山莨菪碱防治甘油所致急性肾功能衰竭的实验研究

在１２９只ＳＤ大鼠的实验中动态观察了山莨菪碱对甘油所致急性肾功能衰竭时不同时期的Ｂｃｒ，ＢＵＮ，ｐＨ病理改变及死亡率的影响，结果表明：山莨菪碱能降低ＡＲＦ第５天大鼠死亡率以及Ｂｃｒ，ＢＵＮ水平。改善病理损害，对ＡＲＦ起到预防及治疗效果，山莨菪碱的预防效果优于治疗效果，预防是ＡＲＦ防治的关键，但山莨菪碱在治疗过程中要引起“冲刷综合征”导致洗脱性酸中毒，应引起注意。     

系统性红斑狼疮肺胸膜病变(附50例报告)

50例SLE患者有肺胸膜病变,其中女性47例(94％),男性3例(6％),小于40岁者41例(82％)。50例中表现为胸膜炎和(或)胸腔积液26例,狼疮肺炎15例,弥漫性肺间质纤维化5例,肺不张3例,肺纹理增多17例。经激素治疗随SLE症状改善,肺胸膜病变好转。     

Effect Of Pulsatile Electromagnetic Fields On Blood Viscosity And Coagulation

Ithasbeenprovedthatanumberofdiseasesarerelatedwithabnormalityofbloodviscosityandcoagulationinclinicalresearch.Bloodhyperviscosityandhypercoagulationcauseandaccelearatethedevelopmentofcertaindiseases,deathrateofsomeofwhicharerisingwithyears.Lookingforawaytoreducebloodviscosityandrestrainfasterandstrongercoagulationbecomesasubjectdrawingmoreattention.Theproperseofthisresearchwastofindsuchaway.Intheblood,therearechargrdRBC,WBC,PLT,inorganicions,sothattheremustbesensitiveandcomplicatedresponse…     

胰岛素对新生大鼠缺氧/复氧心肌细胞凋亡的影响

目的:探讨胰岛素在新生大鼠缺氧/复氧心肌细胞损伤中对细胞凋亡的影响。方法:通过给原代培养乳鼠心室肌细胞行缺氧2 h/复氧4 h,建立缺氧/复氧(Anoxia/Reoxygenation)心肌细胞损伤模型。将培养心肌细胞随机分为:正常对照组(CON)、缺氧/复氧组(A/R)、缺氧/复氧+胰岛素组(I/R+INS)。于复氧4 h后,利用2,4二硝基苯肼显色法检测乳酸脱氢酶(LDH)活性,硫代巴比妥酸显色法检测丙二醛(MDA)含量,原位末端标记法(TINEL)和DNA梯带法(DNA Ladder)检测细胞凋亡,并比较各组间差异。结果:与A/R组相比,A/R+INS可明显降低MDA、LDH值(P<0.01),抑制心肌细胞凋亡(P<0.01)。结论:胰岛素具有减少新生大鼠缺氧/复氧心肌细胞损伤作用,其作用机制与抑制细胞凋亡作用有关。     

Clinical experience with the MLCu250 IUD (eight-year results)

Between 1977 and 1981, 1561 MLCu250 standard model IUDs were inserted at the Family Planning Center, Department of Obstetrics and Gynecology, University Medical School of Debrecen, Hungary. The majority were in the first (61.3%) and second (32.2%) segment and only a few were in the third (5.4%), fourth (1.0%) or fifth (0.1%) segment.Insertions were performed in the postmenstrual, postabortal, postpartal and postpuerperal periods. This report evaluates the data for interval insertions only, representing a total of 1457 cases and 65762 woman-months of use during an 8-year follow-up period. Using Tietze's life table technique, cumulative and yearly specific termination rates have been calculated. Fifty per cent of the devices were in place after 5 years of use, and 27.8% of the patients wore the IUD even at the end of the eighth year after insertion. The pertinent termination rate (pregnancy, expulsion, removal for bleeding/pain and for other medical reasons together) was 56.8 in the 96th ordinal month. These findings prove the good over-all performance of the MLCu250 IUD and demonstrate a longer life span for the device than was previously expected.

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Resumen Entre 1977 y 1981 se colocaron 1561 DIU MLCu250 Modelo estánder en el Centro de Planificación Familiar del Departamento de Obstetricia y Ginecología de la Escuela Medica de la Universidad de Debrecen, Hungria. La mayoría fueron insertados en el primer (61,3%) y segundo grupo (32,2%) y, solamente, unos pocos fueron insertados en el tercer (5,4%), cuarto (1,0%) o quinto grupos. Se efectuaron inserciones en períodos post-menstruales, post-aborto, post-parto y post-puerperal. Este informe evalúa solamente los datos de inserciones de intervalo que representan un total de 1457 casos y 65762 mujeres-ciclos de uso durante ocho años de seguimiento. Usando la técnica de tabla de vida de Tietze, se calcularon las tasas cumulativas anuales específicas de terminación. Cincuenta por ciento de los dispositivos permanecian en su sitio despues de cinco años de uso y 27,8% de las pacientes mantuvieron el DIU hasta el final del octavo año. La tasa pertinente de terminación fue de 56,8 en el 96 mes. Estos resultados indican el buen desempeño general del DIU MLCu250 y señalan un período de vida para el dispositivo más largo que el esperado.

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Resumé Entre 1977 et 1981, le Centre de Planning Familial du Service d'Obstétrique et de Gynécologie de la Faculté de Médecine de l'Université de Debrecen en Hongrie a mis en place 1561 stérilets MLCu250 standards, dont la plupart dans le premier (61,3%) et le second (32,2%) segments, et quelques-uns seulement dans les troisième (5,4%), quatrième (1%) et cinquième (0,1%) segments.Les stérilets ont été mis en place durant les périodes post-menstruelle, post-abortive, post-natale et post-puérpérale. Dans ce rapport, l'auteur a évalué que les résultats relatifs aux intervalles d'utilisation, ce qui correspond au total à 1457 cas et 65762 mois d'utilisation par les femmes concernées, dans le cadre d'une période de suivi de huit ans. Les taux de terminaison d'emploi cumulatifs et annuels spécifiques ont été calculés par la technique des tables de Tietze (tables de survie). Après cinq ans d'emploi, cinquante pour cent des stérilets étaient encore en place et, même à la fin de la huitième année, 27,8% des patientes portaient toujours leur stérilet. Le taux de terminaisons pertinent a été de 56,8 pendant le 96 ème mois ordinal. Ces résultats prouvent que la performance d'ensemble des stérilets MLCu250 est bonne, et démontrent que leur durabilité excède les prévisions.

     

大鼠膈腹膜间皮通透性的电镜观察

腹膜腔内注射兔血液和中墨汁后，用电镜观察了大鼠膈腹膜间皮对示踪剂血细胞和碳颗粒的通透笥。在膈膜隐窝区，示踪剂经三种途径通过膈腹膜间皮。（１）间皮孔的吸收作用。示踪剂由腹膜腔经间皮孔直接进入膈毛细淋巴管，或被成纤维细胞的突起包绕。（２）间皮细胞的吞噬作用。（３）示踪剂通过间皮细胞间裂隙或细胞间连接。     

大鼠膈腹膜间皮孔的电镜观察

用扫描电镜和透射电镜观察了正常大鼠膈腹膜间皮，并观察了腹膜腔内注射中国墨汁和兔血液后大鼠膈腹膜间皮的变化以及腹膜腔和间皮下毛细淋巴管的关系。     

Hairy cell leukemia: authors' own experience (1977-1998)]

Hairy cell leukaemia (HCL) is a rare, clinically and haematologically well characterised entity. The prognosis of patients with hairy cell leukaemia has significantly improved due to the new therapeutic approaches. Development of diagnostic and therapeutic methods, together with the analysis of their own hairy cell leukaemia patients, is reviewed by the authors. Between 1977 and 1998 twenty five patients (16 male, 9 female) were treated. The malignant cells were usually analysed by morphological and cytochemical methods and recently flow cytometric analysis could be performed in eight patients. Splenectomy with lethal outcome in six patients was performed in 21 cases. Approximately one third of patients received interferon, while 2-chlorodeoxyadenosine was given only to three patients. Favourable experiences obtained by splenectomy and efficacy of interferon treatment are emphasised, but according to the literature and their own results administration of purine analogues can be highly recommended in the future.     

电针治疗对老年性痴呆大鼠血清β淀粉样蛋白及生长因子水平的影响

目的:观察电针对老年性痴呆(AD)模型大鼠β-淀粉样蛋白及转化生长因子(TGF-α)的影响,揭示针灸治疗的作用机理和针灸治疗AD的免疫基础。方法:建立AD大鼠模型,随机分为电针组、喜得镇组、模型自然恢复组、假手术组,观察血清β-AP和TGF-α水平。结果:电针组和喜得镇组大鼠血清β-AP水平明显下降(P<0.05),但仍明显高于假手术组。结论:电针能降低AD模型大鼠血清中β淀粉样蛋白及TGF-α。