全文获取类型
收费全文 | 2662篇 |
免费 | 149篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 65篇 |
妇产科学 | 55篇 |
基础医学 | 380篇 |
口腔科学 | 44篇 |
临床医学 | 211篇 |
内科学 | 574篇 |
皮肤病学 | 105篇 |
神经病学 | 279篇 |
特种医学 | 113篇 |
外科学 | 340篇 |
综合类 | 22篇 |
一般理论 | 6篇 |
预防医学 | 150篇 |
眼科学 | 42篇 |
药学 | 251篇 |
中国医学 | 3篇 |
肿瘤学 | 176篇 |
出版年
2023年 | 14篇 |
2022年 | 23篇 |
2021年 | 34篇 |
2020年 | 27篇 |
2019年 | 52篇 |
2018年 | 57篇 |
2017年 | 29篇 |
2016年 | 45篇 |
2015年 | 54篇 |
2014年 | 78篇 |
2013年 | 106篇 |
2012年 | 151篇 |
2011年 | 164篇 |
2010年 | 91篇 |
2009年 | 83篇 |
2008年 | 145篇 |
2007年 | 118篇 |
2006年 | 138篇 |
2005年 | 127篇 |
2004年 | 119篇 |
2003年 | 93篇 |
2002年 | 126篇 |
2001年 | 69篇 |
2000年 | 63篇 |
1999年 | 62篇 |
1998年 | 38篇 |
1997年 | 27篇 |
1996年 | 27篇 |
1994年 | 23篇 |
1993年 | 22篇 |
1992年 | 44篇 |
1991年 | 39篇 |
1990年 | 46篇 |
1989年 | 51篇 |
1988年 | 46篇 |
1987年 | 44篇 |
1986年 | 23篇 |
1985年 | 38篇 |
1984年 | 29篇 |
1983年 | 25篇 |
1982年 | 11篇 |
1981年 | 14篇 |
1979年 | 19篇 |
1978年 | 15篇 |
1977年 | 20篇 |
1976年 | 18篇 |
1975年 | 16篇 |
1974年 | 12篇 |
1973年 | 25篇 |
1972年 | 22篇 |
排序方式: 共有2837条查询结果,搜索用时 15 毫秒
1.
Bela Anand-Apte Jennifer R. Chao Ruchira Singh Heidi Stöhr 《Journal of neuroscience research》2019,97(1):88-97
Sorsby fundus dystrophy (SFD), an autosomal dominant, fully penetrant, degenerative disease of the macula, is manifested by symptoms of night blindness or sudden loss of visual acuity, usually in the third to fourth decades of life due to choroidal neovascularization (CNV). SFD is caused by specific mutations in the Tissue Inhibitor of Metalloproteinase-3, (TIMP3) gene. The predominant histo-pathological feature in the eyes of patients with SFD are confluent 20–30 m thick, amorphous deposits found between the basement membrane of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane. SFD is a rare disease but it has generated significant interest because it closely resembles the exudative or “wet” form of the more common age-related macular degeneration (AMD). In addition, in both SFD and AMD donor eyes, sub-retinal deposits have been shown to accumulate TIMP3 protein. Understanding the molecular functions of wild-type and mutant TIMP3 will provide significant insights into the patho-physiology of SFD and perhaps AMD. This review summarizes the current knowledge on TIMP3 and how mutations in TIMP3 cause SFD to provide insights into how we can study this disease going forward. Findings from these studies could have potential therapeutic implications for both SFD and AMD. 相似文献
2.
W. Nörenberg Ernst Schöffel Bela Szabo Klaus Starke 《Naunyn-Schmiedeberg's archives of pharmacology》1997,356(2):159-165
The aim of the study was to subclassify the soma-dendritic α2-autoreceptors in the locus coeruleus (LC) of the rat by means of antagonists. To this end, the frequency of spontaneous action
potentials was recorded extracellularly from single LC neurones in brain slices. The neurones fired spontaneously at an average
rate of 1 Hz. The selective α2-adrenoceptor agonist 5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline (UK 14,304) and noradrenaline decreased the action potential
discharge with IC50 values of 5 and 510 nM, respectively. The concentration-inhibition curves of UK 14,304 and noradrenaline were shifted to the
right by phentolamine (0.15 μM) and rauwolscine (0.15 μM) but not by prazosin (1 μM). Apparent K
d values of phentolamine were 17 nM (against UK 14,304) and 20 nM (against noradrenaline). Apparent K
d values of rauwolscine were 47 nM (against UK 14,304) and 70 nM (against noradrenaline). (+)-Oxaprotiline (1 μM) suppressed
the firing of the neurones within 10 to 33 min. In the continued presence of oxaprotiline, phentolamine and rauwolscine restored
firing with EC50 values of 120 and 250 nM, respectively. Prazosin (1 μM) again was ineffective. All three antagonist affinity estimates –
against UK 14,304, exogenous noradrenaline and endogenous noradrenaline (that accumulates in the extracellular space in the
presence of oxaprotiline) – yield an affinity order phentolamine > rauwolscine >> prazosin, prazosin being ineffective even
at a concentration of 1 μM. These findings identify the soma-dendritic α2-autoreceptors of the LC as the rat variant of the α2A/D-adrenoceptor, i.e. α2D. Not only presynaptic but also soma-dendritic α2-autoreceptors may at least predominantly be α2A/D throughout the nervous system.
Received: 3 March 1997 / Accepted: 21 April 1997 相似文献
3.
Fibrillary glomerulonephritis and immunotactoid glomerulopathy. 总被引:6,自引:0,他引:6
4.
Bela Prajapaty Bharat Shah 《Indian journal of otolaryngology and head and neck surgery》1997,49(4):391-393
The pyriform sinus fistula is rare congenital anomaly of either third or fourth branchial pouch, which most frequently presented itself by recurrent episodes of neck abscess for long time. Majority of patients with this anomaly presented with symptoms before 10 years and it is more common than has previously been commonly found on leftside (93%). Clinically high index of suspicion, cannulation of the tract under general anaesthesia, Direct laryngoscopy and fistulogram have freequently been successful in identifying the presence of these embryological remnants. Surgical exploration of sinus tract with its total excision, guided with cannula inside its lumen is the definitive treatment. 相似文献
5.
Bela Blasszauer 《The Hastings Center report》1986,16(3):25-27
Medical ethics in Hungary has finally moved beyond arguments over tipping and bribes to discussions of euthanasia, confidentiality, truth-telling and informed consent. Ethics committees have been formed at the local and national level, and medical schools are beginning to take seriously the systematic teaching of medical ethics. In some quarters, however, old attitudes persist. Among older doctors paternalism reigns supreme, and lawmakers continue to ignore international ethical guidelines. 相似文献
6.
An 89-year-old woman developed an acute carpal tunnel syndrome secondary to hemarthrosis associated with pigmented villonodular synovitis of the wrist. Pigmented villonodular synovitis is rare in a patient of this age and is an unusual cause of carpal tunnel syndrome. 相似文献
7.
Comminuted intraarticular fractures of the distal radius 总被引:1,自引:0,他引:1
The comminuted intraarticular fracture of the distal radius requires early, accurate reduction of the articular surfaces and sustained restoration of anatomic position. The most commonly employed methods are pins and plaster, external fixation, percutaneous pinning, and open reduction and internal fixation. There are pitfalls, advantages, and disadvantages inherent in each method. Careful preoperative analysis of individual patients and fractures determines the therapeutic options. 相似文献
8.
O. Reerink N. H. Mulder† B. G. Szabo W. J. Sluiter† T. Wiggers‡ A. H. H. Bongaerts§ G. A. P. Hospers† 《Colorectal disease》2004,6(6):406-417
Abstract The treatment options for primary irresectable rectal cancers are discussed. Assessment of tumour stage is the first step for an appropriate choice of treatment. Following a diagnosis of rectal cancer, a vast array of diagnostic procedures is available to determine its stage, and thereby its best treatment options. From the many (new) diagnostic options the merits and drawbacks are discussed. If a diagnosis of irresectability is made, further treatment options should include radiotherapy in most cases, some aspects of timing and application, i.e. intra-operative treatment are discussed. Chemotherapy options are manifold, the results are discussed and some new options are explored. 相似文献
9.
Comminuted distal radius fractures. 总被引:1,自引:0,他引:1
R M Szabo 《The Orthopedic clinics of North America》1992,23(1):1-6
Comminuted displaced fractures of the distal end of the radius pose a significant treatment challenge. The goal of treatment is to restore functional, painless motion of the wrist and fingers. Although satisfactory results correlate to a large extent with obtaining and maintaining normal anatomy, excessive distraction and a flexed wrist position with external fixation cause more harm than good, even if the anatomy is restored. 相似文献
10.
A Czeizel M Kovács P Kiss K Méhes L Szabo E Oláh G Kosztolányi G Szemere H Kovács G Fekete 《Genetic epidemiology》1988,5(3):183-202
A population-based study of 7,049 index patients with multiple congenital abnormalities (MCA) born in Hungary during 1973-1982 was organized by the Hungarian Center for Congenital Anomaly Control. All clinically recognized syndromes and associations which were submitted (2,049) were accepted without any further follow-up. New or supplementary information was requested in the case of unspecified MCA (320). A copy of detailed necropsy records was requested from pathologists in lethal cases (2,022). Following these steps, apparent but not true instances of MCA were excluded (399), and an attempt was made to assign as many of the remainder as possible in 17 well-delineated MCA entities (900). The living index patients with severe MCA were referred where possible to the regional centers for evaluation (864). One hundred and seventy entities were identified, and seven cases were excluded as not representing MCA. In the so-called 3,393 unidentified cases for which no diagnosis was possible, the component abnormalities were tabulated according to their number. The final count was 6,643 cases with MCA, which is equivalent to a birth prevalence of 4.0 per 1,000 total births, and to 10% of recorded cases with congenital anomalies. As a result of this program the proportion of recognized syndromes and associations among children with MCA increased from 29% to 47%. The accuracy of diagnoses has improved, e.g., the occurrence of unspecified cases decreased from 4.5% to 2%. As a result of this study, the number of chromosomal (1,700), Mendelian (557), and teratogenic (104) syndromes and associations (758) was considerably greater than the initial notifications indicated. 相似文献