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Yuh Hasegawa Akira Ezura Batbayar Nomintsetseg 《Odontology / the Society of the Nippon Dental University》2017,105(1):84-90
This study aimed to investigate the relationship between the morphological characteristics of maxillary incisors and the anterior occlusion. The study materials comprised dental casts and lateral cephalograms of 26 modern Mongolian females with Angle Class I normal occlusion (mean age, 21 years 5 months). Computed tomography (CT) images of the dental casts were taken with an X-ray micro-CT system (SMX-100CT, Shimadzu, Kyoto Japan). The thickness of the marginal ridges and incisal edges, and the overjet and overbite, was measured on the three-dimensional images of the dental casts. On the lateral cephalogram, maxillary incisor to sella–nasion plane angle (U1 to SN angle), maxillary incisor to nasion-point A plane distance (U1 to NA distance), mandibular incisor to nasion-point B plane distance (L1 to NB distance), incisor mandibular plane angle, and interincisal angle were measured by tracing the left incisors of the maxilla and mandible. Spearman’s single rank correlation coefficients were used to investigate any correlation between measurement items for each maxillary incisor. The thickness of the marginal ridges and incisal edges was positively correlated with the overbite. The thickness of the incisal edges was positively correlated with the irregularity index of the maxilla. There were significant negative correlations between overbite and U1 to SN angle, U1 to NA distance, and L1 to NB distance. Significant positive correlations were noted between the overbite and the overjet. In conclusion, there was no strong relationship between the morphological characteristics of maxillary incisors and the anterior occlusion. 相似文献
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During the course of evolution, animals encountered the harmful effects of fungi, which are strong pathogens. Therefore, they have developed powerful mechanisms to protect themselves against these fungal invaders. β-Glucans are glucose polymers of a linear β(1,3)-glucan backbone with β(1,6)-linked side chains. The immunostimulatory and antitumor activities of β-glucans have been reported; however, their mechanisms have only begun to be elucidated. Fungal and particulate β-glucans, despite their large size, can be taken up by the M cells of Peyer''s patches, and interact with macrophages or dendritic cells (DCs) and activate systemic immune responses to overcome the fungal infection. The sampled β-glucans function as pathogen-associated molecular patterns (PAMPs) and are recognized by pattern recognition receptors (PRRs) on innate immune cells. Dectin-1 receptor systems have been incorporated as the PRRs of β-glucans in the innate immune cells of higher animal systems, which function on the front line against fungal infection, and have been exploited in cancer treatments to enhance systemic immune function. Dectin-1 on macrophages and DCs performs dual functions: internalization of β-glucan-containing particles and transmittance of its signals into the nucleus. This review will depict in detail how the physicochemical nature of β-glucan contributes to its immunostimulating effect in hosts and the potential uses of β-glucan by elucidating the dectin-1 signal transduction pathway. The elucidation of β-glucan and its signaling pathway will undoubtedly open a new research area on its potential therapeutic applications, including as immunostimulants for antifungal and anti-cancer regimens. 相似文献
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Batbayal T Ishii Y Nomura Y Watanabe M Yasuko T Nakamura S 《Connective tissue research》2006,47(4):235-241
By immunohistochemistry, with or without chondroitinases, decorin was found to be distributed in the extracellular matrix of chorionic villi and amnia. The strength of staining intensified with increasing gestational age. Decorin was isolated from the placenta of 13- to 20-day-old pregnant rats and identified by Western blotting, using an antidecorin core protein antibody. The molecular weight of decorin is approximately 100 kDa, whereas the respective figures for the core protein treated with chondroitinase (chase) ABC and with chase B are approximately 40 kDa and 43 kDa. The difference in the molecular weight between the core protein with chase ABC and B suggests that the glycosaminoglycan (GAG)- base structure on the core protein was chondroitin sulfate (CS) without dermatan sulfate (DS). The decorin content and the proportion of CS to DS in GAG increased with age. We concluded that the age-related changes in the GAG chain may be related to specific functional properties and may have a crucial role in placental tissue organization. 相似文献
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Batbayar Chingunjav Ishii Norihiro Harimoto Norifumi Yokobori Takehiko Saito Hideyuki Gantumur Dolgormaa Gombodorj Navchaa Erkhem-Ochir Bilguun Muranushi Ryo Hoshino Kouki Yamanaka Takahiro Hagiwara Kei Tsukagoshi Mariko Watanabe Akira Araki Kenichiro Hosouchi Yasuo Shirabe Ken 《International journal of clinical oncology / Japan Society of Clinical Oncology》2023,28(7):901-912
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Ryo Muranushi Kenichiro Araki Takehiko Yokobori Batbayar Chingunjav Kouki Hoshino Gantumur Dolgormaa Kei Hagiwara Takahiro Yamanaka Norihiro Ishii Mariko Tsukagoshi Takamichi Igarashi Akira Watanabe Norio Kubo Norifumi Harimoto Yuki Shimoda Rie Sano Tetsunari Oyama Hiroshi Saeki Ken Shirabe 《Cancer science》2021,112(8):3314-3323
CKLF-like MARVEL transmembrane domain–containing protein 6 (CMTM6) maintains membrane PD-L1 expression by controlling its endosomal recycling. However, in patients with hepatocellular carcinoma (HCC), the correlation among CMTM6, B7 family ligands, and CD8-positive cytotoxic T lymphocytes (CTLs), and the molecular function of CMTM6 in HCC have not been established. We performed immunohistochemistry to evaluate the relationships among CMTM6 expression, clinicopathological factors, B7 family ligands expression, and CTL infiltration in HCC samples. Moreover, we established CMTM6-knockout human HCC cell lines to evaluate the function of human CMTM6 in immune regulation and tumor viability. CMTM6 expression was positively associated with membrane B7 family ligands expression and CTL infiltration in HCC samples. High CMTM6 expression in HCC tissues was associated with the expression of the proliferation marker Ki-67 and shorter recurrence-free survival. In vitro analysis showed the downregulation of membrane B7 family ligands and proliferation potency in the CMTM6-knockout human HCC cell line. High membrane CMTM6 expression was associated with tumor recurrence and proliferation via the regulation of membranous B7 family ligands expression. Thus, CMTM6 might be a biomarker to predict the risk of HCC recurrence and a therapeutic target to suppress tumor growth and increase CTL activity. 相似文献
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Gamma‐aminobutyric acidA receptor agonist,muscimol, increases KiSS‐1 gene expression in hypothalamic cell models
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Haruhiko Kanasaki Tuvshintugs Tumurbaatar Aki Oride Tomomi Hara Hiroe Okada Satoru Kyo 《Reproductive Medicine and Biology》2017,16(4):386-391