇 |
2022年 | 16篇 |
2021年 | 14篇 |
2020年 | 19篇 |
2019年 | 22篇 |
2018年 | 14篇 |
2017年 | 9篇 |
2016年 | 12篇 |
2015年 | 14篇 |
2014年 | 11篇 |
2013年 | 12篇 |
2012年 | 29篇 |
2011年 | 23篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 8篇 |
2007年 | 8篇 |
2006年 | 5篇 |
2005年 | 3篇 |
2004年 | 4篇 |
2003年 | 5篇 |
2002年 | 4篇 |
1999年 | 1篇 |
1998年 | 1篇 |
排序方式: 共有255条查询结果,搜索用时 31 毫秒
1.
2.
Mitral valve resistance determines hemodynamic consequences of severe rheumatic mitral stenosis and immediate outcomes of percutaneous valvuloplasty 下载免费PDF全文
3.
Nasrin Mirzaei Farkhondeh Poursina Sharareh Moghim Niloufar Rashidi 《Critical reviews in microbiology》2017,43(5):631-650
Helicobacter pylori has grown to colonize inside the stomach of nearly half of the world’s population, turning into the most prevalent infections in the universe. Medical care failures noticeably confirm the need for a vaccine to hinder or deal with H. pylori. This review is planned to discuss the most known factors as a vaccine candidate, including single (AhpC, BG, CagA, KatA, Fla, Hsp, HWC, Lpp, LPS, NAP, OMP, OMV, SOD, Tpx, Urease, VacA) and multi-component vaccines. Many promising results in the field of single and multivalent vaccine can be seen, but there is no satisfactory outcome and neither a prophylactic nor a therapeutic vaccine to treat or eradicate the infection in human has been acquired. Hence, selecting suitable antigen is an important factor as an appropriate adjuvant. Taken all together, the development of efficient anti-H. pylori vaccines relies on the fully understanding of the interactions between H. pylori and its host immune system. Therefore, more work should be done on epitope mapping, analysis of molecular structure, and determination of the antigen determinant region as well due to design a vaccine, preferably a multi-component vaccine to elicit specific CD4 T-cell responses that are required for H. pylori vaccine efficacy. 相似文献
4.
5.
6.
Moreau Anthony Ego Amedee Vandergheynst Frederic Taccone Fabio Silvio Sadeghi Niloufar Montesinos Isabel Gaspard Nicolas Gorham Julie 《Journal of neurology》2021,268(5):1592-1594
Journal of Neurology - 相似文献
7.
Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population 下载免费PDF全文
Niloufar Sadat MiriPayam SaadatAbbas AzadmehrMorteza OladnabiAbdolreza Daraei 《Iranian journal of immunology : IJI》2020,17(4):313-323
Background: Neuroinflammation and immunopathology in Parkinson's disease (PD) are believed to be associated with genetic and environmental factors. Objective: We conducted the current study to evaluate the Toll-like receptors (TLR4 and TLR9) genes polymorphism in patients with Parkinson's disease in northern Iran. Methods: We extracted DNA from peripheral blood samples of 100 sporadic cases of Parkinson's disease and 100 healthy-matched controls with the mean age of 69.98 and 71.94 years, respectively. Subsequently, single-nucleotide polymorphisms (SNPs) of TLR4 and TLR9 were genotyped using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR). Results were confirmed employing Sanger sequencing. For the analysis of our data, we used SNPStats and SPSS 22 software. Results: Our findings indicated that the allele distribution for rs352140 of TLR9 gene was significantly different in the PD group compared with the healthy controls (p=0.02). Moreover, rs352140 T allele was observed to be correlated with PD reduced risk (TT + TC vs. CC). The dominant rs352140 model was approved as the most acceptable inheritance model for fitting the data (OR 0.41, 95% CI 0.23-0.75, p=0.0031). Additionally, haplotype analysis revealed a significant correlation between TLR9 polymorphisms and Parkinson's disease. Conclusion: The results of this study indicated that rs352140T of TLR9 gene was a protective factor in Parkinson's disease. Furthermore, this SNP could be regarded as a prognostic factor. However, this conclusion should be confirmed by further investigations. 相似文献
8.
9.
Fatemeh Gholami Sajjad Moradi Niloufar Rasaei Neda Soveid Leila Setayesh Khadijeh Mirzaei 《Journal of neurology》2022,269(1):205-216
Journal of Neurology - The Present study was conducted to systematically review the effect of the melatonin on sleep quality. We summarized evidence from randomized clinical trials (RCTs) that... 相似文献
10.
Farzane Hendudari Abbas Piryaei Seyedeh-Nafiseh Hassani Hasan Darbandi Mohammad Bayat 《Lasers in medical science》2016,31(4):749-757
Low-level laser therapy (LLLT) exhibited biostimulatory effects on fibroblasts viability. Secretomes can be administered to culture mediums by using bone marrow mesenchymal stem cells conditioned medium (BM-MSCs CM). This study investigated the combined effects of LLLT and human bone marrow mesenchymal stem cell conditioned medium (hBM-MSCs CM) on the cellular viability of human dermal fibroblasts (HDFs), which was cultured in a high-glucose (HG) concentration medium. The HDFs were cultured either in a concentration of physiologic (normal) glucose (NG; 5.5 mM/l) or in HG media (15 mM/l) for 4 days. LLLT was performed with a continuous-wave helium-neon laser (632.8 nm, power density of 0.00185 W/cm2 and energy densities of 0.5, 1, and 2 J/cm2). About 10 % of hBM-MSCs CM was added to the HG HDF culture medium. The viability of HDFs was evaluated using dimethylthiazol-diphenyltetrazolium bromide (MTT) assay. A significantly higher cell viability was observed when laser of either 0.5 or 1 J/cm2 was used to treat HG HDFs, compared to the control groups. The cellular viability of HG-treated HDFs was significantly lower compared to the LLLT?+?HG HDFs, hBM-MSCs CM-treated HG HDFs, and LLLT?+?hBM-MSCs CM-treated HG HDFs. In conclusion, hBM-MSCs CM or LLLT alone increased the survival of HG HDFs cells. However, the combination of hBM-MSCs CM and LLLT improved these results in comparison to the conditioned medium. 相似文献